The Registry of Toxic Effects of Chemical Substances

Methane, dichloro -

RTECS #: PA8050000

CAS #: 75-09-2

UPDATE: May 2005 MW: 84.93 MF: CH2Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Aerothene MM
  2. Chlorure de methylene (French)
  3. Dichloromethane
  4. Dichloromethane (DOT:OSHA)
  5. F 30 (chlorocarbon)
  6. Freon 30
  7. HCC 30
  8. Khladon 30
  9. Methane dichloride
  10. Methylene bichloride
  11. Methylene chloride
  1. Methylene chloride (ACGIH:OSHA)
  2. Methylene dichloride
  3. Metylenu chlorek (Polish)
  4. NCI - C50102
  5. Narkotil
  6. R 30
  7. R30 (refrigerant)
  8. RCRA waste number U080
  9. Solaesthin
  10. Soleana VDA
  11. Solmethine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		162 mg moderate EJTXAZ 9,171,1976
eye
rabbit 		10 mg mild TXCYAC 6,173,1976
eye
rabbit 		500 mg/24 hour mild 85JCAE -,88,1986
skin
rabbit 		810 mg/24 hour severe EJTXAZ 9,171,1976
skin
rabbit 		100 mg/24 hour moderate 85JCAE -,88,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1 µmol/L TECSDY 13,205,1987
cytogenetic analysis hamster ovary 6,628 mg/L MUREAV 116,361,1983
cytogenetic analysis inhalation
mouse 		27,760 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
DNA damage hamster ovary 3,000 ppm MUREAV 367,143,1996
DNA damage human lung 1,000 µmol/L/3 hour MUREAV 538,41,2003
DNA damage mouse liver 400 µmol/L CRNGDP 15,991,1994
DNA damage inhalation
mouse 		4,000 ppm/6 hour- continuous CRNGDP 15,991,1994
DNA damage oral
mouse 		1,720 mg/kg MUREAV 419,13,1998
DNA damage oral
rat 		1,275 mg/kg TCMUD8 9,61,1989
DNA damage rat liver 30 µmol/L CRNGDP 15,991,1994
DNA inhibition hamster lung 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
DNA inhibition human fibroblast 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
mutation in microorganisms Escherichia coli 6,300 ppm (+/-enzymatic activation step) EMMUEG 20,211,1992
mutation in microorganisms Salmonella typhimurium 5,700 ppm (+/-enzymatic activation step) MUREAV 56,245,1978
micronucleus test inhalation
mouse 		27,760 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
mutation in mammalian somatic cells hamster ovary 3,000 ppm MUREAV 367,143,1996
morphological transform hamster embryo 1,300 µL/plate EVSRBT 25,75,1982
morphological transform mouse fibroblast 0.1 mg/L/21 day (-enzymatic activation step) EMMUEG 35,300,2000
morphological transform rat embryo 160 µmol/L ITCSAF 14,290,1978
other mutation test systems hamster ovary 6,628 mg/L MUREAV 116,361,1983
phage inhibition capacity Escherichia coli 8,250 µg/well MUREAV 260,349,1991
sister chromatid exchange hamster lung 5,000 ppm/1 hour- continuous MUREAV 81,203,1981
sister chromatid exchange inhalation
mouse 		13,880 mg/m3/6 hour/2 week- intermittent EMMUEG 15,221,1990
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		125 mmol/L MUREAV 90,91,1981
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 32,84,1975
inhalation
rat 		lowest published toxic concentration: 4,500 ppm/24 hour (1-17 day pregnant) Reproductive: Effects on newborn: Behavioral TXAPA9 52,29,1980
inhalation
rat 		lowest published toxic concentration: 1,250 ppm/7 hour (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		TXAPA9 32,84,1975


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 2,000 ppm/5 hour/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTPTR* NTP-TR-306,1986
inhalation
mouse 		lowest published toxic concentration: 122,400 mg/kg/102 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB86-187903/AS
inhalation
rat 		lowest published toxic concentration: 3,500 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		FAATDF 4,30,1984
inhalation
rat 		lowest published toxic concentration: 122,400 mg/kg/103 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** PB86-187903/AS
inhalation
rat 		lowest published toxic concentration: 102,000 mg/kg/102 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Skin and Appendages: Tumors

Blood: Leukemia 		NTIS** PB86-187903/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		lowest published toxic dose: 0.25 mL/kg Eye: Increased intraocular pressure

Eye: Conjunctiva irritation

Eye: Corneal damage 		VCVGH* -,323,1990
inhalation
cat 		lowest published lethal concentration: 43,400 mg/m3/4.5 hour Behavioral: General anesthetic

Behavioral: Ataxia

Nutritional and Gross Metabolic: Body temperature decrease 		AHBAAM 116,131,1936
inhalation
dog 		lowest published lethal concentration: 14,108 ppm/7 hour Eye: Miosis (pupilliary constriction)

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea 		NIHBAZ 191,1,1949
inhalation
guinea pig 		lowest published lethal concentration: 5,000 ppm/2 hour N/R FLCRAP 1,197,1967
inhalation
guinea pig 		lethal concentration (50 percent kill): 40,200 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
guinea pig 		lowest published toxic concentration: 21,000 mg/m3/45 minute Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
human 		lowest published toxic concentration: 500 ppm/1 year- intermittent Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Cardiac: Change in rate 		ABHYAE 43,1123,1968
inhalation
human 		lowest published toxic concentration: 500 ppm/8 hour Behavioral: Euphoria SCIEAS 176,295,1972
inhalation
human 		lowest published toxic concentration: 69,600 mg/m3/30 minute Behavioral: General anesthetic VCVGH* -,321,1990
inhalation
human 		lowest published toxic concentration: 25,000 mg/m3/8 minute Peripheral Nerve and Sensation: Paresthesia

Eye: Conjunctiva irritation 		VCVGH* -,321,1990
inhalation
human 		lowest published toxic concentration: 8,000 mg/m3/30 minute Gastrointestinal: Nausea or vomiting VCVGH* -,321,1990
inhalation
mouse 		lethal concentration (50 percent kill): 14,400 ppm/7 hour N/R NIHBAZ 191,1,1949
inhalation
mouse 		lowest published toxic concentration: 32,500 mg/m3/2 hour Behavioral: General anesthetic VCVGH* -,307,1990
inhalation
mouse 		lethal concentration (50 percent kill): 49,100 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
mouse 		lethal concentration (16 percent kill): 53,000 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
mouse 		lethal concentration (50 percent kill): 54,000 mg/m3/2 hour N/R VCVGH* -,320,1990
inhalation
mouse 		lethal concentration (84 percent kill): 75,000 mg/m3/2 hour N/R VCVGH* -,320,1990
inhalation
mouse 		lethal concentration (50 percent kill): 56,220 mg/m3/7 hour N/R VCVGH* -,320,1990
inhalation
mouse 		lowest published toxic concentration: 40,000 mg/m3 Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
mouse 		lowest published toxic concentration: 17,000 mg/m3/2 hour Behavioral: Somnolence (general depressed activity) VCVGH* -,320,1990
inhalation
rat 		lethal concentration (50 percent kill): 52 gm/m3 N/R TPKVAL 15,64,1979
inhalation
rat 		lethal concentration (50 percent kill): 76,000 mg/m3/4 hour N/R VCVGH* -,320,1990
inhalation
rat 		lethal concentration (50 percent kill): 52,000 mg/m3/6 hour N/R VCVGH* -,320,1990
inhalation
rat 		lowest published toxic concentration: 50,000 mg/m3 Behavioral: General anesthetic VCVGH* -,320,1990
inhalation
rat 		lowest published toxic concentration: 1,000 mg/m3/30 minute Endocrine: Adrenal cortex hyperplasia

Behavioral: Alteration of classical conditioning 		VCVGH* -,320,1990
inhalation
rabbit 		lowest published lethal concentration: 10,000 ppm/7 hour N/R JIHTAB 26,8,1944
intraperitoneal
dog 		lethal dose (50 percent kill): 1,274 mg/kg N/R TXAPA9 10,119,1967
intraperitoneal
mouse 		lethal dose (50 percent kill): 437 mg/kg N/R AGGHAR 18,109,1960
intraperitoneal
rat 		lethal dose (50 percent kill): 916 mg/kg N/R ENVRAL 40,411,1986
intraperitoneal
rat 		lowest published toxic dose: 510 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia VCVGH* -,320,1990
intratracheal
rat 		lowest published lethal dose: 350 mg/kg Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Acute pulmonary edema 		NTIS** OTS0520615
intravenous
dog 		lowest published lethal dose: 200 mg/kg N/R QJPPAL 7,205,1934
intravenous
mouse 		lowest published toxic dose: 133 mg/kg Kidney, Ureter, and Bladder: Other changes VCVGH* -,320,1990
intravenous
rat 		lowest published toxic dose: 1,000 mg/kg Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		VCVGH* -,320,1990
oral
dog 		lowest published lethal dose: 3 gm/kg N/R QJPPAL 7,205,1934
oral
dog 		lethal dose (50 percent kill): 3,000 mg/kg N/R VCVGH* -,320,1990
oral
human 		lowest published lethal dose: 357 mg/kg Peripheral Nerve and Sensation: Paresthesia

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		34ZIAG -,390,1969
oral
man 		lowest published toxic dose: 1,429 µL/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Changes in: Fe 		YAKUD5 36,575,1994
oral
mouse 		lethal dose (50 percent kill): 873 mg/kg N/R EVHPAZ 106(Suppl 2),497,1998
oral
mouse 		lethal dose (16 percent kill): 620 mg/kg N/R VCVGH* -,320,1990
oral
mouse 		lethal dose (84 percent kill): 1,650 mg/kg N/R VCVGH* -,320,1990
oral
rat 		lethal dose (50 percent kill): 1,600 mg/kg Behavioral: Ataxia FAONAU 48A,94,1970
oral
rat 		lethal dose (50 percent kill): 985 mg/kg N/R VCVGH* -,320,1990
oral
rat 		lethal dose (16 percent kill): 800 mg/kg N/R VCVGH* -,320,1990
oral
rat 		lethal dose (84 percent kill): 2,200 mg/kg N/R VCVGH* -,320,1990
oral
rat 		lowest published toxic dose: 237.8 mg/kg Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) VCVGH* -,321,1990
oral
rabbit 		lowest published lethal dose: 1,900 mg/kg N/R HBTXAC 1,94,1955
oral
rabbit 		lethal dose (50 percent kill): 2,000 mg/kg N/R VCVGH* -,320,1990
subcutaneous
mouse 		lethal dose (50 percent kill): 6,460 mg/kg N/R TXAPA9 4,354,1962
subcutaneous
rabbit 		lowest published lethal dose: 2,700 mg/kg N/R QJPPAL 7,205,1934
unreported route
mouse 		lethal dose (50 percent kill): 4,770 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from small intestine 		ESKGA2 28,P31,1982
unreported route
rat 		lethal dose (50 percent kill): 5,350 mg/kg N/R GISAAA 53(6),78,1988
unreported route
rabbit 		lethal dose (50 percent kill): 1,225 mg/kg N/R GISAAA 53(6),78,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 1,000 ppm/24 hour/7 week- continuous Behavioral: Food intake (animal)

Musculoskeletal: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** AD746-295
inhalation
dog 		lowest published toxic concentration: 5,000 ppm/6 hour/12 week- intermittent Behavioral: Hallucinations, distorted perceptions

Behavioral: Ataxia

Behavioral: Antipsychotic 		NTIS** OTS0555748
inhalation
guinea pig 		lowest published toxic concentration: 552 ppm/6 hour/5 day- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		AIHAAP 37,345,1976
inhalation
monkey 		lowest published toxic concentration: 5,000 ppm/24 hour/32 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTIS** AD746-295
inhalation
mouse 		lowest published toxic concentration: 13,000 ppm/6 hour/19 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-306,1986
inhalation
mouse 		lowest published toxic concentration: 150 ppm/24 hour/30 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		APTOA6 59,73,1986
inhalation
mouse 		lowest published toxic concentration: 5,000 ppm/24 hour/7 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 23,660,1972
inhalation
mouse 		lowest published toxic concentration: 300 ppm/24 hour/90 day- continuous Liver: Changes in liver weight

Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		APTOA6 59,73,1986
inhalation
rat 		lowest published toxic concentration: 3,700 ppm/5 hour/4 week- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		TOLED5 7,41,1980
inhalation
rat 		lowest published toxic concentration: 5,000 ppm/24 hour/14 week- continuous Liver: Other changes

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTIS** AD746-295
inhalation
rat 		lowest published toxic concentration: 8,400 ppm/6 hour/13 week- intermittent Liver: Changes in liver weight

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		NTPTR* NTP-TR-306,1986
inhalation
rat 		lowest published toxic concentration: 500 ppm/6 hour/2 week- intermittent Kidney, Ureter, and Bladder: Other changes

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		RCOCB8 32,535,1981
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/2 hour/3 week- intermittent Behavioral: Food intake (animal)

Liver: Other changes

Blood: Other changes 		HOCHE8 8,64,1990
inhalation
rat 		lowest published toxic concentration: 1,000 ppm/6 hour/3 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Neurotransmitters or modulators (putative): Dopamine at other sites 		TXCYAC 29,293,1984
oral
mouse 		lowest published toxic dose: 1,862 mg/kg/2 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) DCTODJ 6,563,1983
oral
mouse 		lowest published toxic dose: 52,740 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		FCTOD7 24,943,1986
oral
rat 		lowest published toxic dose: 14,940 mg/kg/90 day- continuous Liver: Hepatitis (hepatocellular necrosis), zonal

Liver: Fatty liver degeneration 		FCTOD7 24,943,1986
oral
rat 		lowest published toxic dose: 91 gm/kg/2 year- continuous Behavioral: Fluid intake

Liver: Fatty liver degeneration

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 24,951,1986
skin
rat 		lowest published toxic dose: 39,270 mg/kg/17 week- intermittent Liver: Other changes

Liver: Changes in liver weight 		GTPZAB 26(5),41,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 41,43,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 71,251,1999
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 41,43,1986
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 71,251,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 71,251,1999
TOXICOLOGY REVIEW
TOLED5 127,135,2002
TOXICOLOGY REVIEW
TOLED5 138,9,2003
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003
TOXICOLOGY REVIEW
MUREAV 567,227,2004
TOXICOLOGY REVIEW
MUREAV 567,109,2004
TOXICOLOGY REVIEW
MUREAV 567,151,2004


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,263,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 500 ppm (1750 mg/m3) DTLVS* 3,171,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 500 ppm;
ceiling concentration 1000 ppm;
peak concentration 2000 ppm/5 minute/2 hour 		CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) see 56 FR 57036 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 500 ppm (1740 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 500 ppm (1740 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (350 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (360 mg/m3), Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (174 mg/m3), Carcinogen, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 35 ppm (122 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (350 mg/m3), short term exposure limit 250 ppm (870 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (180 mg/m3), VLE 100 ppm, continuous3 Carcinogen, JAN1999
Occupational Exposure Limit - GERMANY MAK 100 ppm (360 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 10 mg/m3, Carcinogen, JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 350 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 35 ppm (125 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 500 ppm (1740 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 20 mg/m3, short term exposure limit 50 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, short term exposure limit 50 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 35 ppm (120 mg/m3), KTV 70 ppm (250 mg/m3), Skin JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (360 mg/m3), KZG- week 500 ppm (1800 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 500 mg/m3, short term exposure limit 1000 mg/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 500 ppm (1740 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINgDOM time-weighted average 100 ppm (350 mg/m3), short term exposure limit 300 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYLENE CHLORIDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 47270;
Number of Industries 374;
Total Number of Facilities 89,025;
Number of Occupations 192;
Total Number of Employees Exposed 975,696
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 47270;
Number of Industries 363;
Total Number of Facilities 87,086;
Number of Occupations 212;
Total Number of Employees Exposed 1,438,196;
Total Number of Female Employees Exposed 352,536


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2000/108026)
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion; S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as a paint remover, degreaser, solvent and in aerosol propellants
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 46, 1986
NIOSH Analytical Method, 1994: Methylene chloride, 1005
NIOSH Analytical Method, 1996: Volatile organic compound, 2549
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen
OSHA ANALYTICAL METHOD #80


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABHYAE Abstracts on Hygiene. (Bureau of Hygiene and Tropical Diseases, Keppel St., London WC1E 7HT, UK) V.1- 1926-
AGGHAR Archiv fuer Gewerbepathologie und Gewerbehygiene. (Berlin, Ger.) V.1-18, 1930-61. For publisher information, see IAEHDW.
AHBAAM Archiv fuer Hygiene und Bakteriologie. (Munich, Fed. Rep. Ger.) V.101-154, 1929-71. For publisher information, see ZHPMAT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
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Used as a paint remover, degreaser, solvent and in aerosol propellants

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), FIRL, 4/78

NIOSH PROFILE (PAINT AND ALLIED PRODUCTS MANUFACTURING), SRI, 2/7

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Drug
   Mutagen
   Reproductive Effector
   Human Data
   Primary Irritant

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