The Registry of Toxic Effects of Chemical Substances

Nitrogen monoxide

RTECS #: QX0525000

CAS #: 10102-43-9

UPDATE: February 2005 MW: 30.01 MF: NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Amidogen, oxo -
  2. Bioxyde d'azote (French)
  3. Nitric oxide
  4. Nitric oxide (ACGIH:OSHA)
  5. Nitric oxide trimer
  1. Nitrosyl radical
  2. Oxyde nitrique (French)
  3. RCRA waste number P076
  4. Stickmonoxyd (German)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 30 ppm (+enzymatic activation step) MUREAV 136,119,1984
mutation in mammalian somatic cells hamster fibroblast 10 ppm MUREAV 136,119,1984
mutation in mammalian somatic cells inhalation
rat 		27 ppm/3 hour- continuous MUREAV 136,119,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published lethal concentration: 5,000 ppm/25 minute Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Methemoglobinemia- Carboxhemoglobinemia 		BJANAD 39,393,1967
inhalation
human 		lowest published toxic concentration: 76 mg/m3 Behavioral: Muscle weakness VCVN5* -,32,1993
inhalation
mouse 		lowest published lethal concentration: 320 ppm Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Cyanosis

Blood: Methemoglobinemia- Carboxhemoglobinemia 		AEPPAE 181,145,1936
inhalation
mouse 		lowest published toxic concentration: 6,000 mg/m3/4 minute Behavioral: Alteration of classical conditioning VCVN5* -,32,1993
inhalation
mouse 		lowest published lethal concentration: 6,000 mg/m3/6 minute N/R VCVN5* -,32,1993
inhalation
mouse 		lowest published toxic concentration: 3,000 mg/m3/6 minute Behavioral: Alteration of classical conditioning VCVN5* -,32,1993
inhalation
mouse 		lowest published lethal concentration: 3,000 mg/m3/12 minute N/R VCVN5* -,32,1993
inhalation
rat 		lethal concentration (50 percent kill): 1,068 mg/m3/4 hour N/R GTPZAB 19(4),52,1975
inhalation
rat 		lethal concentration (50 percent kill): 160 mg/m3 N/R VCVN5* -,32,1993
inhalation
rat 		lowest published toxic concentration: 140 mg/m3 Blood: Methemoglobinemia- Carboxhemoglobinemia VCVN5* -,32,1993
inhalation
rabbit 		lowest published toxic concentration: 10 pph/20 minute Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		CEXPB9 27,95,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
infant 		lowest published toxic concentration: 20 ppm/5 day- continuous Lung, Thorax, or Respiration: Other changes NEJMAG 342,469,2000
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 50 mg/m3/6 hour/7 week- intermittent Blood: Normocytic anemia VCVN5* -,33,1989
inhalation
mouse 		lowest published toxic concentration: 10 ppm/2 hour/30 week- intermittent Lung, Thorax, or Respiration: Emphysema

Blood: Pigmented or nucleated red blood cells

Blood: Changes in leukocyte (WBC) count 		ENVRAL 19,154,1979
inhalation
rat 		lowest published toxic concentration: 200 ppm/6 hour/7 day- intermittent Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Methemoglobinemia- Carboxhemoglobinemia 		TOXID9 42,253,1998
inhalation
rat 		lowest published toxic concentration: 50 mg/m3/6 hour/7 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 19(4),52,1975
inhalation
rat 		lowest published toxic concentration: 3 mg/m3/24 hour/16 day- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 48(9),69,1983
inhalation
rat 		lowest published toxic concentration: 160 ppm/6 hour/4 week- intermittent Blood: Methemoglobinemia- Carboxhemoglobinemia TOXID9 42,253,1998
inhalation
rat 		lowest published toxic concentration: 14 mg/m3/24 hour/17 week- continuous Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count 		VCVN5* -,33,1989
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/3240 hour- continuous Lung, Thorax, or Respiration: Emphysema

Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes primarily in glomeruli 		VCVN5* -,33,1989
inhalation
rabbit 		lowest published toxic concentration: 14 mg/m3/24 hour/17 week- continuous Cardiac: EKG changes not diagnostic of above

Blood: Changes in erythrocyte (RBC) count 		VCVN5* -,33,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
CTOXAO 7,145,1974
TOXICOLOGY REVIEW
XPHBAO 272,1,1941
TOXICOLOGY REVIEW
TOLED5 1391632003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 25 ppm (30 mg/m3) DTLVS* 3,182,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 25 ppm (30 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRIA MAK 25 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - DENMARK time-weighted average 25 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 25 ppm (30 mg/m3), KTV 50 ppm (60 mg/m3), JAN1999
Occupational Exposure Limit - THAILAND time-weighted average 25 ppm (30 mg/m3), JAN1993
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 30 mg/m3, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO NITRIC OXIDE-air 10 hour time-weighted average 25 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 50745;
Number of Industries 11;
Total Number of Facilities 276;
Number of Occupations 11;
Total Number of Employees Exposed 1,354
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 50745;
Number of Industries 3;
Total Number of Facilities 59;
Number of Occupations 16;
Total Number of Employees Exposed 14,332;
Total Number of Female Employees Exposed 6,183


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Nitric oxide and nitrogen dioxide, 6014
OSHA ANALYTICAL METHOD #ID-109


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
BJANAD British Journal of Anesthesia. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.1- 1923-
CEXPB9 Clinical and Experimental Pharmacology and Physiology. (Blackwell Scientific Publications, (Australia) Pty Ltd., 107 Barry St., Carlton, Vic. 3053, Australia) V.1- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CTOXAO Clinical Toxicology. (New York, NY) V.1-18, 1968-81. For publisher information, see JTCTDW.
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

NIOSH PROFILE (INCINERATION), FIRL, 4/78

RTECS Compound Description:
   Mutagen
   Human Data

ALT CAS #: 51005-21-1
ALT CAS #: 90452-29-2
ALT CAS #: 90880-94-7
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