The Registry of Toxic Effects of Chemical Substances

Methane, dichlorodifluoro -

RTECS #: PA8200000

CAS #: 75-71-8

UPDATE: November 2004 MW: 120.91 MF: CCl2F2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Algofrene type 2
  2. Arcton 12
  3. Arcton 6
  4. CFC 12
  5. Chlorofluorocarbon 12
  6. Dichlorodifluoromethane
  7. Dichlorodifluoromethane (ACGIH:OSHA)
  8. Difluorodichloromethane
  9. Dwuchlorodwufluorometan (Polish)
  10. Dymel 12
  11. Electro - CF 12
  12. Eskimon 12
  13. F 12
  14. FC 12
  15. FCC 12
  16. FKW 12
  1. Fluorocarbon - 12
  2. Forane 12
  3. Freon 12
  4. Freon F - 12
  5. Frigen 12
  6. Genetron 12
  7. Isceon 122
  8. Isotron 12
  9. Kaiser chemicals 12
  10. Ledon 12
  11. Propellant 12
  12. R 12 (refrigerant)
  13. RCRA waste number U075
  14. Refrigerant R 12
  15. Ucon 12
  16. Ucon 12/halocarbon 12


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published toxic concentration: 37 pph/4 minute Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: EKG changes not diagnostic of above 		TXAPA9 29,242,1974
inhalation
dog 		lowest published lethal concentration: 4,845,000 mg/m3/10 minute N/R VCVGH* -,621,1990
inhalation
guinea pig 		lethal concentration (50 percent kill): 80 pph/30 minute N/R EJTXAZ 9,385,1976
inhalation
guinea pig 		lowest published toxic concentration: 106,000 mg/m3/2 hour Lung, Thorax, or Respiration: Cough VCVGH* -,621,1990
inhalation
guinea pig 		lowest published toxic concentration: 1,430,000 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea 		VCVGH* -,621,1990
inhalation
human 		lowest published toxic concentration: 200,000 ppm/30 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Fibrosing alveolitis

Liver: Other changes 		EJTXAZ 9,385,1976
inhalation
human 		lowest published toxic concentration: 431 mg/m3 Brain and Coverings: Changes in surface EEG VCVGH* -,621,1990
inhalation
human 		lowest published toxic concentration: 49,100 mg/m3/150 minute Behavioral: Somnolence (general depressed activity) VCVGH* -,621,1990
inhalation
human 		lowest published toxic concentration: 255,000 mg/m3/5 minute Cardiac: Arrythmias (indlucing changes in conduction) VCVGH* -,621,1990
inhalation
human 		lowest published toxic concentration: 561,000 mg/m3/10 minute Cardiac: Arrythmias (indlucing changes in conduction) VCVGH* -,621,1990
inhalation
mouse 		lethal concentration (50 percent kill): 3,348 gm/m3/3 hour Behavioral: Sleep

Behavioral: Tremor

Behavioral: Excitement 		GISAAA 28(6),95,1963
inhalation
mouse 		lowest published toxic concentration: 100 pph/10 minute Cardiac: EKG changes not diagnostic of above

Cardiac: Pulse rate decreased with fall in BP 		JAMAAP 214,81,1970
inhalation
mouse 		lowest published toxic concentration: 94,500 mg/m3/24 hour Lung, Thorax, or Respiration: Cough VCVGH* -,621,1990
inhalation
mouse 		lowest published toxic concentration: 324,000 mg/m3/10 minute Behavioral: Excitement VCVGH* -,621,1990
inhalation
mouse 		lowest published toxic concentration: 510,000 mg/m3/3 hour Behavioral: Alteration of classical conditioning VCVGH* -,621,1990
inhalation
mouse 		lowest published toxic concentration: 2,160,000 mg/m3/1 minute Behavioral: General anesthetic

Behavioral: Tremor

Behavioral: Excitement 		VCVGH* -,621,1990
inhalation
mouse 		lowest published lethal concentration: 3,294,000 mg/m3/2 hour N/R VCVGH* -,621,1990
inhalation
mouse 		lethal concentration (16 percent kill): 3,650,000 mg/m3/2 hour N/R VCVGH* -,621,1990
inhalation
mouse 		lethal concentration (50 percent kill): 3,168,000 mg/m3/2 hour N/R VCVGH* -,621,1990
inhalation
rat 		lethal concentration : >80 pph/4 hour N/R NTIS** OTS0520424
inhalation
rabbit 		lethal concentration (50 percent kill): 80 pph/30 minute N/R EJTXAZ 9,385,1976
inhalation
rabbit 		lowest published toxic concentration: 255,000 mg/m3/2 minute Cardiac: Cardiac output

Vascular: BP lowering not characterized in autonomic section 		VCVGH* -,621,1990
oral
rat 		lethal dose : >5,600 µg/kg N/R GISAAA 52(3),73,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 3,997 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Hepatitis (hepatocellular necrosis), diffuse

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 10,270,1967
inhalation
monkey 		lowest published toxic concentration: 3,997 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion TXAPA9 10,270,1967
inhalation
rat 		lowest published toxic concentration: 4,136 mg/m3/8 hour/6 week- intermittent Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 10,270,1967
inhalation
rat 		lowest published toxic concentration: 3,997 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 10,270,1967
inhalation
rabbit 		lowest published toxic concentration: 3,997 mg/m3/90 day- continuous Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion TXAPA9 10,270,1967
oral
rat 		lowest published toxic dose: 2,548 mg/kg/26 week- intermittent Behavioral: Alteration of classical conditioning

Blood: Changes in erythrocyte (RBC) count

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 52(3),73,1987


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 1000 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
FAZMAE 18,365,1974
TOXICOLOGY REVIEW
NYSJAM 74,1939,1974


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,312,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1000 ppm (4950 mg/m3) DTLVS* 3,78,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1000 ppm (4950 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1000 ppm (4950 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1000 ppm (4950 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1000 ppm (4950 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 1000 ppm (5000 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 1000 ppm (4950 mg/m3), short term exposure limit 1250 ppm (6200 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1000 ppm (4950 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 1000 ppm (5000 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 100 mg/m3, short term exposure limit 200 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 500 ppm (2500 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5040 mg/m3, 2003
Occupational Exposure Limit - NORWAY time-weighted average 500 ppm (2475 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 4000 mg/m3, MAC(short term exposure limit) 6200 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 500 ppm, short term exposure limit 3000 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 1000 ppm (5000 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1000 ppm (4950 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 1000 ppm (5030 mg/m3), short term exposure limit 1250 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DICHLORODIFLUOROMETHANE-air 10 hour time-weighted average 1000 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 24095;
Number of Industries 403;
Total Number of Facilities 139,220;
Number of Occupations 213;
Total Number of Employees Exposed 1,892,483
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 24095;
Number of Industries 177;
Total Number of Facilities 30,739;
Number of Occupations 140;
Total Number of Employees Exposed 510,790;
Total Number of Female Employees Exposed 143,439


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dichlorodifluoromethane, 1018


REFERENCES:

CODEN
REFERENCE
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EJTXAZ European Journal of Toxicology and Environmental Hygiene. (Paris, France) V.7-9, 1974-76. For publisher information, see TOERD9.
FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JAMAAP JAMA, Journal of the American Medical Association. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1883-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NYSJAM New York State Journal of Medicine. (Medical Soc. of the State of New York, POB 5405, Lake Success, NY 11042) V.1- 1901-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.

RTECS Compound Description:
   Human Data
   Hormone

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