The Registry of Toxic Effects of Chemical Substances

Phenol, pentachloro - , sodium salt

RTECS #: SM6490000

CAS #: 131-52-2

UPDATE: November 2003 MW: 288.30 MF: C6Cl5O•Na


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Dow dormant fungicide
  2. Dowicide G
  3. Dowicide G - ST
  4. GR 48 - 11PS
  5. GR 48 - 32S
  6. Mystox D
  7. Napclor - G
  8. Pentachlorophenate sodium
  9. Pentachlorophenol, sodium salt
  10. Pentachlorophenol, sodium salt, aerosol
  11. Pentachlorophenol, sodium salt, technical grade
  12. Pentachlorophenoxy sodium
  13. Pentanot 25
  1. Pentaphenate
  2. Preventol PN
  3. Santobrite
  4. Sapco 25
  5. Sodium PCP
  6. Sodium pentachlorophenol
  7. Sodium pentachlorophenolate
  8. Sodium pentachlorophenoxide
  9. Sodium pentachlorphenate
  10. Sodium, (pentachlorophenoxy) -
  11. Weedbeads
  12. Witophen N


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 5 µg/disc MUREAV 40,19,1976
micronucleus test multiple
non-mammalian species 		10 µg/L/4 day- continuous MUREAV 465,145,2000
micronucleus test multiple
non-mammalian species 		100 µg/L/7 day- continuous MUREAV 465,145,2000


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 360 mg/kg (8-19 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		CHYCDW 13,8,1979


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 341 mg/m3/2 hour N/R 85GMAT -,106,1982
inhalation
mouse 		lethal concentration (50 percent kill): 240 mg/m3/2 hour N/R 85GMAT -,106,1982
inhalation
rat 		lethal concentration : 10 mg/kg/28 minute N/R HBPTO* 2,1486,2001
inhalation
rat 		lethal concentration : 14.5 mg/kg/44 minute N/R HBPTO* 2,1486,2001
intraperitoneal
mouse 		lethal dose (50 percent kill): 63,700 µg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Respiratory stimulation

Skin and Appendages: Other: Hair 		OSDIAF 5,119,1956
intraperitoneal
rabbit 		lowest published lethal dose: 50 mg/kg N/R JIHTAB 23,239,1941
intratracheal
guinea pig 		lowest published lethal dose: 120 mg/kg N/R MZUZA8 (9),29,1959
intratracheal
mouse 		lowest published lethal dose: 164 mg/kg N/R MZUZA8 (9),29,1959
intratracheal
rat 		lowest published lethal dose: 146 mg/kg N/R MZUZA8 (9),29,1959
intravenous
rabbit 		lowest published lethal dose: 22 mg/kg Vascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase 		JPETAB 76,104,1942
oral
guinea pig 		lowest published lethal dose: 250 mg/kg N/R MZUZA8 (9),29,1959
oral
mouse 		lethal dose (50 percent kill): 197 mg/kg N/R 85GMAT -,106,1982
oral
rat 		lethal dose (50 percent kill): 126 mg/kg N/R CHYCDW 13,8,1979
oral
rabbit 		lethal dose (50 percent kill): 328 mg/kg N/R MZUZA8 (9),29,1959
subcutaneous
dog 		lowest published lethal dose: 135 mg/kg N/R HBTXAC 5,125,1959
subcutaneous
mouse 		lowest published lethal dose: 56 mg/kg N/R HBTXAC 5,125,1959
subcutaneous
rat 		lethal dose (50 percent kill): 66 mg/kg Vascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase 		JPETAB 76,104,1942
subcutaneous
rabbit 		lowest published lethal dose: 100 mg/kg Vascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase 		JPETAB 76,104,1942
skin
guinea pig 		lowest published lethal dose: 266 mg/kg N/R HBTXAC 5,125,1959
skin
mouse 		lethal dose (50 percent kill): 124 mg/kg N/R 85GMAT -,106,1982
skin
rabbit 		lowest published lethal dose: 250 mg/kg Vascular: BP elevation not characterized in autonomic section

Endocrine: Hyperglycemia

Nutritional and Gross Metabolic: Body temperature increase 		JPETAB 76,104,1942


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lowest published toxic concentration: 500 mg/m3/13 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		MZUZA8 (9),29,1959
inhalation
mouse 		lowest published toxic concentration: 500 mg/m3/13 week- intermittent Liver: Fatty liver degeneration

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		MZUZA8 (9),29,1959
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		MZUZA8 (9),29,1959
inhalation
rat 		lowest published toxic concentration: 500 mg/m3/4 hour/90 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,249,1994
inhalation
rabbit 		lowest published toxic concentration: 500 mg/m3/13 week- intermittent Lung, Thorax, or Respiration: Fibrosis, focal (pneumoconiosis)

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		MZUZA8 (9),29,1959
oral
rat 		lowest published toxic dose: 84 mg/kg/28 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) HBPTO* 2,1493,2001


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,197,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 69270;
Number of Industries 49;
Total Number of Facilities 3,778;
Number of Occupations 46;
Total Number of Employees Exposed 23,402
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 69270;
Number of Industries 21;
Total Number of Facilities 1,439;
Number of Occupations 30;
Total Number of Employees Exposed 16,153;
Total Number of Female Employees Exposed 1,615


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a wood preservative, as a fungicide in water-based latex paint, and a herbicide
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HBTXAC "Handbook of Toxicology," 4 vols., Philadelphia, W.B. Saunders Co., 1956-59
JIHTAB Journal of Industrial Hygiene and Toxicology. (Cambridge, MA) V.18-31, 1936-49. For publisher information, see AEHLAU.
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-
OSDIAF Osaka Shiritsu Daigaku Igaku Zasshi. Journal of the Osaka City Medical Center. (Osaka, Japan) V.4-23, 1955-74. For publisher information, see OIGZDE.
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a wood preservative, as a fungicide in water-based latex paint, and a herbicide

NIOSH PROFILE (WOOD PRESERVING), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector

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