The Registry of Toxic Effects of Chemical Substances

Phosphonothioic acid, phenyl - , O - ethyl O - (p - nitrophenyl) ester

RTECS #: TB1925000

CAS #: 2104-64-5

UPDATE: November 2004 MW: 323.32 MF: C14H14NO4PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. O - Aethyl - O - (4 - nitro - phenyl) - phenyl - monothiophosphonat (German)
  2. Benzenephosphonic acid, thiono - , ethyl - p - nitrophenyl ester
  3. ENT 17,798
  4. EPN
  5. EPN (ACGIH:OSHA)
  6. EPN 300
  7. Ethoxy - 4 - nitrophenoxyphenylphosphine sulfide
  8. O - Ethyl - O - p - nitrofenylester kyseliny fenylthiofosfonove (Czech)
  9. O - Ethyl - O - ( (4 - nitro - fenyl) - fenyl) - monothiofosfonaat (Dutch)
  10. Ethyl p - nitrophenyl benzenethionophosphonate
  11. O - Ethyl O - (4 - nitrophenyl) benzenethionophosphonate
  12. Ethyl p - nitrophenyl benzenethiophosphate
  13. Ethyl p - nitrophenyl benzenethiophosphonate
  14. O - Ethyl O - (4 - nitrophenyl) phenylphosphonothioate
  15. O - Ethyl O - p - nitrophenyl phenylphosphonothiolate
  1. Ethyl p - nitrophenyl phenylphosphonothioate
  2. O - Ethyl O - p - nitrophenyl phenylphosphorothioate
  3. Ethyl p - nitrophenyl thionobenzenephosphate
  4. Ethyl p - nitrophenyl thionobenzenephosphonate
  5. O - Ethyl phenyl p - nitrophenyl thiophosphonate
  6. O - Etil - O - ( (4 - nitro - fenil) - fenil) - monotiofosfonato (Italian)
  7. IN - 9663 - 90
  8. O - (4 - Nitrophenyl) O - ethyl phenyl thiophosphonate
  9. OMS 219
  10. Phenol, p - nitro - , O - ester with O - ethyl phenyl phosphonothioate
  11. Phenylphosphonothioate, O - ethyl - O - p - nitrophenyl -
  12. Phenylphosphonothioic acid O - ethyl O - p - nitrophenyl ester
  13. Phenylthiophosphonate de O - ethyle et O - 4 - nitrophenyle (French)
  14. Santox
  15. PIN


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		100 µL moderate NTIS** OTS0540535
skin
rabbit 		500 µL moderate NTIS** OTS0540536


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 132 mg/kg (6-16 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) JPFCD2 20,373,1985


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 106 mg/m3/1 hour Peripheral Nerve and Sensation: Fasciculations

Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Dyspnea 		NTIS** OTS0570820
intraperitoneal
chicken 		lethal dose (50 percent kill): 17 mg/kg N/R BECTA6 18,534,1977
intraperitoneal
dog 		lowest published lethal dose: 35 mg/kg N/R JPETAB 112,29,1954
intraperitoneal
guinea pig 		lethal dose (10 percent kill): 14 mg/kg N/R TXAPA9 8,259,1966
intraperitoneal
mouse 		lethal dose (50 percent kill): 8,400 µg/kg N/R IJBBBQ 15,336,1978
intraperitoneal
rat 		lethal dose (50 percent kill): 7,200 µg/kg N/R APCRAW 4,117,1961
intraperitoneal
rabbit 		lowest published lethal dose: 20 mg/kg N/R JPETAB 112,29,1954
oral
wild bird 		lethal dose (50 percent kill): 2,370 µg/kg N/R ASTTA8 (680),157,1979
oral
chicken 		lethal dose (50 percent kill): 5 mg/kg N/R JPFCD2 17,611,1982
oral
duck 		lethal dose (50 percent kill): 3 mg/kg N/R TXAPA9 20,57,1971
oral
dog 		lethal dose (50 percent kill): 20 mg/kg N/R PCOC** -,478,1966
oral
mouse 		lethal dose (50 percent kill): 12,200 µg/kg N/R ABCHA6 26,257,1962
oral
pigeon 		lethal dose (50 percent kill): 4,210 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 5 mg/kg N/R TXAPA9 20,57,1971
oral
rat 		lethal dose (50 percent kill): 7 mg/kg N/R JPETAB 112,29,1954
subcutaneous
mouse 		lethal dose (50 percent kill): 22,900 µg/kg N/R TOIZAG 25,635,1978
skin
cat 		lethal dose (50 percent kill): 45 mg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Ataxia 		TOLED5 1000(Sp Iss 1),141,1980
skin
duck 		lethal dose (50 percent kill): 400 mg/kg N/R TXAPA9 47,451,1979
skin
mouse 		lethal dose (50 percent kill): 348 mg/kg N/R ABCHA6 26,257,1962
skin
rat 		lethal dose (50 percent kill): 25 mg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rabbit 		lethal dose (50 percent kill): 30 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Other changes 		AFDOAQ 16,3,1952
unreported route
rat 		lethal dose (50 percent kill): 7 mg/kg N/R JPETAB 128,289,1960


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
chicken 		lowest published toxic dose: 90 mg/kg/90 day- intermittent Behavioral: Ataxia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 45,685,1978
oral
dog 		lowest published toxic dose: 35 mg/kg/4 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPETAB 121,96,1957
oral
rat 		lowest published toxic dose: 84 mg/kg/8 week- continuous Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JPETAB 121,96,1957
oral
rat 		lowest published toxic dose: 2,700 mg/kg/30 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		JPETAB 112,29,1954
skin
cat 		lowest published toxic dose: 180 mg/kg/90 day- intermittent Spinal Cord: Demyelination

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TXAPA9 68,54,1983
skin
chicken 		lowest published toxic dose: 90 mg/kg/90 day- intermittent Behavioral: Ataxia JTEHD6 16,85,1985


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 mg/m3 (skin) ( intermittent) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
AQMOAC #73-19,1973
TOXICOLOGY REVIEW
TXAPA9 47,451,1979


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,116,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,99,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.5 mg/m3 (skin) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.1 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

Not Classifiable as a Human Carcinogen
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
Not Classifiable as a Human Carcinogen


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO EPN-air 10 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: EPN, 5012


REFERENCES:

CODEN
REFERENCE
ABCHA6 Agricultural and Biological Chemistry. (Maruzen Co. Ltd., POB 5050, Tokyo International, Tokyo 100-31, Japan) V.25- 1961-
AFDOAQ Quarterly Bulletin--Association of Food and Drug Officials of the United States. (Denver, CO) V.3-38, 1939-74.
APCRAW Advances in Pest Control Research. (New York, NY) V.1-18, 1957-68.
AQMOAC Air Quality Monographs. (Washington, DC) No.69-1 - No.75-25, 1969-75(?). Discontinued.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BECTA6 Bulletin of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1966-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJBBBQ Indian Journal of Biochemistry and Biophysics. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.8- 1971-
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
JPFCD2 Journal of Environmental Science and Health, Part B: Pesticides, Food Contaminants, and Agricultural Wastes. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.B11- 1976-
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
TOIZAG Toho Igakkai Zasshi. Journal of Medical Society of Toho University. (Toho Daigaku Igakkai, 21-16, Omori-nishi, 5-chome, Ota-ku, Tokyo 143, Japan) V.1- 1954-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in preparation of emulsifiable, granular or wettable powder insecticides for cotton

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Reproductive Effector
   Primary Irritant

ALT CAS #: 65580-81-6
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