The Registry of Toxic Effects of Chemical Substances

Ozone

RTECS #: RS8225000

CAS #: 10028-15-6

UPDATE: May 2005 MW: 48.00 MF: O3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. NIOSH DOCUMENTATION AND SURVEILLANCE:
  11. STATUS IN FEDERAL AGENCIES:
  12. REFERENCES:

SYNONYMS:

  1. Ozon (Polish)
  2. Ozone (ACGIH:OSHA)
  1. Triatomic oxygen


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		2 ppm/4 hour N/R JPCAAC 10,17,1960


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis chicken fibroblast 1 µg/L/30 minute ZEKBAI 67,113,1965
cytogenetic analysis inhalation
hamster 		200 ppb/5 hour ENVRAL 4,262,1971
cytogenetic analysis inhalation
hamster 		0.38 µg/L/5 hour VCVN5* -,166,1989
cytogenetic analysis inhalation
human 		500 ppb/6 hour MEHYDY 4,165,1978
cytogenetic analysis human leukocyte 7,230 ppb/1 hour ENVRAL 12,188,1976
cytogenetic analysis human other cell types 8 ppm/5 minute- continuous NATUAS 194,793,1962
cytogenetic analysis inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
cytogenetic analysis inhalation
rat 		28 mg/m3/5 day- continuous GISAAA 44(9),12,1979
cytogenetic analysis inhalation
rat 		0.5 ppb EMMUEG 39,69,2002
dominant lethal test inhalation
other insects 		30 ppm/3 hour- continuous ENMUDM 4,657,1982
DNA adduct inhalation
guinea pig 		0.4 ppm/2 hour INHTE5 9,811,1997
DNA adduct inhalation
human 		0.4 ppm/2 hour INHTE5 9,811,1997
DNA damage Escherichia coli 500 µg/L AIPAAV 114,595,1968
DNA damage human other cell types 0.9 mmol/L/1 hour MUREAV 517,13,2002
DNA damage mouse fibroblast 25 mmol/L BIJOAK 247,69,1987
DNA damage inhalation
mouse 		1 ppm/90 minute MUREAV 520,63,2002
DNA damage other microorganisms 70 pph JOHYAY 78,199,1977
DNA inhibition hamster lung 2 ppm/1 hour JTEHD6 17,119,1986
DNA repair Escherichia coli 50 ppm/30 minute BBRCA9 77,220,1977
mutation in microorganisms Escherichia coli 50 ppm (-enzymatic activation step) MGGEAE 197,472,1984
mutation in microorganisms Salmonella typhimurium 19 ppb/35 minute (+enzymatic activation step) EMMUEG 17(Suppl 19),22,1991
mutation in microorganisms Salmonella typhimurium 3 mg/L (-enzymatic activation step) OZSEDS 8,217,1986
morphological transform hamster embryo 5 ppm CRNGDP 7,1611,1986
morphological transform mouse fibroblast 5 ppm CRNGDP 7,1611,1986
phage inhibition capacity Escherichia coli 50 ppm CNJGA8 26,706,1984
sister chromatid exchange human lung 250 ppb/1 hour- continuous ENVRAL 18,336,1979
specific locus test inhalation
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test inhalation
rat 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 2 mg/m3 (9-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		VCVN5* -,166,1989
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 2 mg/m3 (17-20 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Behavioral 		VCVN5* -,166,1989
inhalation
rat 		lowest published toxic concentration: 1,040 ppb/24 hour (6-9 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		TXAPA9 48,19,1979
inhalation
rat 		lowest published toxic concentration: 1,500 ppb/24 hour (17-20 day pregnant) Reproductive: Effects on newborn: Behavioral

Reproductive: Effects on newborn: Physical 		TOLED5 5,3,1980
inhalation
rat 		lowest published toxic concentration: 3 ppm (5 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 16,269,2002
inhalation
rat 		lowest published toxic concentration: 3 ppm (10 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina REPTED 16,269,2002


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published toxic concentration: 5 ppm/2 hour/75 day- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		AEHLAU 20,16,1970
inhalation
mouse 		toxic concentration (other than lowest) : 608 µg/m3/24 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		JJIND8 75,771,1985
inhalation
mouse 		toxic concentration (other than lowest) : 1 ppm/6 hour/2 year- intermittent Tumorigenic: Neoplastic by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTPTR* NTP-TR-440,1994
inhalation
mouse 		lowest published toxic concentration: 44.1 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB95-226999
inhalation
mouse 		lowest published toxic concentration: 88.2 mg/kg/105 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors 		NTIS** PB95-226999
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/12 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Reproductive: Maternal effects: Ovaries, fallopian tubes 		VHTODE 43,370,2001


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lethal concentration (50 percent kill): 34,500 ppb/3 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		IMSUAI 25,301,1956
inhalation
cat 		lethal concentration (50 percent kill): 7 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
dog 		lowest published toxic concentration: 0.2 mg/m3/1 hour Endocrine: Other changes VCVN5* -,163,1993
inhalation
domestic animal 		lowest published toxic concentration: 1 mg/m3/3 hour Blood: Methemoglobinemia- Carboxhemoglobinemia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		VCVN5* -,163,1993
inhalation
guinea pig 		lethal concentration (50 percent kill): 24,800 ppb/3 hour Lung, Thorax, or Respiration: Other changes IMSUAI 26,63,1957
inhalation
guinea pig 		lethal concentration (50 percent kill): 7 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
guinea pig 		lowest published toxic concentration: 1 mg/m3/2 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
guinea pig 		lowest published toxic concentration: 0.2 mg/m3/1 hour Brain and Coverings: Other degenerative changes

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		VCVN5* -,163,1993
inhalation
hamster 		lethal concentration (50 percent kill): 10,500 ppb/4 hour N/R AMIHAB 15,181,1957
inhalation
human 		lowest published lethal concentration: 50 ppm/30 minute Behavioral: Headache

Vascular: BP lowering not characterized in autonomic section

Lung, Thorax, or Respiration: Dyspnea 		34ZIAG -,446,1969
inhalation
human 		lowest published toxic concentration: 100 ppm/1 minute Lung, Thorax, or Respiration: Other changes

Skin: After systemic exposure: Dermatitis, other 		NEACA9 19,686,1941
inhalation
human 		lowest published toxic concentration: 1 ppm Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		AEHLAU 10,295,1965
inhalation
human 		lowest published toxic concentration: 200 ppb/4 hour/4 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes 		AJCMED 161,1855,2000
inhalation
human 		lowest published toxic concentration: 600 ppb/2 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		ARDSBL 118,287,1978
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Respiratory depression 		VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.6 mg/m3/3 hour Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.4 mg/m3 Olfaction: Change in sensation of smell VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.4 mg/m3/1 hour Behavioral: Alteration of classical conditioning VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.4 mg/m3/4 hour Eye: Changes in refraction

Eye: Visual field changes

Eye: Other eye effects 		VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.2 mg/m3/30 minute Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 2 mg/m3/1 hour Lung, Thorax, or Respiration: Respiratory depression VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 8 mg/m3 Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 20 mg/m3 Behavioral: Rigidity (includes catalepsy)

Behavioral: Headache

Cardiac: Pulse rate increased without fall in BP 		VCVN5* -,163,1993
inhalation
human 		lowest published toxic concentration: 0.6 ppm/2 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		EVHPAZ 108,533,2000
inhalation
human 		lowest published toxic concentration: 0.1 ppm/2 hour Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TOLED5 134,219,2002
inhalation
man 		lowest published toxic concentration: 80 ppb/6.6 hour Lung, Thorax, or Respiration: Cough

Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		AEHLAU 46,145,1991
inhalation
man 		lowest published toxic concentration: 1,860 ppb/75 minute Eye: Lacrimation

Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Cough 		AEHLAU 10,517,1965
inhalation
mouse 		lethal concentration (50 percent kill): 12,600 ppb/3 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		FEPRA7 16,22,1957
inhalation
mouse 		lethal concentration (50 percent kill): 46 mg/m3/2 hour N/R VCVN5* -,163,1993
inhalation
mouse 		lethal concentration (50 percent kill): 40 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
mouse 		lethal concentration (50 percent kill): 7.6 mg/m3/4 hour N/R VCVN5* -,163,1993
inhalation
mouse 		lethal concentration (50 percent kill): 4 mg/m3/24 hour N/R VCVN5* -,163,1993
inhalation
mouse 		lowest published toxic concentration: 1.6 mg/m3/3 hour Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		VCVN5* -,163,1993
inhalation
mouse 		lowest published toxic concentration: 0.1 mg/m3 Behavioral: Alteration of classical conditioning VCVN5* -,163,1993
inhalation
mouse 		lowest published toxic concentration: 0.8 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		EVHPAZ 108,533,2000
inhalation
mouse 		lowest published toxic concentration: 0.8 ppm/8 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Plasma proteins not involving coagulation 		EVHPAZ 108,533,2000
inhalation
mouse 		lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		TOXID9 72,63,2003
inhalation
mouse 		lowest published toxic concentration: 2 ppm/2 hour Cardiac: Pulse rate decreased with fall in BP

Nutritional and Gross Metabolic: Body temperature decrease 		EVHPAZ 109(Suppl 4),539,2001
inhalation
mouse 		lowest published toxic concentration: 1 ppm/1 hour Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Lung, Thorax, or Respiration: Sputum

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		TXCYAC 172,69,2002
inhalation
rat 		lethal concentration (50 percent kill): 4,800 ppb/4 hour Lung, Thorax, or Respiration: Acute pulmonary edema

Blood: Hemorrhage 		AMIHAB 15,181,1957
inhalation
rat 		lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes 		JTEHD6 46,329,1995
inhalation
rat 		lowest published toxic concentration: 0.8 ppm/3 hour Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JTEHD6 46,329,1995
inhalation
rat 		lethal concentration (50 percent kill): 28 mg/m3/2 hour N/R VCVN5* -,163,1993
inhalation
rat 		lethal concentration (50 percent kill): 4.5 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
rat 		lethal concentration (50 percent kill): 1 mg/m3/44 hour N/R VCVN5* -,163,1993
inhalation
rat 		lethal concentration : 0.5 mg/m3/1 hour N/R VCVN5* -,163,1993
inhalation
rat 		lowest published toxic concentration: 1.2 mg/m3/18 hour Lung, Thorax, or Respiration: Acute pulmonary edema VCVN5* -,163,1993
inhalation
rat 		lowest published toxic concentration: 0.65 mg/m3/6 hour Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		VCVN5* -,163,1993
inhalation
rat 		lowest published toxic concentration: 6.5 mg/m3/3 hour Behavioral: Alteration of classical conditioning

Lung, Thorax, or Respiration: Respiratory depression

Blood: Normocytic anemia 		VCVN5* -,163,1993
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/24 hour Endocrine: Other changes VCVN5* -,163,1993
inhalation
rat 		lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		EXLRDA 14,477,1988
inhalation
rat 		lowest published toxic concentration: 0.4 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease

Biochemical: Metabolism (intermediary): Lipids including transport 		INHTE5 6,267,1994
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/6 hour Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		EVHPAZ 109(Suppl 4),539,2001
inhalation
rat 		lowest published toxic concentration: 1,600 µg/m3/8 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JTEHD6 65,1571,2002
inhalation
rat 		lowest published toxic concentration: 2 ppm/4 hour Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		JTEHD6 65,1453,2002
inhalation
rat 		lowest published toxic concentration: 1 ppm/24 hour Brain and Coverings: Changes in surface EEG

Behavioral: Sleep 		TXCYAC 191,89,2003
inhalation
rabbit 		lethal concentration (50 percent kill): 36 ppm/3 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Other changes 		IMSUAI 25,301,1956
inhalation
rabbit 		lethal concentration (50 percent kill): 7.4 mg/m3/3 hour N/R VCVN5* -,163,1993
inhalation
woman 		lowest published toxic concentration: 350 ppb/75 minute Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes 		INHTE5 12,151,2000


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 0.75 ppm/2 day/24 hour- continuous Endocrine: Other changes EXPADD 28,105,1985
inhalation
domestic animal 		lowest published toxic concentration: 9.5 mg/m3/4 hour/6 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi VCVN5* -,165,1989
inhalation
guinea pig 		lowest published toxic concentration: 2 ppm/2 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Changes in lung weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 3,521,1977
inhalation
guinea pig 		lowest published toxic concentration: 800 µg/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 116,209,1992
inhalation
guinea pig 		lowest published toxic concentration: 0.6 mg/m3/24 hour/2 week- continuous Behavioral: Food intake (animal)

Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVN5* -,165,1989
inhalation
guinea pig 		lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,165,1989
inhalation
guinea pig 		lowest published toxic concentration: 0.6 mg/m3/24 hour/2 week- continuous Lung, Thorax, or Respiration: Changes in lung weight

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		VCVN5* -,166,1989
inhalation
human 		lowest published toxic concentration: 0.5 mg/m3/7 year- intermittent Cardiac: Arrythmias (indlucing changes in conduction)

Cardiac: Pulse rate decreased with fall in BP

Behavioral: Muscle weakness 		VCVN5* -,167,1989
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 8 mg/m3/24 hour/14 day- continuous Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVN5* -,166,1989
inhalation
monkey 		lowest published toxic concentration: 1,500 pph/8 hour/21 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 29,207,1985
inhalation
monkey 		lowest published toxic concentration: 400 ppb/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial) 		EXLRDA 12,57,1987
inhalation
monkey 		lowest published toxic concentration: 1.2 mg/m3/4 hour/4 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Multiple enzyme effects 		VCVN5* -,165,1989
inhalation
monkey 		lowest published toxic concentration: 1.2 mg/m3/8 hour/1 year- intermittent Blood: Other changes VCVN5* -,165,1989
inhalation
monkey 		lowest published toxic concentration: 0.3 mg/m3/8 hour/90 day- intermittent Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		VCVN5* -,165,1989
inhalation
monkey 		lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,165,1989
inhalation
monkey 		lowest published toxic concentration: 0.15 ppm/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 24,125,1985
inhalation
monkey 		lowest published toxic concentration: 0.3 ppm/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases

Biochemical: Metabolism (intermediary): Lipids including transport 		TOLED5 24,125,1985
inhalation
monkey 		lowest published toxic concentration: 0.64 ppm/8 hour/1 year- intermittent Blood: Other changes ENVRAL 32,445,1983
inhalation
mouse 		lowest published toxic concentration: 400 ppb/24 hour/14 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response 		ENVRAL 35,490,1984
inhalation
mouse 		lowest published toxic concentration: 1 ppm/24 hour/4 week- continuous Endocrine: Changes in thymus weight

Immunological Including Allergic: Decrease in humoral immune response

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPOEC 9,243,1989
inhalation
mouse 		lowest published toxic concentration: 608 µg/m3/26 week- intermittent Endocrine: Changes in spleen weight TOLED5 26,139,1985
inhalation
mouse 		lowest published toxic concentration: 300 ppb/3 day- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		EXLRDA 20,579,1994
inhalation
mouse 		lowest published toxic concentration: 2 mg/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVN5* -,164,1989
inhalation
mouse 		lowest published toxic concentration: 0.2 mg/m3/5 hour/100 day- intermittent Lung, Thorax, or Respiration: Other changes

Immunological Including Allergic: Decreased immune response 		VCVN5* -,165,1989
inhalation
mouse 		lowest published toxic concentration: 0.7 mg/m3/8 hour/1 year- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Blood: Changes in erythrocyte (RBC) count 		VCVN5* -,165,1989
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/5 day/4 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,370,2001
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/5 day/7 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VHTODE 43,370,2001
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in spleen weight 		VHTODE 43,370,2001
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Related to Chronic Data: Changes in testicular weight VHTODE 43,370,2001
inhalation
mouse 		lowest published toxic concentration: 0.5 ppm/5 day/12 week- continuous Cardiac: Changes in heart weight

Related to Chronic Data: Changes in ovarian weight 		VHTODE 43,370,2001
inhalation
quail 		lowest published toxic concentration: 3 mg/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases 		ENVRAL 54,39,1991
inhalation
rat 		lowest published toxic concentration: 950 ppb/8 hour/90 day- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Other changes 		TXAPA9 106,384,1990
inhalation
rat 		lowest published toxic concentration: 1,600 µg/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Other changes

Lung, Thorax, or Respiration: Changes in lung weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		JTEHD6 24,515,1988
inhalation
rat 		lowest published toxic concentration: 800 µg/m3/24 hour/3 day- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Dehydrogenases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Metabolism (intermediary): Other proteins 		TXAPA9 116,209,1992
inhalation
rat 		lowest published toxic concentration: 700 ppb/2 hour/28 day- intermittent Lung, Thorax, or Respiration: Respiratory depression

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JTEHD6 17,143,1986
inhalation
rat 		lowest published toxic concentration: 200 ppb/24 hour/12 week- continuous Lung, Thorax, or Respiration: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Cytochrome oxidases (indlucing oxidative phosphrylation)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases 		ENVRAL 42,425,1987
inhalation
rat 		lowest published toxic concentration: 750 ppb/24 hour/14 day- continuous Lung, Thorax, or Respiration: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JEPTDQ 3(5-6),247,1980
inhalation
rat 		lowest published toxic concentration: 2 mg/m3/24 hour/3 day- continuous Lung, Thorax, or Respiration: Changes in lung weight

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		VCVN5* -,164,1989
inhalation
rat 		lowest published toxic concentration: 1.96 mg/m3/5 hour/10 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) VCVN5* -,164,1989
inhalation
rat 		lowest published toxic concentration: 1.4 mg/m3/24 hour/7 day- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Lung, Thorax, or Respiration: Dyspnea 		VCVN5* -,165,1989
inhalation
rat 		lowest published toxic concentration: 0.4 mg/m3/24 hour/3 day- continuous Gastrointestinal: Other changes

Blood: Normocytic anemia 		VCVN5* -,165,1989
inhalation
rat 		lowest published toxic concentration: 0.25 mg/m3/24 hour/13 week- continuous Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Lung, Thorax, or Respiration: Fibrosis (interstitial)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN5* -,165,1989
inhalation
rat 		lowest published toxic concentration: 9 mg/m3/6 hour/13 week- intermittent Lung, Thorax, or Respiration: Changes in lung weight

Endocrine: Changes in thyroid weight

Related to Chronic Data: Changes in testicular weight 		VCVN5* -,165,1989
inhalation
rat 		lowest published toxic concentration: 0.7 mg/m3/24 hour/90 day- continuous Lung, Thorax, or Respiration: Emphysema

Lung, Thorax, or Respiration: Acute pulmonary edema

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVN5* -,165,1989
inhalation
rat 		lowest published toxic concentration: 3.9 mg/m3/24 hour/13 week- continuous Reproductive: Paternal effects: Testes, epididymis, sperm duct VCVN5* -,166,1989
inhalation
rat 		lowest published toxic concentration: 2.4 mg/m3/6 hour/4 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		VCVN5* -,166,1989
inhalation
rat 		lowest published toxic concentration: 0.48 ppm/4 hour/4 week- intermittent Lung, Thorax, or Respiration: Emphysema

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other enzymes 		NEZAAQ 39,757,1984
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/23 hour/5 day- continuous Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		EVHPAZ 109(Suppl 4),539,2001
inhalation
rat 		lowest published toxic concentration: 0.5 ppm/6 hour/5 day- intermittent Cardiac: Pulse rate decreased with fall in BP

Lung, Thorax, or Respiration: Other changes

Nutritional and Gross Metabolic: Body temperature decrease 		EVHPAZ 109(Suppl 4),539,2001
inhalation
rat 		lowest published toxic concentration: 0.25 ppm/4 hour/14 day- intermittent Blood: Other changes

Biochemical: Metabolism (intermediary): Effect on inflammation or mediation of inflammation 		ETOPFR 17,1,2004
inhalation
rabbit 		lowest published toxic concentration: 100 ppb/2 hour/13 day- intermittent Lung, Thorax, or Respiration: Other changes JTEHD6 21,27,1987
oral
rat 		lowest published toxic dose: 4 mg/kg/40 day- continuous Immunological Including Allergic: Decreased immune response VCVN5* -,165,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 ppm DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
MUREAV 558,7,2004
TOXICOLOGY REVIEW
NTIS** PB228-002
TOXICOLOGY REVIEW
AEHLAU 16,903,1968
TOXICOLOGY REVIEW
NTIS** CONF-691001
TOXICOLOGY REVIEW
TOLED5 140-141,195,2003
TOXICOLOGY REVIEW
TOLED5 140-141,281,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 ppm (0.2 mg/m3) DTLVS* 3,194,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 ppm (0.2 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.1 ppm (0.02 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 0.3 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM short term exposure limit 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 ppm (0.2 mg/m3), short term exposure limit 0.3 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.2 mg/m3), VLE 0.2 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 0.2 mg/m3, short term exposure limit 0.4 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.6 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA time-weighted average 0.1 ppm, short term exposure limit 0.1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.1 ppm (0.2 mg/m3), TGV 0.3 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.2 mg/m3), KZG- week 0.2 ppm (0.4 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.1 ppm (0.2 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM short term exposure limit 0.2 ppm (0.4 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OZONE-air ceiling concentration 0.1 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81651;
Number of Industries 54;
Total Number of Facilities 6,329;
Number of Occupations 53;
Total Number of Employees Exposed 32,552
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81651;
Number of Industries 70;
Total Number of Facilities 5,347;
Number of Occupations 67;
Total Number of Employees Exposed 72,134;
Total Number of Female Employees Exposed 32,361


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: In vivo cytogenetics-nonhuman bone marrow
EPA GENETOX PROGRAM 1988, Negative: In vivo SCE-nonhuman
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-nonhuman lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: In vivo cytogenetics-human lymphocyte
EPA GENETOX PROGRAM 1988, Inconclusive: Cytogenetics-male germ cell
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in purification of drinking water and preservation of goods in cold storage
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NTP Carcinogenesis Studies (inhalation);some evidence:mouse NTPTR* NTP-TR-440,1994
NCI Carcinogenesis Studies (inhal);equivocal evidence:mouse
NCI Carcinogenesis Studies (inhal);no evidence:rat
OSHA ANALYTICAL METHOD # ID214


REFERENCES:

CODEN
REFERENCE
34ZIAG "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969
AEHLAU Archives of Environmental Health. (Heldref Pub., 4000 Albemarle St., NW, Washington, DC 20016) V.1- 1960-
AIPAAV Annales de l'Institut Pasteur (Paris). (Paris, France) V.1-123, 1887-1972. For publisher information, see ANMBCM.
AJCMED American Journal of Respiratory and Critical Care Medicine. (American Lung Association, 1740 Broadway, New Youk, NY 10019) V. 149- 1994-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARDSBL American Review of Respiratory Disease. (American Lung Assoc., 1740 Broadway, New York, NY 10019) V.80- 1959-
BBRCA9 Biochemical and Biophysical Research Communications. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CNJGA8 Canadian Journal of Genetics and Cytology. (National Research Council of Canada, Publication Sales and Distribution, Ottawa ON K1A OR6, Canada) V.1- 1959-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
ETOPFR Environmental Toxicology and Pharmacology (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V.1- Feb.1996-
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
EXLRDA Experimental Lung Research. (Hemisphere Publishing, c/o Taylor & Francis 1900 Frost Road, Suite 101, Bristol, PA 19007) V.1- 1980-
EXPADD Experimental Pathology (1981). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.19- 1981-
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87.
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
INHTE5 Inhalation Toxicology. (Published by Taylor & Francis Health, 11 New Fetter Lane, London EC4P 4EE) V.1- 1989-
JEPOEC Journal of Environmental Pathology, Toxicology and Oncology. (Chem-Orbital, POB 134, Park Forest, IL 60466) V.5(4)- 1984-
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC.
JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ.
JOHYAY Journal of Hygiene. (Cambridge Univ. Press, 32 E. 57th St., New York, NY 10022) V.1- 1901-
JPCAAC Journal of the Air Pollution Control Association. (Air Pollution Control Assoc., POB 2861, Pittsburgh, PA 15230) V.5- 1955-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MEHYDY Medical Hypotheses. (Churchill Livingstone Inc., 1560 Broadway, New York, NY 10036) V.1- 1975-
MGGEAE Molecular and General Genetics. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.99- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NATUAS Nature. (Nature Subscription Dept., POB 1018, Manasguan, NJ 08736) V.1- 1869-
NEACA9 News Edition, American Chemical Society. (Easton, PA) V.18-19, 1940-41. For publisher information, see CENEAR.
NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
OZSEDS Ozone: Science & Engineering. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1979-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
VHTODE Veterinary and Human Toxicology. (American College of Veterinary and Comparative Toxicology, Publication Office, Comparative Toxicology, Manhattan, KS 66506) V.19- 1977-
ZEKBAI Zeitschrift fuer Krebsforschung. (Berlin, Fed. Rep. Ger.) V.1-75, 1903-71. For publisher information, see JCROD7.

Used in purification of drinking water and preservation of goods in cold storage

NIOSH PROFILE (OZONE), SRC, 10/77

NIOSH PROFILE (SEWAGE TREATMENT), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data
   Natural Product
   Primary Irritant

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