The Registry of Toxic Effects of Chemical Substances

Pentyl alcohol

RTECS #: SB9800000

CAS #: 71-41-0

UPDATE: February 2003 MW: 88.17 MF: C5H12O


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Alcool amylique (French)
  2. Amylol
  3. Amyl alcohol
  4. n - Amyl alcohol
  5. Amyl alcohol, normal
  6. n - Amylalkohol (Czech)
  7. n - Pentanol
  1. 1 - Pentanol
  2. n - Butylcarbinol
  3. Pentanol
  4. Pentanol - 1
  5. Pentan - 1 - ol
  6. Primary amyl alcohol


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		81 mg severe AIHAAP 34,493,1973
eye
rabbit 		5 µL/24 hour severe NTIS** OTS0534716
skin
rabbit 		3,200 mg/24 hour severe AIHAAP 34,493,1973
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,196,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 7,000 ppm (-enzymatic activation step) ABMGAJ 23,843,1969
sex chromosome loss and nondisjunction hamster lung 25 mmol/L MUREAV 182,135,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration : >14 gm/m3/6 hour Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 34,493,1973
inhalation
human 		lowest published toxic concentration: 0.61 mg/m3 Brain and Coverings: Changes in surface EEG VCVGK* -,108,1984
inhalation
human 		lowest published toxic concentration: 0.4 mg/m3 Eye: Conjunctiva irritation

Lung, Thorax, or Respiration: Cough 		VCVGK* -,108,1984
inhalation
mouse 		lowest published lethal concentration: 14,000 mg/m3/6 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		AIHAAP 34,493,1973
inhalation
mouse 		lowest published lethal concentration: 14,000 mg/m3 N/R VCVGK* -,107,1984
inhalation
rat 		lowest published lethal concentration: 14,000 mg/m3/6 hour Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Acute pulmonary edema

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis) 		AIHAAP 34,493,1973
inhalation
rat 		lowest published lethal concentration: 14,000 mg/m3 N/R VCVGK* -,108,1984
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 615 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
hamster 		lethal dose (50 percent kill): 626 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
mouse 		lethal dose (50 percent kill): 970 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 579 mg/kg N/R EVHPAZ 61,321,1985
intraperitoneal
rat 		lowest published lethal dose: 450 mg/kg N/R VCVGK* -,108,1984
intraperitoneal
rabbit 		lethal dose (50 percent kill): 140 mg/kg N/R EVHPAZ 61,321,1985
intravenous
cat 		lowest published lethal dose: 15 mg/kg N/R VCVGK* -,108,1984
intravenous
mouse 		lethal dose (50 percent kill): 184 mg/kg N/R AIPTAK 135,330,1962
intravenous
rat 		lethal dose (50 percent kill): 196 mg/kg N/R EVHPAZ 61,321,1985
oral
dog 		lowest published lethal dose: 1,400 mg/kg Gastrointestinal: Other changes

Blood: Hemorrhage 		COREAF 81,192,1875
oral
human 		lowest published lethal dose: 142.8 mg/kg Brain and Coverings: Other degenerative changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		VCVGK* -,108,1984
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg Behavioral: General anesthetic GISAAA 35(9),88,1970
oral
mouse 		lethal dose (50 percent kill): 200 mg/kg N/R VCVGK* -,107,1984
oral
rat 		lethal dose (50 percent kill): 5,660 µL/kg Behavioral: Somnolence (general depressed activity) NTIS** OTS0534716
oral
rat 		lethal dose (50 percent kill): 370 mg/kg N/R VCVGK* -,107,1984
parenteral
frog 		lowest published lethal dose: 2 gm/kg Peripheral Nerve and Sensation: Spastic paralysis with/without sensory change

Behavioral: Somnolence (general depressed activity) 		AIPTAK 50,296,1935
subcutaneous
dog 		lowest published lethal dose: 1,800 mg/kg Gastrointestinal: Other changes

Blood: Hemorrhage 		COREAF 81,192,1875
skin
rabbit 		lethal dose (50 percent kill): 2,830 µL/kg Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		NTIS** OTS0534716
skin
rabbit 		lowest published lethal dose: 4,490 mg/kg N/R VCVGK* -,108,1984
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 1,174 mg/kg N/R GISAAA 51(5),61,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 10 mg/m3/24 hour/90 day- continuous Brain and Coverings: Other degenerative changes

Liver: Other changes

Lung, Thorax, or Respiration: Other changes 		VCVGK* -,108,1994
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 0.9 mg/m3/60 day- intermittent Eye: Other eye effects VCVGK* -,108,1994
inhalation
rat 		lowest published toxic concentration: 0.8 mg/m3/24 hour/30 day- continuous Eye: Optic nerve neuropathy

Olfaction: Change in olfactory nerve 		VCVGK* -,108,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 100 ppm (530 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA MAK 100 ppm (525 mg/m3) (all isomers), JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 100 ppm (532 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 100 ppm (360 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 100 ppm (360 mg/m3), short term exposure limit 150 ppm (540 mg/m3), JAN1999
Occupational Exposure Limit - FRANCE VME 100 ppm (530 mg/m3), short term exposure limit 150 ppm (800 mg/m3), JAN1993
Occupational Exposure Limit - GERMANY MAK 100 ppm (525 mg/m3) (all isomers), JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 400 mg/m3, short term exposure limit 800 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 100 ppm (530 mg/m3), JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 100 ppm (525 mg/m3), JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 100 mg/m3, MAC(short term exposure limit) 450 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 10 mg/m3, JAN1993
Occupational Exposure Limit - RUSSIA time-weighted average 100 ppm, short term exposure limit 100 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 100 ppm (540 mg/m3) (all isomers), JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 100 ppm (525 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 100 ppm (530 mg/m3), short term exposure limit 150 ppm, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: M0264;
Number of Industries 32;
Total Number of Facilities 892;
Number of Occupations 42;
Total Number of Employees Exposed 17,247
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: M0264;
Number of Industries 21;
Total Number of Facilities 3,107;
Number of Occupations 31;
Total Number of Employees Exposed 23,891;
Total Number of Female Employees Exposed 10,257


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in preparation of oil additives, plasticizers and synthetic lubricants, as a solvent
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
ABMGAJ Acta Biologica et Medica Germanica. (Berlin, Ger. Dem. Rep.) V.1-41, 1958-82. For publisher information, see BBIADT.
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898-
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used in preparation of oil additives, plasticizers and synthetic lubricants, as a solvent

NIOSH PROFILE (ALCOHOLS), SRI, 2/77

RTECS Compound Description:
   Mutagen
   Human Data
   Primary Irritant

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