The Registry of Toxic Effects of Chemical Substances

Methylamine, m - phenylenebis -

RTECS #: PF8970000

CAS #: 1477-55-0

UPDATE: November 2004 MW: 136.22 MF: C8H12N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. 1,3 - Benzenedimethanamine
  2. 1,3 - Bis (aminomethyl) benzene
  3. 1,3 - Bis - aminomethylbenzen (Czech)
  4. MXDA
  5. m - Phenylenebis (methylamine)
  1. m - Xylene alpha,alpha' - diamine
  2. m - Xylene alpha,alpha' - diamine (ACGIH)
  3. m - Xylene - alpha,alpha' - diamine
  4. m - Xylylendiamin (Czech)
  5. m - Xylylenediamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,447,1986
skin
rabbit 		750 µg/24 hour severe 85JCAE -,447,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 700 ppm/1 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Respiratory depression 		85INA8 5,638,1986
oral
rat 		lethal dose (50 percent kill): 930 mg/kg N/R 85INA8 5,638,1986
skin
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R 85INA8 5,638,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value ceiling concentration 0.1 mg/m3 (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 1 mg/m3, JAN1993
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.02 ppm (0.1 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VLE 0.1 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC- continuous 0.1 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

ceiling concentration 0.1 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
ceiling concentration 0.1 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO m-XYLENE-alpha,alpha'-DIAMINE-air ceiling concentration 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84031;
Number of Industries 1;
Total Number of Facilities 5;
Number of Occupations 2;
Total Number of Employees Exposed 15
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 84031;
Number of Industries 3;
Total Number of Facilities 43;
Number of Occupations 4;
Total Number of Employees Exposed 1,005


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a curing agent for epoxy resins and as a source of m-XYLENE DIISOCYANATE
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, PROPOSED RULE FEREAC 47,27009,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #105


REFERENCES:

CODEN
REFERENCE
85INA8 "Documentation of the Threshold Limit Values and Biological Exposure Indices," 5th ed., Cincinnati, OH, American Conference of Governmental Industrial Hygienists, Inc., 1986
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.

Used as a curing agent for epoxy resins and as a source of m-XYLENE DIISOCYANATE

RTECS Compound Description:
   Primary Irritant

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