RTECS:SA9100000 The Registry of Toxic Effects of Chemical Substances

The Registry of Toxic Effects of Chemical Substances

2 - Pentanone, 4 - hydroxy - 4 - methyl -

RTECS #: SA9100000

CAS #: 123-42-2

UPDATE: November 2004 MW: 116.18 MF: C₆H₁₂O₂

NOTE:

TOXICITY DATA HAVE NOT BEEN EVALUATED. OMISSION OF A SUBSTANCE OR NOTATION DOES NOT IMPLY ANY RELIEF FROM REGULATORY RESPONSIBILITY.

TABLE OF CONTENTS:

SYNONYMS:

SKIN AND EYE IRRITATION DATA:

ACUTE TOXICITY DATA:

OTHER MULTIPLE DOSE DATA:

REVIEWS:

STANDARDS AND REGULATIONS:

NIOSH DOCUMENTATION AND SURVEILLANCE:

STATUS IN FEDERAL AGENCIES:

REFERENCES:

SYNONYMS:

2 - Methyl - 2 - pentanol - 4 - one

4 - Hydroxy - 2 - keto - 4 - methylpentane

4 - Hydroxy - 4 - methyl pentan - 2 - one

4 - Hydroxy - 4 - methyl - 2 - pentanone

4 - Hydroxy - 4 - methyl - 2 - pentanone (OSHA)

4 - Hydroxy - 4 - methyl - pentan - 2 - on (German, Dutch)

4 - Hydroxy - 4 - methylpentanone - 2

4 - Idrossi - 4 - metil - pentan - 2 - one (Italian)

Diacetonalcohol (Dutch)

Diacetonalcool (Italian)

Diacetonalkohol (German)

Diacetone

Diacetone alcohol

Diacetone alcohol (ACGIH:OSHA)

Diacetone - alcool (French)

Diketone alcohol

Pyranton

Tyranton

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
eye
human 100 ppm/15 minute N/R JIHTAB 28,262,1946
eye
rabbit 20 mg severe AJOPAA 29,1363,1946
eye
rabbit 100 無/24 hour severe NTIS OTS0557741
skin
rabbit 10 mg/24 hour open irritation test severe JIHTAB 30,63,1948
skin
rabbit 500 mg open irritation test mild UCDS 6/29/1959

MUTATION DATA AND REFERENCES:
SYSTEM TEST ROUTE/
ORGANISM/
TISSUE DOSE REFERENCE
N/R N/R N/R N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
N/R
N/R N/R N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
cat lowest published toxic concentration: 100,000 mg/m³/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity) VCVGK* -,445,1994
inhalation
human lowest published toxic concentration: 100 ppm Eye: Other eye effects

Behavioral: Headache

Gastrointestinal: Nausea or vomiting NPIRI* 1,21,1974
inhalation
human lowest published toxic concentration: 400 ppm Lung, Thorax, or Respiration: Other changes NPIRI* 1,21,1974
inhalation
human lowest published toxic concentration: 475 mg/m³ Olfaction: Other olfaction effects

Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough VCVGK* -,445,1994
inhalation
human lowest published toxic concentration: 1,900 mg/m³ Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,445,1994
inhalation
mouse lowest published toxic concentration: 23,000 mg/m³ Brain and Coverings: Other degenerative changes VCVGK* -,445,1994
inhalation
mouse lowest published toxic concentration: 100,000 mg/m³/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity) VCVGK* -,445,1994
inhalation
rat lowest published lethal concentration: 1,000 ppm/4 hour N/R NTIS** OTS0557741
inhalation
rat lowest published toxic concentration: 100,000 mg/m³/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity) VCVGK* -,445,1994
inhalation
rabbit lowest published toxic concentration: 100,000 mg/m³/20 minute Eye: Conjunctiva irritation

Behavioral: Somnolence (general depressed activity) VCVGK* -,445,1994
intramuscular
rabbit lowest published lethal dose: 2,792 mg/kg Behavioral: Coma

Lung, Thorax, or Respiration: Respiratory depression JPETAB 33,175,1928
intraperitoneal
mouse lethal dose (50 percent kill): 933 mg/kg N/R SCCUR* -,3,1961
intravenous
rat lowest published lethal dose: 3,024 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Coma JPETAB 33,175,1928
intravenous
rabbit lowest published lethal dose: 2,792 mg/kg Lung, Thorax, or Respiration: Respiratory depression JPETAB 33,175,1928
oral
mouse lethal dose (50 percent kill): 3,950 mg/kg N/R JAPMA8 45,669,1956
oral
mouse lethal dose (50 percent kill): 3,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,445,1994
oral
rat lethal dose (50 percent kill): 2,520 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Liver: Other changes NTIS** OTS0557732
oral
rat lethal dose (50 percent kill): 4,000 mg/kg Behavioral: General anesthetic

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory depression VCVGK* -,445,1994
oral
rabbit lowest published lethal dose: 4,653 mg/kg Lung, Thorax, or Respiration: Respiratory depression JPETAB 33,175,1928
skin
rabbit lethal dose (50 percent kill): 13,500 mg/kg N/R NPIRI* 1,21,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/
ORGANISM DOSE
EFFECT

REFERENCE
inhalation
mammal (species unspecified) lowest published toxic concentration: 250 mg/m³/244 day- intermittent Brain and Coverings: Changes in surface EEG

Cardiac: EKG changes not diagnostic of above VCVGK* -,445,1994
inhalation
rat lowest published toxic concentration: 4,494 mg/m³/6 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Pigmented or nucleated red blood cells

Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** OTS0536235
inhalation
rat lowest published toxic concentration: 1,000 mg/m³/60 day- intermittent Cardiac: Arrythmias (indlucing changes in conduction) VCVGK* -,445,1994
inhalation
rat lowest published toxic concentration: 1,000 mg/m³/122 day- intermittent Brain and Coverings: Other degenerative changes VCVGK* -,445,1994
inhalation
rat lowest published toxic concentration: 1,000 mg/m³/244 day- intermittent Cardiac: Cardiomyopathy including infarction

Lung, Thorax, or Respiration: Other changes

Biochemical: Metabolism (intermediary): Other proteins VCVGK* -,445,1994
oral
rat lowest published toxic dose: 1,200 mg/kg/30 day- continuous Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) NTIS** OTS0557741
oral
rabbit lowest published toxic dose: 12 mL/kg/12 day- intermittent Behavioral: General anesthetic

Kidney, Ureter, and Bladder: Other changes

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field VCVGK* -,445,1994

REVIEWS:
ORGANIZATION STANDARD
REFERENCE

American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION STANDARD
REFERENCE

Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (240 mg/m³) DTLVS* 3,70,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (240 mg/m³) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (240 mg/m³) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (240 mg/m³) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (240 mg/m³) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 50 ppm (238 mg/m³), JAN1993
Occupational Exposure Limit - FINLAND time-weighted average 50 ppm (240 mg/m³), short term exposure limit 75 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE VME 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY MAK 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 25 ppm (120 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 120 mg/m³, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 100 mg/m³, JAN1993
Occupational Exposure Limit - SWEDEN NGV 25 ppm (120 mg/m³), KTV 20 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 50 ppm (241 mg/m³), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 50 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION STANDARD or SURVEY
REFERENCE

National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIACETONE ALCOHOL-air 10 hour time-weighted average 50 ppm NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M4016;
Number of Industries 191;
Total Number of Facilities 20,435;
Number of Occupations 95;
Total Number of Employees Exposed 167,915
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M4016;
Number of Industries 194;
Total Number of Facilities 20,857;
Number of Occupations 116;
Total Number of Employees Exposed 264,662;
Total Number of Female Employees Exposed 67,291

STATUS IN FEDERAL AGENCIES:
ORGANIZATION
REFERENCE

EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

REFERENCES:
CODEN
REFERENCE

AJOPAA American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI* Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

RTECS Compound Description:
Human Data
Primary Irritant

Click Here for Additional Information about RTECS

SYNONYMS:
2 - Methyl - 2 - pentanol - 4 - one 4 - Hydroxy - 2 - keto - 4 - methylpentane 4 - Hydroxy - 4 - methyl pentan - 2 - one 4 - Hydroxy - 4 - methyl - 2 - pentanone 4 - Hydroxy - 4 - methyl - 2 - pentanone (OSHA) 4 - Hydroxy - 4 - methyl - pentan - 2 - on (German, Dutch) 4 - Hydroxy - 4 - methylpentanone - 2 4 - Idrossi - 4 - metil - pentan - 2 - one (Italian) Diacetonalcohol (Dutch)	Diacetonalcool (Italian) Diacetonalkohol (German) Diacetone Diacetone alcohol Diacetone alcohol (ACGIH:OSHA) Diacetone - alcool (French) Diketone alcohol Pyranton Tyranton

SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
eye human	100 ppm/15 minute	N/R	JIHTAB 28,262,1946
eye rabbit	20 mg	severe	AJOPAA 29,1363,1946
eye rabbit	100 無/24 hour	severe	NTIS** OTS0557741
skin rabbit	10 mg/24 hour open irritation test	severe	JIHTAB 30,63,1948
skin rabbit	500 mg open irritation test	mild	UCDS** 6/29/1959

MUTATION DATA AND REFERENCES:
SYSTEM TEST	ROUTE/ ORGANISM/ TISSUE	DOSE	REFERENCE
N/R	N/R	N/R	N/R

REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

TUMORIGENIC DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
N/R	N/R	N/R	N/R

ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation cat	lowest published toxic concentration: 100,000 mg/m³/20 minute	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation human	lowest published toxic concentration: 100 ppm	Eye: Other eye effects Behavioral: Headache Gastrointestinal: Nausea or vomiting	NPIRI* 1,21,1974
inhalation human	lowest published toxic concentration: 400 ppm	Lung, Thorax, or Respiration: Other changes	NPIRI* 1,21,1974
inhalation human	lowest published toxic concentration: 475 mg/m³	Olfaction: Other olfaction effects Eye: Conjunctiva irritation Lung, Thorax, or Respiration: Cough	VCVGK* -,445,1994
inhalation human	lowest published toxic concentration: 1,900 mg/m³	Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
inhalation mouse	lowest published toxic concentration: 23,000 mg/m³	Brain and Coverings: Other degenerative changes	VCVGK* -,445,1994
inhalation mouse	lowest published toxic concentration: 100,000 mg/m³/20 minute	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation rat	lowest published lethal concentration: 1,000 ppm/4 hour	N/R	NTIS** OTS0557741
inhalation rat	lowest published toxic concentration: 100,000 mg/m³/20 minute	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
inhalation rabbit	lowest published toxic concentration: 100,000 mg/m³/20 minute	Eye: Conjunctiva irritation Behavioral: Somnolence (general depressed activity)	VCVGK* -,445,1994
intramuscular rabbit	lowest published lethal dose: 2,792 mg/kg	Behavioral: Coma Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
intraperitoneal mouse	lethal dose (50 percent kill): 933 mg/kg	N/R	SCCUR* -,3,1961
intravenous rat	lowest published lethal dose: 3,024 mg/kg	Behavioral: Somnolence (general depressed activity) Behavioral: Coma	JPETAB 33,175,1928
intravenous rabbit	lowest published lethal dose: 2,792 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
oral mouse	lethal dose (50 percent kill): 3,950 mg/kg	N/R	JAPMA8 45,669,1956
oral mouse	lethal dose (50 percent kill): 3,000 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
oral rat	lethal dose (50 percent kill): 2,520 mg/kg	Behavioral: Tremor Behavioral: Convulsions or effect on seizure threshold Liver: Other changes	NTIS** OTS0557732
oral rat	lethal dose (50 percent kill): 4,000 mg/kg	Behavioral: General anesthetic Behavioral: Somnolence (general depressed activity) Lung, Thorax, or Respiration: Respiratory depression	VCVGK* -,445,1994
oral rabbit	lowest published lethal dose: 4,653 mg/kg	Lung, Thorax, or Respiration: Respiratory depression	JPETAB 33,175,1928
skin rabbit	lethal dose (50 percent kill): 13,500 mg/kg	N/R	NPIRI* 1,21,1974

OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ ORGANISM	DOSE	EFFECT	REFERENCE
inhalation mammal (species unspecified)	lowest published toxic concentration: 250 mg/m³/244 day- intermittent	Brain and Coverings: Changes in surface EEG Cardiac: EKG changes not diagnostic of above	VCVGK* -,445,1994
inhalation rat	lowest published toxic concentration: 4,494 mg/m³/6 week- intermittent	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) Blood: Pigmented or nucleated red blood cells Nutritional and Gross Metabolic: Weight loss or decreased weight gain	NTIS** OTS0536235
inhalation rat	lowest published toxic concentration: 1,000 mg/m³/60 day- intermittent	Cardiac: Arrythmias (indlucing changes in conduction)	VCVGK* -,445,1994
inhalation rat	lowest published toxic concentration: 1,000 mg/m³/122 day- intermittent	Brain and Coverings: Other degenerative changes	VCVGK* -,445,1994
inhalation rat	lowest published toxic concentration: 1,000 mg/m³/244 day- intermittent	Cardiac: Cardiomyopathy including infarction Lung, Thorax, or Respiration: Other changes Biochemical: Metabolism (intermediary): Other proteins	VCVGK* -,445,1994
oral rat	lowest published toxic dose: 1,200 mg/kg/30 day- continuous	Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)	NTIS** OTS0557741
oral rabbit	lowest published toxic dose: 12 mL/kg/12 day- intermittent	Behavioral: General anesthetic Kidney, Ureter, and Bladder: Other changes Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field	VCVGK* -,445,1994

REVIEWS:
ORGANIZATION	STANDARD	REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value	time-weighted average 50 ppm	DTLVS* TLV/BEI,2003

STANDARDS AND REGULATIONS:
ORGANIZATION	STANDARD	REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air	time-weighted average 50 ppm (240 mg/m³)	DTLVS* 3,70,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry)	8 hour time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction)	8 hour time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards)	8 hour time-weighted average 50 ppm (240 mg/m³)	CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors)	8 hour time-weighted average 50 ppm (240 mg/m³)	CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA	time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit - AUSTRIA	MAK 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - BELGIUM	time-weighted average 50 ppm (238 mg/m³), JAN1993
Occupational Exposure Limit - FINLAND	time-weighted average 50 ppm (240 mg/m³), short term exposure limit 75 ppm (360 mg/m³), JAN1999
Occupational Exposure Limit - FRANCE	VME 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - GERMANY	MAK 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - NORWAY	time-weighted average 25 ppm (120 mg/m³), JAN1999
Occupational Exposure Limit - THE NETHERLANDS	MAC-TGG 120 mg/m³, 2003
Occupational Exposure Limit - RUSSIA	short term exposure limit 100 mg/m³, JAN1993
Occupational Exposure Limit - SWEDEN	NGV 25 ppm (120 mg/m³), KTV 20 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - SWITZERLAND	MAK- week 50 ppm (240 mg/m³), JAN1999
Occupational Exposure Limit - TURKEY	time-weighted average 50 ppm (240 mg/m³), JAN1993
Occupational Exposure Limit - UNITED KINGDOM	time-weighted average 50 ppm (241 mg/m³), short term exposure limit 75 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value; time-weighted average 50 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM	American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 50 ppm

NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION	STANDARD or SURVEY	REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIACETONE ALCOHOL-air	10 hour time-weighted average 50 ppm	NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974	National Occupational Hazard Survey 1974: Hazard Code: M4016; Number of Industries 191; Total Number of Facilities 20,435; Number of Occupations 95; Total Number of Employees Exposed 167,915
National Occupational Exposure Survey 1983	National Occupational Exposure Survey 1983: Hazard Code: M4016; Number of Industries 194; Total Number of Facilities 20,857; Number of Occupations 116; Total Number of Employees Exposed 264,662; Total Number of Female Employees Exposed 67,291

STATUS IN FEDERAL AGENCIES:
ORGANIZATION	REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Alcohols III, 1402

REFERENCES:
CODEN	REFERENCE
AJOPAA	American Journal of Ophthalmology. (Ophthalmic Pub. Co., 435 N. Michigan Ave., Suite 1415, Chicago, IL 60611) Series 3: V.1- 1918-
CFRGBR	Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS*	The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JAPMA8	Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE.
JIHTAB	Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB	Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
NIOSH*	National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NPIRI*	Raw Material Data Handbook, Vol.1: Organic Solvents, 1974. (National Assoc. of Printing Ink Research Institute, Francis McDonald Sinclair Memorial Laboratory, Lehigh Univ., Bethlehem, PA 18015)
NTIS**	National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SCCUR*	Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
UCDS**	Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)
VCVGK*	"Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.