The Registry of Toxic Effects of Chemical Substances

Pentaerythritol, tetranitrate

RTECS #: RZ2620000

CAS #: 78-11-5

UPDATE: February 2005 MW: 316.17 MF: C5H8N4O12


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Angicap
  2. Angitet
  3. Antora
  4. Arcotrate
  5. Baritrate
  6. CHOT
  7. 1,3 - Dinitrato - 2,2 - bis (nitratomethyl) propane
  8. Mycardol
  9. Myotrate 10
  10. 2,2 - Bis ( (nitrooxy) methyl) - 1,3 - propanediol dinitrate (ester)
  11. 2,2 - Bis (hydroxymethyl) - 1,3 - propanediol tetranitrate
  12. C 2 (explosive)
  13. Cardiacap
  14. C Hot
  15. Deltrate - 20
  16. Dilcoran 80
  17. Dipentrate
  18. Duotrate
  19. El PETN
  20. Erinit
  21. Extex
  22. Hasethrol
  23. Kaytrate
  24. Lentrat
  25. Lowetrate
  26. LX 02 - 1
  27. LX 08 - 0
  28. LX 16 (explosive)
  29. Martrate - 45
  30. Metranil
  31. Mikardol
  32. NCI - C55743
  33. Neo - corovas
  34. Neopentanetetrayl nitrate
  35. Niperyt
  36. Niperyth
  37. Nitrinol
  1. Nitropenta
  2. Nitropentaerythrite
  3. Nitropentaerythritol
  4. Pencard
  5. Pentanitrine
  6. Pentarit
  7. Penthrit
  8. Penthrite
  9. Pentrate
  10. Pentriol
  11. Pentritol
  12. Pentryate
  13. Pentryate 80
  14. Prevangor
  15. 1,3 - Propanediol, 2,2 - bis ( (nitrooxy) methyl) - , dinitrate (ester)
  16. Quintrate
  17. Rythritol
  18. SDM No. 23
  19. SDM No. 35
  20. Tranite D - lay
  21. Pentafin
  22. Pentestan - 80
  23. Pentetrate unicelles
  24. Pentitrate
  25. PETN
  26. Pergitral
  27. Peridex - LA
  28. Peritrate
  29. Perityl
  30. Subicard
  31. Tanipent
  32. Tentrate - 20
  33. Tetranitropentaerythrite
  34. Tetrasule
  35. Vasitol
  36. Vasodiatol
  37. Vaso - 80 unicelies


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition cattle mammary gland 3 µmol/L/24 hour MOCAE8 59,1044,2001
sister chromatid exchange hamster ovary 160 mg/L NTPTR* NTP-TR-365,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 12,875 mg/kg/2 year- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Olfaction: Tumors

Endocrine: Thyroid tumors 		NTPTR* NTP-TR-365,1989
oral
rat 		lowest published toxic dose: 1,092,000 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors 		NTIS** PB90-219452/AS
oral
rat 		lowest published toxic dose: 225,680 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Endocrine: Tumors 		NTIS** PB90-219452/AS


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): >5 gm/kg Vascular: Regional or general arteriolar or venous dilation AIPTAK 131,187,1961
intravenous
rat 		lethal dose (50 percent kill): 926 mg/kg N/R YAKUD5 9,759,1967
oral
man 		lowest published toxic dose: 1,669 mg/kg/8 year- continuous Skin: After systemic exposure: Dermatitis, other BJDEAZ 87,498,1972
oral
mouse 		lowest published lethal dose: 7 gm/kg N/R FRZKAP 16(2),63,1961
oral
rat 		lethal dose (50 percent kill): 1,660 mg/kg N/R YAKUD5 9,759,1967
oral
rabbit 		lowest published toxic dose: 50 mg/kg Vascular: BP lowering not characterized in autonomic section AEPPAE 364,269,2001


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rabbit 		lowest published toxic dose: 126 mg/kg/21 day- intermittent Vascular: Other changes AEPPAE 364,269,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MUREAV 543,201,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83538;
Number of Industries 1;
Total Number of Facilities 68;
Number of Occupations 6;
Total Number of Employees Exposed 2,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83538;
Number of Industries 4;
Total Number of Facilities 59;
Number of Occupations 8;
Total Number of Employees Exposed 2,650;
Total Number of Female Employees Exposed 1,267


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in manufacture of detonators and explosive specialties
NTP Carcinogenesis Studies (feed);equivocal evidence:rat NTPTR* NTP-TR-365,1989
NTP Carcinogenesis Studies (feed);no evidence:mouse NTPTR* NTP-TR-365,1989


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
BJDEAZ British Journal of Dermatology. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.63- 1951-
FRZKAP Farmatsevtichnii Zhurnal (Kiev). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.3- 1930-
MOCAE8 Molecular Carcinogenesis. (John Wiley & Sons, 605 Third Avenue, New York, NY 10158) V.1- 1988-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used in manufacture of detonators and explosive specialties

RTECS Compound Description:
   Tumorigen
   Drug
   Mutagen
   Human Data

ALT CAS #: 103842-90-6
ALT CAS #: 108736-71-6
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