The Registry of Toxic Effects of Chemical Substances

Paraformaldehyde

RTECS #: RV0540000

CAS #: 30525-89-4

UPDATE: August 2003 MW: N/R MF: (CH2O)x


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Aldacide
  2. Flo - Mor
  1. Formagene
  2. Paraform


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 mg severe BIOFX*
skin
rabbit 		500 mg/24 hour severe BIOFX*


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform rat embryo 2,200 ng/plate JJATDK 1,190,1981


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,070 mg/m3/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0534623
oral
rat 		lethal dose (50 percent kill): 800 mg/kg N/R 28ZEAL 4,308,1969
skin
rabbit 		lowest published lethal dose: 10,000 mg/kg Behavioral: Somnolence (general depressed activity)

Skin: After topical application: Corrosive

Nutritional and Gross Metabolic: Body temperature decrease 		BIOFX*


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published toxic dose: 9 gm/kg/90 day- continuous Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 30,1,1986
oral
rat 		lowest published toxic dose: 9 gm/kg/90 day- continuous Behavioral: Fluid intake

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 30,1,1986
oral
rat 		lowest published toxic dose: 365 mL/kg/2 year- continuous Gastrointestinal: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXCYAC 56,79,1989


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
27ZTAP 3,108,1969


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,122,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M1528;
Number of Industries 5;
Total Number of Facilities 236;
Number of Occupations 19;
Total Number of Employees Exposed 1,872
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M1528;
Number of Industries 54;
Total Number of Facilities 8,271;
Number of Occupations 65;
Total Number of Employees Exposed 146,532;
Total Number of Female Employees Exposed 20,414


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991


REFERENCES:

CODEN
REFERENCE
27ZTAP "Clinical Toxicology of Commercial Products--Acute Poisoning," 3rd ed., Gleason, M.N., et al., eds., Baltimore, Williams and Wilkins, 1969
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXCYAC Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

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