The Registry of Toxic Effects of Chemical Substances

Methane, tetranitro -

RTECS #: PB4025000

CAS #: 509-14-8

UPDATE: May 2005 MW: 196.05 MF: CN4O8


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. NCI - C55947
  2. RCRA waste number P112
  3. TNM
  1. Tetan
  2. Tetranitromethane
  3. Tetranitromethane (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 20 mg/L NTPTR* NTP-TR-386,1990
DNA damage rat liver 70 µmol/L MUREAV 368,59,1996
mutation in microorganisms Escherichia coli 500 µg/plate (+enzymatic activation step) SAIGBL 29,34,1987
mutation in microorganisms Salmonella typhimurium 2 µg/plate (+enzymatic activation step) ENMUDM 9(Suppl 9),1,1987
sister chromatid exchange hamster ovary 1,700 µg/L NTPTR* NTP-TR-386,1990


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 500 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NTPTR* NTP-TR-386,1990
inhalation
mouse 		toxic concentration (other than lowest) : 500 ppb/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		CALEDQ 57,95,1991
inhalation
mouse 		lowest published toxic concentration: 30.9 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB91-113373
inhalation
rat 		lowest published toxic concentration: 2 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		NTPTR* NTP-TR-386,1990
inhalation
rat 		toxic concentration (other than lowest) : 2 ppm/6 hour/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Bronchogenic carcinoma 		CALEDQ 57,95,1991
inhalation
rat 		lowest published toxic concentration: 61.8 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB91-113373
inhalation
rat 		lowest published toxic concentration: 51.5 mg/kg/103 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB91-113373


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 100 ppm/20 minute N/R 85JCAE -,403,1986
inhalation
mouse 		lethal concentration (50 percent kill): 54 ppm/4 hour Blood: Methemoglobinemia- Carboxhemoglobinemia NTIS** AD-A051-334
inhalation
rat 		lethal concentration (50 percent kill): 18 ppm/4 hour Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
intraperitoneal
mammal (species unspecified) 		lowest published lethal dose: 500 mg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia COREAF 171,1396,1920
intraperitoneal
mouse 		lethal dose (50 percent kill): 53 mg/kg N/R KHFZAN 10(6),53,1976
intravenous
mouse 		lethal dose (50 percent kill): 63,100 µg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
intravenous
rat 		lethal dose (50 percent kill): 12,600 µg/kg Blood: Methemoglobinemia- Carboxhemoglobinemia AMRL** TR-77-25,1977
oral
mouse 		lethal dose (50 percent kill): 375 mg/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity) 		NTIS** AD-A051-334
oral
rat 		lethal dose (50 percent kill): 130 mg/kg Olfaction: Other olfaction effects

Eye: Other eye effects

Behavioral: Somnolence (general depressed activity) 		NTIS** AD-A051-334


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 25 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-386,1990
inhalation
mouse 		lowest published toxic concentration: 10 ppm/6 hour/13 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight 		NTPTR* NTP-TR-386,1990
inhalation
rat 		lowest published toxic concentration: 6,350 ppb/6 hour/26 week- intermittent Olfaction: Other olfaction effects

Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		AMIHBC 10,213,1954
inhalation
rat 		lowest published toxic concentration: 25 ppm/6 hour/14 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field NTPTR* NTP-TR-386,1990
inhalation
rat 		lowest published toxic concentration: 10 ppm/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Other changes

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTPTR* NTP-TR-386,1990


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.005 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Confirmed Animal Carcinogen with Unknown DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Sufficient Evidence IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 65,437,1996
International Agency for Research on Cancer (IARC) Cancer Review Group 2B IMEMDT 65,437,1996


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 1 ppm (8 mg/m3) DTLVS* 3,254,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 1 ppm (8 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 1 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 1 ppm (8 mg/m3), short term exposure limit 3 ppm (24 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 1 ppm (8 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.04 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.04 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.3 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 ppm (0.4 mg/,3), KTV 0.2 ppm (0.8 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 1 ppm (8 mg/m3), Carcinogen, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 1 ppm (8 mg/m3), JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Confirmed Animal Carcinogen with Unknown
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Confirmed Animal Carcinogen with Unknown


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRANITROMETHANE-air 10 hour time-weighted average 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X7237;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 1,445;
Total Number of Female Employees Exposed 230


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as solvent for polymers and as stabilizer
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetranitromethane, 3513
NCI Carcinogenesis Studies (inhal);clear evidence:mouse,rat
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
AMRL** Aerospace Medical Research Laboratory Report. (Aerospace Technical Div., Air Force Systems Command, Wright-Patterson Air Force Base, OH 45433)
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
KHFZAN Khimiko-Farmatsevticheskii Zhurnal. Chemical Pharmaceutical Journal. For English translation, see PCJOAU. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-

Used as solvent for polymers and as stabilizer

NIOSH PROFILE (NITROPARAFFINS), SRC, 11/81

RTECS Compound Description:
   Tumorigen
   Mutagen

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