The Registry of Toxic Effects of Chemical Substances

Methane, chlorodifluoro -

RTECS #: PA6390000

CAS #: 75-45-6

UPDATE: November 2004 MW: 86.47 MF: CHClF2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Algeon 22
  2. Algofrene 22
  3. Algofrene type 6
  4. Arcton 4
  5. Arcton 22
  6. CFC 22
  7. Chlorodifluoromethane (ACGIH)
  8. Daiflon 22
  9. Difluorochloromethane
  10. Difluoromonochloromethane
  11. Dymel 22
  12. Electro - CF 22
  13. Eskimon 22
  14. F 22
  15. Flugene 22
  16. Fluorocarbon - 22
  1. Forane 22
  2. Freon 22
  3. Frigen 22
  4. Genetron 22
  5. Haltron 22
  6. HFA - 22
  7. Isceon 22
  8. Isotron 22
  9. Khaladon 22
  10. R - 22
  11. Racon 22
  12. Monochlorodifluoromethane
  13. Propellant 22
  14. Refrigerant R 22
  15. R 22 (refrigerant)
  16. Ucon 22


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 33 pph/24 hour- continuous (+/-enzymatic activation step) TOLED5 2,1,1978


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 50,000 ppm/5 hour (56 day male) Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands FAATDF 1,266,1981
inhalation
rat 		lowest published toxic concentration: 5 ppm (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear NTIS** OTS0520838
inhalation
rat 		lowest published toxic dose: 50,000 ppm/6 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear NTIS** OTS0545682


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 70 pph Lung, Thorax, or Respiration: Other changes TXAPA9 2,363,1960
inhalation
guinea pig 		lowest published lethal concentration: 30 pph/2 hour Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		ZAARAM 21,149,1971
inhalation
guinea pig 		lowest published toxic concentration: 584,000 mg/m3/55 minute Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		VCVGH* -,618,1990
inhalation
guinea pig 		lowest published toxic concentration: 1,380,000 mg/m3/2 hour Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		VCVGH* -,618,1990
inhalation
guinea pig 		lowest published lethal concentration: 1,800,000 mg/m3/18 minute N/R VCVGH* -,618,1990
inhalation
mouse 		lethal concentration (50 percent kill): 1,380 gm/m3/2 hour Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Cyanosis 		TLSMA6 75,241,1963
inhalation
mouse 		lethal concentration (50 percent kill): 1,000,000 mg/m3/2 hour N/R VCVGH* -,618,1990
inhalation
mouse 		lethal concentration (50 percent kill): 1,020,000 mg/m3/30 minute N/R VCVGH* -,618,1990
inhalation
rat 		lethal concentration (50 percent kill): 35 pph/15 minute Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory depression 		HUTODJ 1,239,1982
inhalation
rabbit 		lowest published lethal concentration: 1,100,000 mg/m3/30 minute N/R VCVGH* -,618,1990
inhalation
rabbit 		lowest published lethal concentration: 1,530,000 mg/m3/20 minute N/R VCVGH* -,618,1990
oral
rat 		lethal dose : >43,200 µg/kg N/R GISAAA 48(8),69,1983


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 50 gm/m3/6 hour/43 week- intermittent Brain and Coverings: Other degenerative changes

Spinal Cord: Other degenerative changes

Behavioral: Alteration of classical conditioning 		TLSMA6 75,231,1963
oral
rat 		lowest published toxic dose: 2,457 mg/kg/26 week- intermittent Brain and Coverings: Other degenerative changes

Blood: Changes in other cell count (unspecified)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GISAAA 48(8),69,1983


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,237,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,237,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,1339,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1339,1999
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
NYSJAM 74,1939,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 500 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (3540 mg/m3), short term exposure limit 1250 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 500 ppm (1770 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (3500 mg/m3), short term exposure limit 1250 ppm, JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (3500 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 500 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 3600 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 500 ppm (1750 mg/m3), JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 1000 ppm, short term exposure limit 3000 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 500 ppm (1800 mg/m3), KTV 750 ppm (2500 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 500 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (3590 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO CHLORODIFLUOROMETHANE-air time-weighted average 1000 ppm;
short term exposure limit 1250 ppm 		NIOSH* DHHS #95-121,1995
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80048;
Number of Industries 76;
Total Number of Facilities 7,420;
Number of Occupations 44;
Total Number of Employees Exposed 56,234
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80048;
Number of Industries 78;
Total Number of Facilities 12,513;
Number of Occupations 57;
Total Number of Employees Exposed 157,080;
Total Number of Female Employees Exposed 12,185


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in refrigeration and air conditioning
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9099;8EHQ-0892-9107
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9108;8EHQ-0892-9117
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9118
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Chlorodifluoromethane, 1018


REFERENCES:

CODEN
REFERENCE
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZAARAM Zentralblatt fuer Arbeitsmedizin und Arbeitsschutz. (Darmstadt, Fed. Rep. Ger.) V.1-25, 1951-75.

Used in refrigeration and air conditioning

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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