The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, N,N' - diphenyl -

RTECS #: ST2275000

CAS #: 74-31-7

UPDATE: September 2000 MW: 260.36 MF: C18H16N2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. TUMORIGENIC DATA:
  6. ACUTE TOXICITY DATA:
  7. OTHER MULTIPLE DOSE DATA:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Nocrac DP
  2. Nonflex H
  3. Nonox DPPD
  4. AgeRite DPPD
  5. Altofane DIP
  6. Antage DP
  7. Antigene P
  8. Antioxidant H
  9. 1,4 - Bis (phenylamino) benzene
  10. Diafen FF
  11. N,N' - Difenyl - p - fenylendiamin (Czech)
  12. Diphenyl - p - phenylenediamine
  1. N,N' - Diphenyl - p - phenylenediamine
  2. DPPD
  3. Ekaland DPPD
  4. Flexamine G
  5. JZF
  6. Naugard J
  7. Permanax 18
  8. Permanax DPPD
  9. p - Phenylaminodiphenylamine
  10. 4 - Phenylaminodiphenylamine
  11. Stabilizer DPPD
  12. USAF GY - 2


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,485,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster lung 1,800 µg/L MUREAV 241,175,1990
mutation in microorganisms Salmonella typhimurium 10 µg/plate (-enzymatic activation step) PCBRD2 141,407,1984
mutation in mammalian somatic cells hamster lung 30 mg/L SWEHDO 9(Suppl 2),27,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 4,176 mg/kg (6-14 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) NTIS** PB223-160
oral
rat 		lowest published toxic dose: 450 mg/kg (14 day prior to copulation/1-22 day pregnant) Reproductive: Maternal effects: Parturition

Reproductive: Effects on newborn: Stillbirth 		JAFCAU 4,796,1956
oral
rat 		lowest published toxic dose: 2,500 mg/kg (1-22 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) AJANA2 110,29,1962


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
subcutaneous
mouse 		lowest published toxic dose: 1,000 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Tumors 		NTIS** PB223-159


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 300 mg/kg N/R NTIS** AD277-689
oral
mouse 		lethal dose (50 percent kill): 18 gm/kg N/R GTPZAB 10(3),49,1966
oral
rat 		lethal dose (50 percent kill): 2,370 mg/kg N/R 85JCAE -,485,1986


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 182 gm/kg/2 year- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		JTSCDR 7,278,1982
oral
rat 		lowest published toxic dose: 20,443 mg/kg/3 week- continuous Blood: Change in clotting factors TXAPA9 46,935,1982


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80282;
Number of Industries 5;
Total Number of Facilities 315;
Number of Occupations 22;
Total Number of Employees Exposed 7,496
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80282;
Number of Industries 4;
Total Number of Facilities 139;
Number of Occupations 6;
Total Number of Employees Exposed 7,680


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as an antioxidant
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8803
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AJANA2 American Journal of Anatomy. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1-192, 1901-91.
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
JAFCAU Journal of Agricultural and Food Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB 57136, West End Stn., Washington, DC 20037) V.1- 1953-
JTSCDR Journal of Toxicological Sciences. (Japanese Soc. of Toxicological Sciences, 4th Floor, Gakkai Center Bldg., 4-16, Yayoi 2-chome, Bunkyo-ku, Tokyo 113, Japan) V.1- 1976-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCBRD2 Progress in Clinical and Biological Research. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.1- 1975-
SWEHDO Scandinavian Journal of Work, Environment and Health. (Haartmaninkatu 1, SF-00290 Helsinki, 29, Finland) V.1- 1975-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used as an antioxidant

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector
   Primary Irritant

ALT CAS #: 66746-42-7
ALT CAS #: 72711-53-6
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