The Registry of Toxic Effects of Chemical Substances
Methane, bromochlorodifluoro - RTECS #: PA5270000
CAS #: 353-59-3
The Registry of Toxic Effects of Chemical Substances
Methane, bromochlorodifluoro - |
| UPDATE: February 2004 | MW: 165.37 | MF: CBrClF2 |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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mutation in microorganisms
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Salmonella typhimurium
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10 pph (+enzymatic activation step)
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MUREAV 142,187,1985
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 50,000 ppm (6-15 day pregnant)
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Reproductive: Other effects on female
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BJIMAG 45,755,1988
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | dog
lowest published lethal concentration: 5 pph/30 minute
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Cardiac: Other changes
NTIS** OTS0571363
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inhalation | guinea pig
lowest published lethal concentration: 30 pph/2 hour
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Behavioral: Convulsions or effect on seizure threshold
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ZAARAM 21,149,1971
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inhalation | human
lowest published toxic concentration: 295,200 mg/m3/1 minute
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Peripheral Nerve and Sensation: Paresthesia
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VCVGH* -,631,1990
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inhalation | man
lowest published toxic concentration: 4 pph/1 minute
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Peripheral Nerve and Sensation: Paresthesia | Behavioral: Hallucinations, distorted perceptions Cardiac: EKG changes not diagnostic of above
NTIS** OTS0571363
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inhalation | rat
lethal concentration (50 percent kill): 20 pph/15 minute
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Behavioral: Tremor | Behavioral: Convulsions or effect on seizure threshold Lung, Thorax, or Respiration: Respiratory depression
HUTODJ 1,239,1982
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inhalation | rat
lethal concentration (50 percent kill): 2,140,000 mg/m3/5 minute
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N/R
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VCVGH* -,631,1990
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inhalation | rat
lowest published toxic concentration: 396,000 mg/m3/10 minute
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Behavioral: General anesthetic
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VCVGH* -,631,1990
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | rat
lowest published toxic concentration: 210 µg/m3/4 hour/12 week- intermittent
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Blood: Pigmented or nucleated red blood cells | Blood: Changes in erythrocyte (RBC) count Blood: Changes in platelet count
BCTKAG 17,41,1984
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inhalation | rat
lowest published toxic concentration: 1 pph/6 hour/3 week- intermittent
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Behavioral: Somnolence (general depressed activity)
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NTIS** OTS0571363
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Occupational Exposure Limit - RUSSIA
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short term exposure limit 1000 mg/m3, JAN1993
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used in fire extinguishers
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EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9154
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
BCTKAG
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Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4-
1971-
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BJIMAG
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British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME
04046) V.1- 1944-
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HUTODJ
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Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1-
1981-
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NTIS**
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National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse
for Scientific & Technical Information.
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VCVGH*
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"Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances:
Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
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ZAARAM
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Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25,
1951-75.
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