The Registry of Toxic Effects of Chemical Substances

Nitrogen dioxide

RTECS #: QW9800000

CAS #: 10102-44-0

UPDATE: May 2005 MW: 46.01 MF: NO2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Azote (French)
  2. Azoto (Italian)
  3. Nitrito
  4. RCRA waste number P078
  1. Nitrogen dioxide (ACGIH:OSHA)
  2. Nitrogen peroxide
  3. Stickstoffdioxid (German)
  4. Stikstofdioxyde (Dutch)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 10 ppm/10 minute- continuous MUREAV 89,303,1981
cytogenetic analysis inhalation
rat 		27 ppm/3 hour- continuous MUREAV 136,119,1984
DNA adduct inhalation
rat 		108 mg/kg/300 day- intermittent CALEDQ 139,189,1999
DNA damage hamster lung 10 ppm CRNGDP 11,37,1990
unscheduled DNA synthesis inhalation
rat 		30 ppm/1 hour ENVRAL 27,352,1982
mutation in microorganisms Escherichia coli 198 µg/L (-enzymatic activation step) MUREAV 162,1,1986
mutation in microorganisms Salmonella typhimurium 6 ppm (+enzymatic activation step) MUREAV 136,119,1984
mutation in microorganisms Salmonella typhimurium 5 ppm (-enzymatic activation step) EMMUEG 11,65,1988
mutation in mammalian somatic cells inhalation
rat 		15 ppm/3 hour- continuous MUREAV 136,119,1984
other mutation test systems Escherichia coli 297 µg/L MUREAV 162,1,1986
other mutation test systems Salmonella typhimurium 50 ppm MUREAV 192,239,1987
sister chromatid exchange hamster lung 5 ppm/10 minute- continuous MUREAV 89,303,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic dose: 22 ppm (7-18 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		NRTXDN 9,545,1988
inhalation
rat 		lowest published toxic concentration: 10 mg/m3/6 hour (1-22 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTOTDY 7,785,1985
inhalation
rat 		lowest published toxic concentration: 85 µg/m3/24 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		GISAAA 42(12),22,1977
inhalation
rat 		lowest published toxic concentration: 800 µg/m3/24 hour (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) GISAAA 42(12),22,1977
inhalation
rat 		lowest published toxic concentration: 2,360 µg/m3/12 hour (12 week prior to copulation) Reproductive: Maternal effects: Menstrual cycle changes or disorders

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		HYSAAV 36(7-9),178,1971
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/6 hour (1-22 day pregnant) Reproductive: Effects on newborn: Behavioral NTOTDY 7,785,1985
inhalation
rat 		lowest published toxic concentration: 40 pph (8-10 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		VCVN5* -,37,1989
inhalation
rat 		lowest published toxic concentration: 40 pph (12-16 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Other developmental abnormalities 		VCVN5* -,37,1989


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 108 mg/kg/300 day- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Tumorigenic: Facilitates action of known carcinogens

Lung, Thorax, or Respiration: Tumors 		CALEDQ 139,189,1999


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 123 mg/m3/8 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 9,160,1966
inhalation
dog 		lowest published lethal concentration: 110 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		VCVN5* -,35,1993
inhalation
dog 		lowest published toxic concentration: 19 mg/m3/6 hour Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,35,1993
inhalation
dog 		lowest published toxic concentration: 37.2 ppm/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema EXMPA6 33,90,1980
inhalation
guinea pig 		lethal concentration (50 percent kill): 30 ppm/1 hour Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Lung, Thorax, or Respiration: Respiratory stimulation

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AEHLAU 10,220,1965
inhalation
guinea pig 		lethal concentration (50 percent kill): 900 mg/m3/30 minute N/R VCVN5* -,28,1993
inhalation
human 		lowest published lethal concentration: 200 ppm/1 minute N/R AOHYA3 17,159,1974
inhalation
human 		lowest published toxic concentration: 200 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,28,1993
inhalation
human 		lowest published toxic concentration: 90 mg/m3/15 minute Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough

Gastrointestinal: Changes in structure or function of salivary glands 		VCVN5* -,28,1993
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3 Olfaction: Change in sensation of smell

Lung, Thorax, or Respiration: Cough 		VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 0.14 mg/m3/5 hour Eye: Other eye effects VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 0.59 mg/m3/5 minute Brain and Coverings: Changes in surface EEG VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 14 mg/m3 Eye: Conjunctiva irritation VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 120 mg/m3 Lung, Thorax, or Respiration: Dyspnea VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 70 mg/m3 Behavioral: Muscle weakness VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 38 mg/m3/2 hour Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 510 mg/m3/5 minute Lung, Thorax, or Respiration: Other changes VCVN5* -,36,1993
inhalation
human 		lowest published toxic concentration: 950 mg/m3/5 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,36,1993
inhalation
man 		lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes 		INHTE5 11,89,1999
inhalation
man 		lowest published toxic concentration: 6,200 ppb/10 minute Lung, Thorax, or Respiration: Changes in pulmonary vascular resistance KEKHA7 17,337,1968
inhalation
man 		lowest published toxic concentration: 90 ppm/40 minute Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		JOCMA7 8,301,1966
inhalation
monkey 		lowest published lethal concentration: 123 mg/m3/8 hour Olfaction: Other olfaction effects

Eye: Other eye effects

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 9,160,1966
inhalation
monkey 		lowest published lethal concentration: 95 mg/m3/2 hour N/R VCVN5* -,36,1993
inhalation
mouse 		lethal concentration (50 percent kill): 1,000 ppm/10 minute Behavioral: Convulsions or effect on seizure threshold

Behavioral: Change in motor activity (specific assay) 		JCTODH 4,246,1977
inhalation
mouse 		lethal concentration (50 percent kill): 800 mg/m3/25 minute N/R VCVN5* -,28,1993
inhalation
mouse 		lethal concentration (50 percent kill): 900 mg/m3/2 hour N/R VCVN5* -,35,1993
inhalation
mouse 		lowest published toxic concentration: 9.5 mg/m3/1 hour Blood: Normocytic anemia

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVN5* -,35,1993
inhalation
rat 		lethal concentration (50 percent kill): 88 ppm/4 hour N/R AMIHBC 10,418,1954
inhalation
rat 		lethal concentration (50 percent kill): 220 mg/m3/1 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat 		lethal concentration (50 percent kill): 310 mg/m3/30 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat 		lethal concentration (50 percent kill): 790 mg/m3/5 minute Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/17 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 32 mg/m3/2 hour Lung, Thorax, or Respiration: Ciliary function changes

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 25 mg/m3/2 hour Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 22.7 mg/m3/4 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Endocrine: Other changes 		VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 1.9 mg/m3/4 hour Lung, Thorax, or Respiration: Other changes VCVN5* -,35,1993
inhalation
rat 		lowest published toxic concentration: 20 ppm/20 hour Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 6,149,1980
inhalation
rat 		lowest published toxic concentration: 200 ppm/15 minute Lung, Thorax, or Respiration: Respiratory obstruction

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport 		TXAPA9 184,1,2002
inhalation
rabbit 		lethal concentration (50 percent kill): 315 ppm/15 minute Lung, Thorax, or Respiration: Respiratory depression

Eye: Conjunctiva irritation 		AIHAAP 23,457,1962
inhalation
rabbit 		lethal concentration (50 percent kill): 60 mg/m3/15 minute N/R VCVN5* -,35,1993
inhalation
rabbit 		lethal concentration (50 percent kill): 12 mg/m3/15 minute Eye: Conjunctiva irritation VCVN5* -,35,1993
inhalation
rabbit 		lowest published toxic concentration: 28 mg/m3/3 hour Immunological Including Allergic: Decrease in cellular immune response VCVN5* -,35,1993


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 5,800 µg/m3/4 hour/17 week- intermittent Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		TPKVAL 15,53,1979
inhalation
guinea pig 		lowest published toxic concentration: 15 ppm/24 hour/10 week- continuous Kidney, Ureter, and Bladder: Other changes

Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		AEHLAU 10,220,1965
inhalation
guinea pig 		lowest published toxic concentration: 3,284 µg/m3/8 hour/26 week- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		BCTKAG 8,241,1975
inhalation
guinea pig 		lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
guinea pig 		lowest published toxic concentration: 17 mg/m3/24 hour/4 week- continuous Lung, Thorax, or Respiration: Other changes

Liver: Other changes

Biochemical: Effect on specific coenzyme: Proportion of isoenzymes 		VCVN5* -,37,1989
inhalation
guinea pig 		lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
guinea pig 		lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
guinea pig 		lowest published toxic concentration: 5 ppm/2 hour/35 day- intermittent Brain and Coverings: Other degenerative changes

Biochemical: Metabolism (intermediary): Lipids including transport 		JPFCD2 B27,53,1992
inhalation
hamster 		lowest published toxic concentration: 30 ppm/22 hour/36 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi EXLRDA 11,179,1986
inhalation
human 		lowest published toxic concentration: 1.9 mg/m3/2 hour/3 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVN5* -,36,1989
inhalation
human 		lowest published toxic concentration: 0.8 mg/m3/3 year- intermittent Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Blood: Change in clotting factors 		VCVN5* -,38,1989
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 10 ppm/4 hour/15 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Lung, Thorax, or Respiration: Other changes 		TOLED5 73,241,1994
inhalation
monkey 		lowest published toxic concentration: 9.5 mg/m3/24 hour/8 week- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,36,1989
inhalation
monkey 		lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
monkey 		lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
mouse 		lowest published toxic concentration: 250 ppb/7 hour/7 week- intermittent Blood: Changes in spleen

Immunological Including Allergic: Decrease in cellular immune response 		JTEHD6 25,247,1988
inhalation
mouse 		lowest published toxic concentration: 20 ppm/24 hour/4 day- continuous Endocrine: Changes in spleen weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response 		ENVRAL 42,446,1987
inhalation
mouse 		lowest published toxic concentration: 10 ppm/2 hour/30 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Blood: Pigmented or nucleated red blood cells 		ENVRAL 19,154,1979
inhalation
mouse 		lowest published toxic concentration: 500 ppb/30 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi NKYZA2 10,16,1972
inhalation
mouse 		lowest published toxic concentration: 5.7 mg/m3/2 hour/15 week- intermittent Blood: Normocytic anemia

Immunological Including Allergic: Decrease in cellular immune response 		VCVN5* -,37,1989
inhalation
mouse 		lowest published toxic concentration: 5.7 mg/m3/2 hour/1 year- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,37,1989
inhalation
mouse 		lowest published toxic concentration: 9.5 mg/m3/6 hour/1 year- intermittent Lung, Thorax, or Respiration: Tumors VCVN5* -,37,1989
inhalation
mouse 		lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
mouse 		lowest published toxic concentration: 0.7 ppm/2 hour/3 day- intermittent Lung, Thorax, or Respiration: Other changes JTEHD6 65,1999,2002
inhalation
rat 		lowest published toxic concentration: 2 ppm/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		JTEHD6 15,23,1985
inhalation
rat 		lowest published toxic concentration: 5,800 µg/m3/4 hour/17 week- intermittent Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		TPKVAL 15,53,1979
inhalation
rat 		lowest published toxic concentration: 16 ppm/23 hour/74 week- continuous Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Changes in lung weight 		ARDSBL 121,541,1980
inhalation
rat 		lowest published toxic concentration: 5,700 µg/m3/6 hour/26 week- intermittent Endocrine: Other changes GISAAA 26(12),79,1961
inhalation
rat 		lowest published toxic concentration: 3 ppm/24 hour/39 week- continuous Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Metabolism (intermediary): Lipids including transport 		AEHLAU 26,156,1973
inhalation
rat 		lowest published toxic concentration: 2 ppm/24 hour/1 year- continuous Lung, Thorax, or Respiration: Changes in lung weight AEHLAU 17,181,1968
inhalation
rat 		lowest published toxic concentration: 4 ppm/24 hour/14 week- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation) 		ENVRAL 41,184,1986
inhalation
rat 		lowest published toxic concentration: 8 ppm/24 hour/7 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		AECTCV 15,733,1986
inhalation
rat 		lowest published toxic concentration: 5 ppm/24 hour/4 week- continuous Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		BECTA6 40,139,1988
inhalation
rat 		lowest published toxic concentration: 10 ppm/3 day- continuous Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decrease in cellular immune response 		TOLED5 121,135,2001
inhalation
rat 		lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/24 hour/2 week- continuous Behavioral: Change in motor activity (specific assay)

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Emphysema 		VCVN5* -,37,1989
inhalation
rat 		lowest published toxic concentration: 17 mg/m3/4 hour/10 day- intermittent Lung, Thorax, or Respiration: Other changes VCVN5* -,37,1989
inhalation
rat 		lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/5 day/39 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVN5* -,38,1989
inhalation
rat 		lowest published toxic concentration: 5 mg/m3/5 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		VCVN5* -,38,1989
inhalation
rat 		lowest published toxic concentration: 3.8 mg/m3/24 hour/2 year- continuous Lung, Thorax, or Respiration: Ciliary function changes VCVN5* -,38,1989
inhalation
rat 		lowest published toxic concentration: 2.4 mg/m3/12 hour/13 week- intermittent Endocrine: Effect on menstrual cycle VCVN5* -,38,1989
inhalation
rat 		lowest published toxic concentration: 0.9 mg/m3/6 hour/13 week- intermittent Immunological Including Allergic: Decreased immune response VCVN5* -,38,1989
inhalation
rat 		lowest published toxic concentration: 0.6 mg/m3/24 hour/13 week- continuous Peripheral Nerve and Sensation: Recording from peripheral motor nerve

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial) 		VCVN5* -,38,1989
inhalation
rabbit 		lowest published toxic concentration: 68 mg/m3/8 hour/6 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989
inhalation
rabbit 		lowest published toxic concentration: 22 mg/m3/24 hour/90 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,37,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 3 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 5 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
FEPRA7 35,89,1976
TOXICOLOGY REVIEW
NTIS** PB228-002
TOXICOLOGY REVIEW
CTOXAO 7,145,1974
TOXICOLOGY REVIEW
AEHLAU 16,903,1968
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
AEHLAU 12,522,1966
TOXICOLOGY REVIEW
XPHBAO 272,1,1941


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD air-ceiling concentration 5 ppm (9 mg/m3) DTLVS* 3,185,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) ceiling concentration 5 ppm (9 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 3 ppm (6 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 3 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 3 99m (5.6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 3 ppm (6 mg/m3), short term exposure limit 6 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VLE 3 ppm (6 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 5 ppm (9 mg/m3), JAN1999
Occupational Exposure Limit - JAPAN Occupational Exposure Limit Pending, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 4 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 2 ppm (4 mg/m3), TGV 5 ppm (13 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 3 ppm (6 mg/m3), KZG- week 6 ppm (12 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 5 ppm (9 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 3 ppm (5.7 mg/m3), short term exposure limit 5 ppm (9.6 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 5 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 5 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITROGEN DIOXIDE-air short term exposure limit 1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50870;
Number of Industries 16;
Total Number of Facilities 424;
Number of Occupations 19;
Total Number of Employees Exposed 11,419
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50870;
Number of Industries 5;
Total Number of Facilities 94;
Number of Occupations 24;
Total Number of Employees Exposed 18,737;
Total Number of Female Employees Exposed 1,773


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an industrial chemical and chemical intermediate
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
OSHA ANALYTICAL METHOD #ID-109
OSHA ANALYTICAL METHOD #ID-182


REFERENCES:

CODEN
REFERENCE
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
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DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
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XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an industrial chemical and chemical intermediate

NIOSH PROFILE (DIESEL EMISSIONS), SRI, 2/77

NIOSH PROFILE (FIREFIGHTING), FIRL, 4/78

NIOSH PROFILE (INCINERATION), FIRL, 4/78

NIOSH PROFILE (WELDING AND BRAZING), SRC, 10/77

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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