The Registry of Toxic Effects of Chemical Substances

Methane, iodo -

RTECS #: PA9450000

CAS #: 74-88-4

UPDATE: November 2004 MW: 141.94 MF: CH3I


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Halon 10001
  2. Iodometano (Italian)
  3. Iodomethane
  4. Iodure de methyle (French)
  5. Jod - methan (German)
  6. Joodmethaan (Dutch)
  7. Methyl iodide
  1. Methyl iodide (ACGIH:OSHA)
  2. Methyljodid (German)
  3. Methyljodide (Dutch)
  4. Metylu jodek (Polish)
  5. Monoioduro di metile (Italian)
  6. RCRA waste number U138


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe NTIS** OTS0570629
skin
human 		1 gm/10 minute mild BJIMAG 7,122,1950
skin
rat 		1 gm/30 minute mild BJIMAG 7,122,1950
skin
rabbit 		500 mg severe NTIS** OTS0570629


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
DNA repair Escherichia coli 10 µg/disc JJIND8 62,873,1979
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms mouse lymphocyte 50 mg/L/4 hour (+enzymatic activation step) MUREAV 59,61,1979
mutation in microorganisms Salmonella typhimurium 2 µL/plate (+/-enzymatic activation step) JJIND8 62,873,1979
gene conversion and mitotic recombination Saccharomyes cerevisiae 1,000 ppm JJIND8 62,901,1979
mutation in mammalian somatic cells hamster ovary 2 mg/L MUREAV 136,137,1984
mutation in mammalian somatic cells mouse lymphocyte 3,600 µg/L ENMUDM 7,523,1985
morphological transform hamster embryo 1 mg/L IJCNAW 19,642,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 44 mg/kg/8 week- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		CNREA8 35,1411,1975
subcutaneous
rat 		lowest published toxic dose: 50 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Colon tumors

Tumorigenic: Tumors at site of application 		ZEKBAI 74,241,1970


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 5 gm/m3/57 minute- continuous N/R BJIMAG 7,122,1950
inhalation
mouse 		lethal concentration (50 percent kill): 5,000 mg/m3/57 minute N/R VCVGH* -,603,1990
inhalation
rat 		lethal concentration (50 percent kill): 1,300 mg/m3/4 hour N/R VCVGH* -,603,1990
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 51 mg/kg N/R 85GMAT -,84,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 172 mg/kg N/R 85GMAT -,84,1982
intraperitoneal
rat 		lethal dose (50 percent kill): 101 mg/kg N/R 85GMAT -,84,1982
oral
rat 		lethal dose (50 percent kill): 76 mg/kg N/R BIJOAK 98,38,1966
oral
rabbit 		lowest published lethal dose: 70 mg/kg N/R 38MKAJ 2B,3447,1981
subcutaneous
mouse 		lethal dose (50 percent kill): 110 mg/kg N/R TXAPA9 4,354,1962
subcutaneous
rat 		lethal dose (50 percent kill): 110 mg/kg N/R ZEKBAI 74,241,1970
skin
guinea pig 		lethal dose (50 percent kill): 800 mg/kg N/R KODAK* 21MAY1971
skin
rabbit 		lowest published lethal dose: 794 mg/kg Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Other changes

Blood: Hemorrhage 		NTIS** OTS0570629


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 100 mg/m3/5 hour/16 week- intermittent Blood: Changes in other cell count (unspecified)

Musculoskeletal: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVGH* -,604,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 2 ppm (skin DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 41,213,1986
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 41,213,1986
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1503,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1503,1999


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 ppm (28 mg/m3) (skin) DTLVS* 3,166,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 ppm (28 mg/m3) (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 ppm (28 mg/m3) (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 ppm (28 mg/m3) (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 ppm (28 mg/m3) (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 2 ppm (10 mg/m3), Skin, Carcinogen, JAN1993
Occupational Exposure Limit - AUSTRIA Skin, Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 2 ppm (12 mg/m3), Skin, Carcinogen JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (5.6 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 5 ppm (28 mg/m3), short term exposure limit 10 ppm (56 mg/m3), Skin, JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 1 ppm (5 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3, Skin, 2003
Occupational Exposure Limit - POLAND MAC(time-weighted average) 10 mg/m3, MAC(short term exposure limit) 30 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 1 ppm (6 mg/m3), KTV 5 ppm (30 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.3 ppm (2 mg/m3), Skin, Carcinogen, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 2 ppm (12 mg/m3), Skin, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 2 ppm (skin
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 2 ppm (skin


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL IODIDE-air Carcinogen;
10 hour time-weighted average 2 ppm (Sk) (1.7 ppm LOQ) 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0422;
Number of Industries 2;
Total Number of Facilities 26;
Number of Occupations 4;
Total Number of Employees Exposed 413
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0422;
Number of Industries 2;
Total Number of Facilities 34;
Number of Occupations 6;
Total Number of Employees Exposed 2,182;
Total Number of Female Employees Exposed 440


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat; SHE-clonal assay
EPA GENETOX PROGRAM 1988, Positive: L5178Y cells in vitro-TK test; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in fire extinguishers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 43, 1984
NIOSH Analytical Method, 1994: Methyl iodide, 1014


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IJCNAW International Journal of Cancer. (International Union Against Cancer, 3 rue du Conseil- General, 1205 Geneva, Switzerland) V.1- 1966-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGH* "Vrednie chemichescie veshestva, galogenproisvodnie uglevodorodov". (Hazardous substances: Galogenated hydrocarbons) Bandman A.L. et al., Chimia, 1990.
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

Used in fire extinguishers

RTECS Compound Description:
   Tumorigen
   Mutagen
   Primary Irritant

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