The Registry of Toxic Effects of Chemical Substances
Phenol, 4 - octyl - RTECS #: SM5787000
CAS #: 1806-26-4
The Registry of Toxic Effects of Chemical Substances
Phenol, 4 - octyl - |
| UPDATE: November 2004 | MW: 206.33 | MF: C14H22O |
SYNONYMS:
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SKIN AND EYE IRRITATION DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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MUTATION DATA AND REFERENCES:
SYSTEM TEST
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ROUTE/ | ORGANISM/ TISSUE
DOSE
|
REFERENCE
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N/R
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N/R
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N/R
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N/R
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REPRODUCTIVE EFFECTS DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intravenous | domestic animal
lowest published toxic dose: 7,000 µg/kg (111-117 day pregnant)
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Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) | Reproductive: Other effects to embryo or fetus Reproductive: Specific developmental abnormalities: Urogenital system
JRFAB* Jul,19,2000
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oral | rat
lowest published toxic dose: 11,600 mg/kg (2 week prior to copulation-22 day after birth)
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Reproductive: Specific developmental abnormalities: Urogenital system
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EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 22 µg/kg (22 day after birth)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 220 µg/kg (22 day after birth)
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Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 570 µg/kg (2 week prior to copulation-22 week after birth)
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Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 1,130 µg/kg (10 week prior to copulation-22 day after birth)
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Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)
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EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 11.3 mg/kg (10 week prior to copulation-22 day after birth)
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Reproductive: Specific developmental abnormalities: Urogenital system | Reproductive: Effects on newborn: Delayed effects
EVHPAZ 103,1136,1995
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oral | rat
lowest published toxic dose: 7,250 mg/kg (1-22 day pregnant/7 day after birth)
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Reproductive: Specific developmental abnormalities: Central nervous system | Reproductive: Effects on newborn: Behavioral Reproductive: Effects on newborn: Physical
JRPFA4 26,25,2000
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subcutaneous | domestic animal
lowest published toxic dose: 60,000 µg/kg (60 day after birth)
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Reproductive: Effects on newborn: Germ cell effects (in offspring) | Reproductive: Effects on newborn: Delayed effects
JRFAB* Jul,18,2000
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TUMORIGENIC DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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N/R |
N/R
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N/R
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N/R
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ACUTE TOXICITY DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | rat
lowest published toxic dose: 60 mg/kg
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Liver: Other changes
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TXCYAC 175,49,2002
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OTHER MULTIPLE DOSE DATA AND REFERENCES:
ROUTE/ | ORGANISM
DOSE
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| EFFECT
REFERENCE
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intraperitoneal | rat
lowest published toxic dose: 600 mg/kg/10 day- intermittent
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Liver: Other changes | Biochemical: Metabolism (intermediary): Other proteins Related to Chronic Data: Changes in testicular weight
TXCYAC 175,49,2002
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oral | rat
lowest published toxic dose: 62.5 mg/kg/5 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Related to Chronic Data: Changes in prostate weight
REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 1,000 mg/kg/5 day- intermittent
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Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field
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REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent
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Reproductive: Effects on newborn: Physical
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REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent
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Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands
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REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 250 mg/kg/5 day- intermittent
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Reproductive: Maternal effects: Uterus, cervix, vagina
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REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 500 mg/kg/5 day- intermittent
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Nutritional and Gross Metabolic: Weight loss or decreased weight gain | Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field Related to Chronic Data: Changes in testicular weight
REPTED 15,683,2001
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oral | rat
lowest published toxic dose: 400 mg/kg/4 day- intermittent
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Reproductive: Maternal effects: Uterus, cervix, vagina
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REPTED 17,421,2003
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REVIEWS:
ORGANIZATION
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STANDARD
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REFERENCE
TOXICOLOGY REVIEW
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TOLED5 131,75,2002
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STANDARDS AND REGULATIONS:
ORGANIZATION
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STANDARD
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REFERENCE
N/R
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N/R
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N/R
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NIOSH DOCUMENTATION AND SURVEILLANCE:
ORGANIZATION
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STANDARD or SURVEY
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REFERENCE
N/R
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N/R
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N/R
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STATUS IN FEDERAL AGENCIES:
ORGANIZATION
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REFERENCE
N/R
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REFERENCES:
CODEN
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REFERENCE
EVHPAZ
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EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents,
Washington, DC 20402) No.1- 1972-
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JRFAB*
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Journal of reproduction and fertility. Abstract series. (Cambridge, U.K. : Journals of
Reproduction and Fertility Ltd. ; Colchester, U.K. : Biochemical Society Book Depot
(distributor)) V.1-26 1988-2000. Continued by: Reproduction (Cambridge, England). Abstract
series
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JRPFA4
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Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way,
Colchester, Essex CO2 8HP, UK) V.1- 1960-
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REPTED
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Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY
10523) V.1- 1987-
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TOLED5
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Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands)
V.1- 1977-
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TXCYAC
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Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973-
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