The Registry of Toxic Effects of Chemical Substances

p - Phenylenediamine, dihydrochloride

RTECS #: ST0350000

CAS #: 624-18-0

UPDATE: April 1999 MW: 181.08 MF: C6H8N2•2ClH


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. p - Aminoaniline dihydrochloride
  2. 4 - Aminoaniline dihydrochloride
  3. p - Benzenediamine dihydrochloride
  4. 1,4 - Benzenediamine dihydrochloride
  5. C.I. 76061
  6. C.I. Oxidation Base 10A
  7. p - Diaminobenzene dihydrochloride
  8. 1,4 - Diaminobenzene dihydrochloride
  9. Durafur Black RC
  10. Fourrine 64
  1. Fourrine DS
  2. NCI - C03930
  3. Oxidation Base 10A
  4. p - PD HCl
  5. p - Pda HCl
  6. Pelagol CD
  7. Pelagol Grey CD
  8. 1,4 - Phenylenediamine dihydrochloride
  9. p - Phenylenediamine hydrochloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 333 µg/plate (+enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in microorganisms mouse lymphocyte 31,300 µg/L (+enzymatic activation step) EMMUEG 12(Suppl 13),103,1988
mutation in microorganisms Salmonella typhimurium 33,300 ng/plate (-enzymatic activation step) ENMUDM 7(Suppl 5),1,1985
mutation in mammalian somatic cells human lymphocyte 20 mg/L MUREAV 196,61,1988
mutation in mammalian somatic cells mouse lymphocyte 1,250 µg/L EMMUEG 12(Suppl 13),103,1988
specific locus test oral
Drosophila melanogaster 		500 µmol/L MUREAV 341,161,1995


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 316 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
oral
rat 		lethal dose (50 percent kill): 147 mg/kg N/R NCILB* NCI-E-C-72-3252,1973
subcutaneous
dog 		lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
frog 		lowest published lethal dose: 10 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
mouse 		lowest published lethal dose: 50 mg/kg N/R XPHBAO 271,42,1941
subcutaneous
rabbit 		lowest published lethal dose: 20 mg/kg N/R XPHBAO 271,42,1941


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 16,125,1978


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: Carcinogenicity-mouse/rat
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as an analytical reagent in the testing of blood, HYDROGEN SULFIDE, milk
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Bioassay (feed);no evidence:mouse,rat NCITR* NCI-TR-174,1979


REFERENCES:

CODEN
REFERENCE
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NCILB* Progress Report for Contract No. NIH-NCI-E-C-72-3252, Submitted to the National Cancer Institute by Litton Bionetics, Inc. (Bethesda, MD)
NCITR* National Cancer Institute Carcinogenesis Technical Report Series. (Bethesda, MD) No.0-205. For publisher information, see NTPTR*.
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC)

Used as an analytical reagent in the testing of blood, HYDROGEN SULFIDE, milk

RTECS Compound Description:
   Tumorigen
   Mutagen

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