The Registry of Toxic Effects of Chemical Substances

Phenol, 2 - sec - butyl - 4,6 - dinitro -

RTECS #: SJ9800000

CAS #: 88-85-7

UPDATE: February 2003 MW: 240.24 MF: C10H12N2O5


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. REVIEWS:
  9. STANDARDS AND REGULATIONS:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. Nitropone C
  2. Aatox
  3. Basanite
  4. Blaartox
  5. BNP 30
  6. Butaphen
  7. Butaphene
  8. 2 - sec - Butyl - 4,6 - dinitrophenol
  9. Caldon
  10. Chemox P.E.
  11. DBNF
  12. Desicoil
  13. Dibutox
  14. Dibutox 20CE
  15. 4,6 - Dinitro - 2 - sec.butylfenol (Czech)
  16. 2,4 - Dinitro - 6 - sec - butylphenol
  17. 4,6 - Dinitro - o - sec - butylphenol
  18. 4,6 - Dinitro - 2 - sec - butylphenol
  19. 4,6 - Dinitro - 2 - (1 - methyl - n - propyl) phenol
  20. Dinoseb
  21. Dinosebe (French)
  22. DN 289
  23. DNBP
  24. DNOSBP
  25. DNSBP
  1. Dow General Weed Killer
  2. Dow Selective Weed Killer
  3. Dytop
  4. ENT 1,122
  5. Hel - Fire
  6. Hivertox
  7. Kiloseb
  8. Ladob
  9. Laseb
  10. 6 - (1 - Methyl - propyl) - 2,4 - dinitrofenol (Dutch)
  11. 2 - (1 - Methylpropyl) - 4,6 - dinitrophenol
  12. 6 - (1 - Metil - propil) - 2,4 - dinitro - fenolo (Italian)
  13. Premerge
  14. RCRA waste number P020
  15. Sinox general
  16. Sparic
  17. Spurge
  18. Subitex
  19. Unicrop DNBP
  20. Vertac Dinitro Weed Killer
  21. Vertac General Weed Killer
  22. Vertac Selective Weed Killer
  23. WSX 8365
  24. Phenol, 2 - (1 - methylpropyl) - 4,6 - dinitro - (9CI)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		50 µg/24 hour severe 85JCAE -,679,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
gene conversion and mitotic recombination Saccharomyes cerevisiae 185 ppm MUREAV 21,83,1973


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 30 mg/kg (10-12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system FCTXAV 11,31,1973
intraperitoneal
mouse 		lowest published toxic dose: 47,400 µg/kg (10-12 day pregnant) Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system 		TJADAB 12,147,1975
intraperitoneal
mouse 		lowest published toxic dose: 37,500 µg/kg (14-16 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FCTXAV 11,31,1973
intraperitoneal
mouse 		lowest published toxic dose: 47,400 µg/kg (10-12 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JTEHD6 1,107,1975
intraperitoneal
rat 		lowest published toxic dose: 22,500 µg/kg (10-12 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FAATDF 11,381,1988
intraperitoneal
rat 		lowest published toxic dose: 27 mg/kg (10-12 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) JTEHD6 6,633,1980
intraperitoneal
rat 		lowest published toxic dose: 24 mg/kg (10-12 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		FAATDF 11,381,1988
oral
mouse 		lowest published toxic dose: 288 mg/kg (8-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) FCTXAV 11,31,1973
oral
mouse 		lowest published toxic dose: 26 mg/kg (8 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TCMUD8 5,3,1985
oral
mouse 		lowest published toxic dose: 100 mg/kg (7-8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJATDK 16,115,1996
oral
rat 		lowest published toxic dose: 1,201 mg/kg (77 day male) Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) AECTCV 11,475,1982
oral
rat 		lowest published toxic dose: 820 mg/kg (8 week male/8 week prior to copulation-22 day pregnant) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated)

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		TXAPA9 45,235,1978
oral
rat 		lowest published toxic dose: 820 mg/kg (8 week male/8 week prior to copulation-22 day pregnant) Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive)

Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4)

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		TXAPA9 45,235,1978
oral
rat 		lowest published toxic dose: 100 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear TJADAB 33,19A,1986
oral
rat 		lowest published toxic dose: 78 mg/kg (20 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) AECTCV 11,475,1982
oral
rat 		lowest published toxic dose: 150 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TJADAB 33,19A,1986
subcutaneous
mouse 		lowest published toxic dose: 53,100 µg/kg (14-16 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		FCTXAV 11,31,1973
subcutaneous
mouse 		lowest published toxic dose: 53,100 µg/kg (10-12 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system FCTXAV 11,31,1973


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 764 mg/kg/78 week- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Liver: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 45 mg/m3/3 hour N/R 85GMAT -,61,1982
intraperitoneal
mouse 		lethal dose (50 percent kill): 10 mg/kg N/R BCPCA6 18,1389,1969
intraperitoneal
rat 		lowest published toxic dose: 7.2 mg/kg Endocrine: Other changes ARTODN 65,15,1991
oral
wild bird 		lethal dose (50 percent kill): 7,100 µg/kg N/R TXAPA9 21,315,1972
oral
chicken 		lethal dose (50 percent kill): 26 mg/kg N/R 85JFAN A159,1984
oral
duck 		lethal dose (50 percent kill): 9 mg/kg N/R DOEAAH 35,25,1979
oral
guinea pig 		lethal dose (50 percent kill): 20 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 7,353,1965
oral
mouse 		lethal dose (50 percent kill): 16 mg/kg N/R 85GMAT -,61,1982
oral
rat 		lethal dose (50 percent kill): 25 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Respiratory stimulation 		TXAPA9 7,353,1965
oral
rat 		lowest published toxic dose: 17.5 mg/kg Related to Chronic Data: Changes in prostate weight REPTED 6,491,1992
subcutaneous
rat 		lethal dose (50 percent kill): 20,368 µg/kg N/R JPPMAB 4,1062,1952
skin
guinea pig 		lowest published lethal dose: 500 mg/kg N/R JIHTAB 30,10,1948
skin
mouse 		lowest published lethal dose: 40 mg/kg N/R TXAPA9 7,353,1965
skin
rat 		lethal dose (50 percent kill): 80 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lethal dose (50 percent kill): 80 mg/kg N/R PEMNDP 9,306,1991
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 60 mg/kg N/R 30ZDA9 -,98,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 72,800 µg/kg/26 week- intermittent Endocrine: Other changes

Blood: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GNAMAP 17,41,1978
oral
rat 		lowest published toxic dose: 87.5 mg/kg/5 day- intermittent Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 6,491,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
EVHPAZ 15,121,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae gene conversion
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for herbicide formulation
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
GNAMAP Gigiena Naselennykh Mest. Hygiene in Populated Places. (Izdatel'stvo Zdorov'ya, Kiev, USSR) V.7- 1967-
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TCMUD8 Teratogenesis, Carcinogenesis, and Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1980-
TJADAB Teratology, The International Journal of Abnormal Development. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1968-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

Used for herbicide formulation

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

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