The Registry of Toxic Effects of Chemical Substances

Methane, dibromo -

RTECS #: PA7350000

CAS #: 74-95-3

UPDATE: February 2004 MW: 173.85 MF: CH2Br2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Methylene bromide
  2. Methylene dibromide
  1. RCRA waste number U068


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 µmol/L TECSDY 13,205,1987
mutation in microorganisms Salmonella typhimurium 100 ng/plate (+enzymatic activation step) BECTA6 24,590,1980
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) TECSDY 13,205,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 40 gm/m3/2 hour N/R 85GMAT -,83,1982
inhalation
rat 		lowest published toxic concentration: 1,000 mg/m3/2 hour Brain and Coverings: Changes in surface EEG VCVGH* -,579,1990
inhalation
rat 		lethal concentration (50 percent kill): 40,000 mg/m3 N/R VCVGH* -,579,1990
oral
rat 		lethal dose (50 percent kill): 108 mg/kg N/R NTIS** PB85-143766
oral
rabbit 		lethal dose (50 percent kill): 1 gm/kg N/R DOWCC* MSD-472
rectal
rabbit 		lowest published lethal dose: 5 gm/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation

Gastrointestinal: Changes in structure or function of salivary glands 		JPETAB 34,223,1928
subcutaneous
mouse 		lethal dose (50 percent kill): 3,738 mg/kg N/R TXAPA9 4,354,1962
skin
rabbit 		lethal dose (50 percent kill): >4 gm/kg N/R DOWCC* MSD-472


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
human 		lowest published toxic concentration: 40 mg/m3/2 year- intermittent Behavioral: Anorexia (human)

Behavioral: Headache

Lung, Thorax, or Respiration: Dyspnea 		VCVGH* -,579,1990
oral
rat 		lowest published toxic dose: 333 mg/kg/28 day- continuous Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		BECTA6 41,515,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4051;
Number of Industries 2;
Total Number of Facilities 33;
Number of Occupations 2;
Total Number of Employees Exposed 1,065;
Total Number of Female Employees Exposed 452


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
DOWCC* Dow Chemical Company Reports. (Dow Chemical USA, Health and Environment Research, Toxicology Research Lab., Midland, MI 48640)
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TECSDY Toxicological and Environmental Chemistry. (Gordon & Breach Science Pub. Inc., 1 Park Ave., New York, NY 10016) V.3(3/4)- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

NIOSH PROFILE (ALIPHATICS, BROMINATED), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data

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