The Registry of Toxic Effects of Chemical Substances

1,5 - Naphthalenediamine

RTECS #: QJ3400000

CAS #: 2243-62-1

UPDATE: August 2003 MW: 158.22 MF: C10H10N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. 1,5 - Diaminonaphthalene
  2. 1,5 - Naphthylenediamine
  1. NCI - C03021


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 33,300 ng/plate (+/-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
morphological transform rat embryo 5,200 ng/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 120 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors 		NCITR* NCI-TR-143,1978
oral
mouse 		toxic dose : 288 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors 		NCITR* NCI-TR-143,1978
oral
mouse 		toxic dose : 721 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors 		IMEMDT 27,127,1982
oral
mouse 		toxic dose : 1,442 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Endocrine: Thyroid tumors 		IMEMDT 27,127,1982
oral
rat 		lowest published toxic dose: 721 gm/kg/1 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Tumors 		IMEMDT 27,127,1982
oral
rat 		toxic dose : 18 gm/kg/88 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-143,1978
oral
rat 		toxic dose : 54 gm/kg/2 year- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors

Reproductive: Tumorigenic effects: Uterine tumors 		NCITR* NCI-TR-143,1978
oral
rat 		toxic dose : 361 gm/kg/1 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Endocrine: Tumors 		IMEMDT 27,127,1982


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 27,127,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 27,127,1982
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
ARPTDI 43,309,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4423;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 28


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Carcinogenicity-mouse/rat
Used as an intermediate for the manufacture of 1,5-NAPHTHALENE DIISOCYANATE and organic dyes
NCI Carcinogenesis Bioassay (feed);clear evidence:mouse,rat NCITR* NCI-TR-143,1978


REFERENCES:

CODEN
REFERENCE
ARPTDI Annual Review of Pharmacology and Toxicology. (Annual Reviews, Inc., POB 10139, Palo Alto, CA 94303) V.16- 1976-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.

Used as an intermediate for the manufacture of 1,5-NAPHTHALENE DIISOCYANATE and organic dyes

RTECS Compound Description:
   Tumorigen
   Mutagen

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