The Registry of Toxic Effects of Chemical Substances

Methacrylaldehyde

RTECS #: OZ2625000

CAS #: 78-85-3

UPDATE: February 2003 MW: 70.10 MF: C4H6O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Acrolein, 2 - methyl -
  2. Isobutenal
  3. Methacrolein
  4. Methacrylic aldehyde
  5. Methakrylaldehyd (Czech)
  6. alpha - Methylacrolein
  1. 2 - Methylacrolein
  2. Methylacrylaldehyde
  3. 2 - Methylpropenal
  4. NSC 8260
  5. 2 - Propenal, 2 - methyl -


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,271,1986
skin
rabbit 		2 mg/24 hour severe 85JCAE -,271,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage rat liver 7,100 µmol/L MUREAV 419,69,1998
mutation in microorganisms Escherichia coli 300 nmol/plate MUREAV 516,81,2002
mutation in microorganisms Salmonella typhimurium 500 nmol/L (+enzymatic activation step) MUREAV 148,25,1985
mutation in microorganisms Salmonella typhimurium 500 µmol/L (-enzymatic activation step) MUREAV 93,305,1982
mutation in microorganisms Salmonella typhimurium 1 µmol/L/20 minute (-enzymatic activation step) EMMUEG 37,324,2001
mutation in microorganisms Salmonella typhimurium 1.8 µmol/L/20 minute (+enzymatic activation step) EMMUEG 37,324,2001


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 810 mg/m3/2 hour N/R VCVGK* -,389,1984
inhalation
rat 		lowest published lethal concentration: 125 ppm/4 hour N/R JIHTAB 31,343,1949
oral
rat 		lethal dose (50 percent kill): 140 mg/kg N/R UCDS** 7/21/1965
skin
rabbit 		lethal dose (50 percent kill): 430 µL/kg N/R JIHTAB 31,60,1949


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

NIOSH PROFILE (ALDEHYDES), SRC, 4/78

NIOSH PROFILE (ALDEHYDES), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Primary Irritant

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