The Registry of Toxic Effects of Chemical Substances

Methacrylic acid

RTECS #: OZ2975000

CAS #: 79-41-4

UPDATE: November 2004 MW: 86.10 MF: C4H6O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Acrylic acid, 2 - methyl -
  2. Kyselina methakrylova (Czech)
  3. Methacrylic acid (ACGIH)
  4. No Lift Nails Primer
  1. Propionic acid, 2 - methylene -
  2. alpha - Methylacrylic acid
  3. 2 - Methylpropenoic acid
  4. 2 - Propenoic acid, 2 - methyl - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 50 µmol/L MUREAV 89,95,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 48 mg/kg N/R JPMSAE 62,778,1973
intravenous
dog 		lowest published lethal dose: 95,200 nL/kg N/R JPMSAE 63,376,1974
oral
child 		lowest published toxic dose: 250 µL/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Gastrointestinal: Nausea or vomiting

Skin: After systemic exposure: Dermatitis, other 		PEDIAU 102,979,1998
oral
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R GTPZAB 25(11),57,1981
oral
rat 		lethal dose (50 percent kill): 1,060 mg/kg N/R GISAAA 41(4),6,1976
oral
rabbit 		lethal dose (50 percent kill): 1,200 mg/kg N/R GISAAA 38(8),13,1973
skin
guinea pig 		lethal dose (50 percent kill): 1 gm/kg N/R 38MKAJ 2C,4953,1982
skin
rabbit 		lethal dose (50 percent kill): 500 mg/kg N/R 85INA8 5,362,1986
unreported route
mouse 		lethal dose (50 percent kill): 1,250 mg/kg N/R GISAAA 49(10),64,1984
unreported route
rat 		lethal dose (50 percent kill): 1,600 mg/kg N/R GISAAA 49(10),64,1984


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 221 mg/m3/24 hour/17 week- continuous Behavioral: Alteration of classical conditioning GISAAA 46(5),10,1981
inhalation
rat 		lowest published toxic concentration: 221 mg/m3/24 hour/17 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases GISAAA 46(5),10,1981
oral
rat 		lowest published toxic dose: 910 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning GISAAA 38(8),13,1973
oral
rabbit 		lowest published toxic dose: 910 mg/kg/26 week- intermittent Liver: Liver function tests impaired

Nutritional and Gross Metabolic: Changes in: Metabolic acidosis 		GISAAA 38(8),13,1973


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 20 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
EVHPAZ 11,141,1975


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 20 ppm (70 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 20 ppm (70 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 20 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY No MAK Established, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 70 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 101 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWEDEN NGV 20 ppm (70 mg/m3), KTV 30 ppm (100 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 20 ppm (70 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 20 ppm (72 mg/m3), short term exposure limit 40 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 20 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 20 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHACRYLIC ACID-air 10 hour time-weighted average 20 ppm (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M3304;
Number of Industries 12;
Total Number of Facilities 1,529;
Number of Occupations 31;
Total Number of Employees Exposed 18,977
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M3304;
Number of Industries 109;
Total Number of Facilities 10,110;
Number of Occupations 75;
Total Number of Employees Exposed 145,414;
Total Number of Female Employees Exposed 46,453


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of methacrylates and carboxylated polymers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PEDIAU Pediatrics. (American Academy of Pediatrics, P.O. Box 1034, Evanston, IL 60204) V.1- 1948-

Used in preparation of methacrylates and carboxylated polymers

RTECS Compound Description:
   Drug
   Mutagen
   Human Data

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