The Registry of Toxic Effects of Chemical Substances
Octyl alcohol RTECS #: RH6550000
CAS #: 111-87-5
The Registry of Toxic Effects of Chemical Substances
Octyl alcohol |
| UPDATE: February 2005 | MW: 130.26 | MF: C8H18O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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skin | rabbit
500 mg/24 hour
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mild
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FCTXAV 11,1079,1973
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
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REFERENCE
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sex chromosome loss and nondisjunction
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hamster
lung
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800 µmol/L
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MUREAV 182,135,1987
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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inhalation | human
lowest published toxic concentration: 0.1 ppm/4 hour
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Cardiac: Pulse rate decreased with fall in BP | Lung, Thorax, or Respiration: Other changes
NRTXDN 24,179,2003
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inhalation | rat
lowest published lethal concentration: 5,600 mg/m3/4 hour
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Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi | Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion Blood: Hemorrhage
EPASR* 8EHQ-1088-0762
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intraperitoneal | rat
lowest published toxic dose: 2,000 mg/kg
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Behavioral: Ataxia | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
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intravenous | mouse
lethal dose (50 percent kill): 69 mg/kg
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N/R
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AIPTAK 135,330,1962
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oral | human
lowest published lethal dose: 428.6 mg/kg
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N/R
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VCVGK* -,116,1984
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oral | mouse
lethal dose (50 percent kill): 1,790 mg/kg
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N/R
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HYSAAV 31(1-3),310,1966
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oral | mouse
lethal dose (50 percent kill): 15,000 mg/kg
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Brain and Coverings: Other degenerative changes | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
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oral | rat
lethal dose (50 percent kill): >3,200 mg/kg
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N/R
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FCTXAV 11,95,1973
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oral | rat
lethal dose (50 percent kill): 20,000 mg/kg
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Brain and Coverings: Other degenerative changes | Liver: Other changes Kidney, Ureter, and Bladder: Other changes
VCVGK* -,115,1984
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parenteral | frog
lowest published lethal dose: 1,240 mg/kg
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Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change | Behavioral: Somnolence (general depressed activity)
AIPTAK 50,296,1935
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skin | guinea pig
lethal dose (50 percent kill): >1 gm/kg
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N/R
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FCTXAV 11,95,1973
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unreported route | mammal (species unspecified)
lethal dose (50 percent kill): 4 gm/kg
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N/R
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GISAAA 51(5),61,1986
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
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TOLED5 140-141,261,2003
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988
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PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION
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FEREAC 54,7740,1989
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Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF
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PESTICIDES: Cancelled
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RBREV* -,292,1998
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Occupational Exposure Limit - RUSSIA
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short term exposure limit 10 mg/m3, JAN1993
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
National Occupational Hazard Survey 1974
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National Occupational Hazard Survey 1974: Hazard Code: 80235; | Number of Industries 29; Total Number of Facilities 1,071; Number of Occupations 32; Total Number of Employees Exposed 13,905
National Occupational Exposure Survey 1983
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National Occupational Exposure Survey 1983: Hazard Code: 80235 |
 ;Number of Industries 133; Total Number of Facilities 9,310; Number of Occupations 93; Total Number of Employees Exposed 287,737; Total Number of Female Employees Exposed 72,792 | ||||
STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
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Used as solvent, OCTYL CHLORIDE intermediate, specialty ethoxylate intermediate, defoamer
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EPA TSCA Section 8(d) unpublished health/safety studies
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EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
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REFERENCES:
CODEN
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REFERENCE
AIPTAK
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Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of
Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
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EPASR*
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United States Environmental Protection Agency, Office of Pesticides and Toxic Substances.
(U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
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FCTXAV
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Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see
FCTOD7.
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FEREAC
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Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
V.1- 1936-
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GISAAA
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Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga,
113095 Moscow, USSR) V.1- 1936-
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HYSAAV
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Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71.
Discontinued.
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MUREAV
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Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1-
1964-
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NRTXDN
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Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
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RBREV*
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Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report),
Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental
Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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VCVGK*
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"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia".
(Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia,
1994.
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