The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine

RTECS #: SS8050000

CAS #: 106-50-3

UPDATE: May 2005 MW: 108.16 MF: C6H8N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. p - Aminoaniline
  2. 4 - Aminoaniline
  3. BASF ursol D
  4. p - Benzenediamine
  5. 1,4 - Benzenediamine (9CI)
  6. Benzofur D
  7. C.I. 76060
  8. C.I. Developer 13
  9. C.I. Oxidation Base 10
  10. Developer 13
  11. Developer PF
  12. p - Diaminobenzene
  13. 1,4 - Diaminobenzene
  14. Durafur Black R
  15. p - Fenylendiamin (Czech)
  16. Fenylenodwuamina (Polish)
  17. Fouramine D
  18. Fourrine D
  19. Fourrine 1
  20. Fur Black 41867
  21. FUR Brown 41866
  1. Furro D
  2. Fur Yellow
  3. Futramine D
  4. Nako H
  5. Orsin
  6. Oxidation Base 10
  7. Paraphenylen - diamine
  8. Pelagol D
  9. Pelagol DR
  10. Pelagol Grey D
  11. Peltol D
  12. 1,4 - Phenylenediamine
  13. 6PPD
  14. Renal PF
  15. Rodol D
  16. Santoflex IC
  17. Tertral D
  18. Ursol D
  19. USAF EK - 394
  20. Zoba Black D
  21. p - Phenylenediamine (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
dog 		250 mg/24 hour mild JSCCA5 23,371,1972
skin
guinea pig 		250 mg/24 hour mild JSCCA5 23,371,1972
skin
human 		250 mg/24 hour mild JSCCA5 23,371,1972
skin
mouse 		250 mg/24 hour mild JSCCA5 23,371,1972
skin
pig 		250 mg/24 hour mild JSCCA5 23,371,1972
skin
rabbit 		12,500 µg/24 hour mild FCTXAV 15,607,1977
skin
rabbit 		250 mg/24 hour moderate JSCCA5 23,371,1972


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 15 mg/L EMMUEG 27,67,1996
DNA inhibition oral
mouse 		200 mg/kg MUREAV 46,305,1977
mutation in microorganisms Salmonella typhimurium 2 µmol/plate (+enzymatic activation step) 45OHAA -,170,1980
mutation in microorganisms Salmonella typhimurium 1 µg/plate (-enzymatic activation step) MUREAV 188,185,1987
morphological transform rat embryo 1,850 ng/plate JJATDK 1,190,1981
phage inhibition capacity Escherichia coli 125 µg/well MUREAV 260,349,1991
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		15,500 µmol/L/3 day MUREAV 48,181,1977


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
rat 		lowest published toxic dose: 2,625 mg/kg/30 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		KJMSAH 9,94,1958


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 920 mg/m3/4 hour Behavioral: General anesthetic

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Hematuria 		NTIS** OTS0530403
intraperitoneal
mouse 		lethal dose (50 percent kill): 50 mg/kg N/R NTIS** AD277-689
intraperitoneal
rat 		lethal dose (50 percent kill): 37 mg/kg N/R JTEHD6 2,657,1977
intraperitoneal
rabbit 		lowest published lethal dose: 150 mg/kg Lung, Thorax, or Respiration: Other changes JIDIAQ 42,473,1928
intravenous
dog 		lowest published lethal dose: 17 mg/kg N/R JIDHAN 4,386,1923
intravenous
rat 		lowest published lethal dose: 50 mg/kg N/R BSRSA6 41,302,1972
intravenous
rabbit 		lowest published lethal dose: 300 mg/kg Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		AIMDAP 36,724,1925
oral
wild bird 		lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983
oral
cat 		lowest published lethal dose: 100 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease 		JIDHAN 4,386,1923
oral
guinea pig 		lethal dose (50 percent kill): 145 mg/kg N/R GISAAA 53(7),62,1988
oral
man 		lowest published toxic dose: 71 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Acute pulmonary edema

Lung, Thorax, or Respiration: Dyspnea 		HUTODJ 8,345,1989
oral
mouse 		lowest published lethal dose: 100 mg/kg N/R GISAAA 23(5),14,1958
oral
quail 		lethal dose (50 percent kill): 100 mg/kg N/R AECTCV 12,355,1983
oral
rat 		lethal dose (50 percent kill): 80 mg/kg N/R JTEHD6 2,657,1977
oral
rabbit 		lowest published lethal dose: 250 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease 		JIDHAN 4,386,1923
subcutaneous
dog 		lowest published lethal dose: 100 mg/kg Behavioral: Coma

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Nausea or vomiting 		XPHBAO 271,40,1941
subcutaneous
mouse 		lowest published lethal dose: 140 mg/kg N/R JSCCA5 12,500,1961
subcutaneous
rat 		lowest published lethal dose: 170 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory stimulation 		JIDHAN 4,386,1923
subcutaneous
rabbit 		lowest published lethal dose: 200 mg/kg Cardiac: Pulse rate increased without fall in BP

Lung, Thorax, or Respiration: Respiratory stimulation

Nutritional and Gross Metabolic: Body temperature decrease 		JIDHAN 4,386,1923
skin
rabbit 		lowest published lethal dose: 5 gm/kg N/R JTEHD6 2,657,1977
unreported route
guinea pig 		lethal dose (50 percent kill): 145 mg/kg N/R GTPZAB 31(8),46,1987
unreported route
mouse 		lethal dose (50 percent kill): 331 mg/kg Brain and Coverings: Other degenerative changes GISAAA 50(6),78,1985
unreported route
rat 		lethal dose (50 percent kill): 133 mg/kg N/R GTPZAB 31(8),46,1987


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 375 mg/kg/5 day- continuous Behavioral: Food intake (animal)

Behavioral: Fluid intake 		FCTOD7 43,133,2005
oral
rat 		lowest published toxic dose: 1,050 mg/kg/30 week- intermittent Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Alteration of classical conditioning

Liver: Fatty liver degeneration 		GISAAA 23(5),14,1958
oral
rat 		lowest published toxic dose: 28 gm/kg/80 week- continuous Endocrine: Changes in spleen weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TOLED5 16,259,1983
oral
rat 		lowest published toxic dose: 16,800 mg/kg/12 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TOLED5 16,259,1983
oral
rabbit 		lowest published toxic concentration: 105 mg/kg/30 week- intermittent Behavioral: Somnolence (general depressed activity)

Liver: Fatty liver degeneration

Liver: Liver function tests impaired 		GISAAA 23(5),14,1958


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,125,1978
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 16,125,1978
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
JACTDZ 4(3),203,1985


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.1 mg/m3 (skin) DTLVS* 3,205,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.1 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.1 mg/m3, Skin, Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg/m3, short term exposure limit 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.1 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.1 mg/m3, MAC(short term exposure limit) 0.3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.1 mg/m3, KTV 0.3 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.1 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO p-PHENYLENE DIAMINE-air 10 hour time-weighted average 0.1 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 56950;
Number of Industries 9;
Total Number of Facilities 2,017;
Number of Occupations 11;
Total Number of Employees Exposed 14,983
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 56950;
Number of Industries 6;
Total Number of Facilities 5,390;
Number of Occupations 7;
Total Number of Employees Exposed 49,939;
Total Number of Female Employees Exposed 37,209


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-RLV F344 rat embryo
EPA GENETOX PROGRAM 1988, Positive: Cell transform.-SA7/SHE; D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat; Rodent dominant lethal
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Sperm morphology-mouse
EPA GENETOX PROGRAM 1988, Inconclusive: Mammalian micronucleus
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used in dyestuff manufacture, in hair dyes, and in photographic developers
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
OSHA ANALYTICAL METHOD #87


REFERENCES:

CODEN
REFERENCE
45OHAA "Short-Term Test Systems for Detecting Carcinogens, Proceedings of the Symposium, 1978," Norpoth, K.H., and R.G. Garner, eds., Berlin, Springer-Verlag, 1980
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
AIMDAP Archives of Internal Medicine. (AMA, 535 N. Dearborn St., Chicago, IL 60610) V.1- 1908-
BSRSA6 Bulletin de la Societe Royale des Sciences de Liege. (Societe Royale des Sciences de Liege, Universite de Liege, 15, Ave des Tilleuls, B-4000 Liege, Belgium) V.1- 1932-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HUTODJ Human Toxicology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants., RG 21 2XS, UK) V.1- 1981-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JIDIAQ Journal of Infectious Diseases. (Univ. of Chicago Press, Journals Div., POB 37005, Chicago, IL 60637) V.1- 1904-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
KJMSAH Kyushu Journal of Medical Science. (Fukuoka, Japan) V.6-15, 1955-64. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used in dyestuff manufacture, in hair dyes, and in photographic developers

NIOSH PROFILE (AMINES, PRIMARY AROMATIC), SRI, 2/77

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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