The Registry of Toxic Effects of Chemical Substances

Phosphine, triphenyl -

RTECS #: SZ3500000

CAS #: 603-35-0

UPDATE: October 1997 MW: 262.30 MF: C18H15P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. PP 360
  2. Trifenylfosfin (Czech)
  3. Triphenylphosphane
  1. Triphenylphosphide
  2. Triphenylphosphine
  3. Triphenylphosphorus


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		500 mg/24 hour mild 85JCAE -,1114,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,1114,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 1,135 ppm/4 hour Eye: Lacrimation

Lung, Thorax, or Respiration: Dyspnea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		AIHAM* -,-,1969
intramuscular
rat 		lethal dose (50 percent kill): 1,500 mg/kg Behavioral: Convulsions or effect on seizure threshold EPASR* 8EHQ-0384-0014
oral
chicken 		lowest published lethal dose: 9 gm/kg Behavioral: Convulsions or effect on seizure threshold EPASR* 8EHQ-0384-0014
oral
dog 		lethal dose (50 percent kill): >500 mg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea

Gastrointestinal: Changes in structure or function of salivary glands 		NTIS** OTS0570648
oral
mouse 		lethal dose (50 percent kill): 1 gm/kg Behavioral: Convulsions or effect on seizure threshold EPASR* 8EHQ-0384-0014
oral
rat 		lethal dose (50 percent kill): 700 mg/kg Behavioral: Convulsions or effect on seizure threshold EPASR* 8EHQ-0384-0014
subcutaneous
mouse 		lethal dose (50 percent kill): 3 gm/kg Behavioral: Convulsions or effect on seizure threshold EPASR* 8EHQ-0384-0014
skin
rabbit 		lethal dose (50 percent kill): >5 gm/kg N/R TXAPA9 28,313,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
dog 		lowest published toxic concentration: 94,500 µg/m3/6 hour/4 week- intermittent Behavioral: Change in motor activity (specific assay) NTIS** OTS0570648
oral
dog 		lowest published toxic dose: 950 mg/kg/14 day- intermittent Spinal Cord: Other degenerative changes

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		NTIS** OTS0570648
oral
dog 		lowest published toxic dose: 525 mg/kg/21 day- intermittent Spinal Cord: Demyelination

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		NTIS** OTS0570648


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4096;
Number of Industries 13;
Total Number of Facilities 268;
Number of Occupations 18;
Total Number of Employees Exposed 14,258;
Total Number of Female Employees Exposed 1,373


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAM* Annual Meeting of American Industrial Hygiene Association. (Akron, OH) For publisher information, see AIHAAP.
EPASR* United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. (U.S. Environmental Protection Agency, 401 M St., SW, Washington, DC 20460) History unknown.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

RTECS Compound Description:
   Primary Irritant

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