The Registry of Toxic Effects of Chemical Substances

Phosphoramidothioic acid, N - acetyl - , O,S - dimethyl ester

RTECS #: TB4760000

CAS #: 30560-19-1

UPDATE: May 2005 MW: 183.18 MF: C4H10NO3PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 75 SP
  2. Acephat (German)
  3. Acephate
  4. Acetamidophos
  5. Acetylphosphoramidothioic acid O,S - dimethyl ester
  6. Chevron RE 12,420
  7. ENT 27822
  8. N - (Methoxy (methylthio) phosphinoyl) acetamide
  9. O,S - dimethyl acetyl phosphoramidothioate
  1. O,S - Dimethylacetylphosphoroamidothioate
  2. Orthene
  3. Orthene - 755
  4. Ortho 124120
  5. Ortho 12420
  6. Ortran
  7. Ortril
  8. RE 12420


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intraperitoneal
mouse 		150 mg/kg MUREAV 223,287,1989
dominant lethal test intraperitoneal
mouse 		250 mg/kg/5 day- continuous MUREAV 223,287,1989
DNA damage oral
mouse 		12.25 mg/kg MUREAV 516,139,2002
unscheduled DNA synthesis human fibroblast 1 gm/L NTIS** PB80-133226
mutation in microorganisms Escherichia coli 5 mg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 3 mg/plate (+enzymatic activation step) NTIS** PB80-133226
mutation in microorganisms Salmonella typhimurium 50 mg/plate (-enzymatic activation step) MUREAV 116,185,1983
mutation in microorganisms Saccharomyes cerevisiae 3 pph (+enzymatic activation step) NTIS** PB84-138973
micronucleus test intraperitoneal
mouse 		500 mg/kg/24 hour MUREAV 223,287,1989
gene conversion and mitotic recombination Saccharomyes cerevisiae 50,000 ppm NTIS** PB80-133226
mutation in mammalian somatic cells mouse lymphocyte 1 gm/L NTIS** PB84-138973
sister chromatid exchange hamster ovary 2 gm/L NTIS** PB84-138973
sperm morphology intraperitoneal
mouse 		150 mg/kg/5 day- continuous MUREAV 223,287,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 150 mg/kg (5 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) MUREAV 223,287,1989
intraperitoneal
mouse 		lowest published toxic dose: 200 mg/kg (5 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) MUREAV 223,287,1989
oral
mouse 		lowest published toxic dose: 140 mg/kg (6-15 day pregnant) Reproductive: Other effects on female REPTED 14,241,2000
oral
mouse 		lowest published toxic dose: 280 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		REPTED 14,241,2000
oral
mouse 		lowest published toxic dose: 560 mg/kg (20 day male) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 14,457,2000


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lowest published lethal concentration: 2,200 mg/m3/5 hour N/R TXAPA9 45,232,1978
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Endocrine: Other changes

Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		JJATDK 22,279,2002
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Behavioral: Tremor

Blood: Changes in leukocyte (WBC) count

Immunological Including Allergic: Decrease in cellular immune response 		JJATDK 22,279,2002
intraperitoneal
rat 		lowest published toxic dose: 100 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase JAPTO* 22,279,2002
intraperitoneal
rat 		lowest published toxic dose: 500 mg/kg Blood: Changes in leukocyte (WBC) count JAPTO* 22,279,2002
oral
domestic bird 		lethal dose (50 percent kill): 106 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		AECTCV 10,185,1981
oral
wild bird 		lethal dose (50 percent kill): 140 mg/kg N/R PEMNDP 9,4,1991
oral
chicken 		lethal dose (50 percent kill): 800 mg/kg N/R NRTXDN 11,483,1990
oral
duck 		lethal dose (50 percent kill): 350 mg/kg N/R 28ZEAL 5,4,1976
oral
dog 		lowest published lethal dose: 681 mg/kg N/R GUCHAZ 6,1,1973
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 321 mg/kg N/R AECTCV 13,483,1984
oral
mouse 		lethal dose (50 percent kill): 233 mg/kg N/R CHYCDW 14,226,1980
oral
rat 		lethal dose (50 percent kill): 700 mg/kg N/R USXXAM #3716600
skin
rat 		lethal dose (50 percent kill): >2,500 mg/kg N/R FAATDF 7,299,1986
skin
rabbit 		lethal dose (50 percent kill): 2 gm/kg N/R 85DPAN -,-,1971/1976
unreported route
chicken 		lethal dose (50 percent kill): 568 mg/kg N/R DEVEAA 28,231,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published toxic dose: 375 mg/kg/3 day- intermittent Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		FCTOD7 43,173,2005
intraperitoneal
mouse 		lowest published toxic dose: 750 mg/kg/3 day- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field FCTOD7 43,173,2005
oral
mouse 		lowest published toxic dose: 15 mg/kg/5 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TOLED5 24,65,1985
oral
mouse 		lowest published toxic dose: 13,500 mg/kg/90 day- intermittent Liver: Other changes HOEKAN 22,48,1922
oral
mouse 		lowest published toxic dose: 280 mg/kg/10 day- intermittent Autonomic Nervous System: Parasympatholytic

Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 14,241,2000
oral
mouse 		lowest published toxic dose: 140 mg/kg/10 day- intermittent Brain and Coverings: Changes in brain weight REPTED 14,241,2000
oral
mouse 		lowest published toxic dose: 560 mg/kg/20 day- intermittent Behavioral: Tremor

Gastrointestinal: Changes in structure or function of salivary glands

Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles) 		REPTED 14,457,2000
oral
mouse 		lowest published toxic dose: 280 mg/kg/20 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females)

Related to Chronic Data: Changes in testicular weight 		REPTED 14,457,2000
oral
mouse 		lowest published toxic dose: 140 mg/kg/20 day- intermittent Behavioral: Muscle weakness REPTED 14,457,2000
oral
mouse 		lowest published toxic dose: 110,250 mg/kg/105 week- continuous Liver: Tumors HBPTO* 1,814,2001
oral
rat 		lowest published toxic dose: 14,580 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		CHYCDW 14,226,1980
oral
rat 		lowest published toxic dose: 1,050 mg/kg/15 week- intermittent Brain and Coverings: Other degenerative changes

Autonomic Nervous System: Sympathomimetic

Biochemical: Metabolism (intermediary): Amino acids (including renal excretion) 		ENVRAL 43,342,1987
oral
rat 		lowest published toxic dose: 33,600 mg/kg/8 week- intermittent Liver: Other changes

Biochemical: Metabolism (intermediary): Other proteins 		IJEBA6 21,684,1983
oral
rat 		lowest published toxic dose: 712 mg/kg/4 day- intermittent Brain and Coverings: Other degenerative changes TOXID9 72,74,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
TOLED5 127,29,2002


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,82,1998


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: T0473;
Number of Industries 2;
Total Number of Facilities 196;
Number of Occupations 1;
Total Number of Employees Exposed 770;
Total Number of Female Employees Exposed 378


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Negative: N crassa-aneuploidy; Histidine reversion-Ames test
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
Used as contact and systemic insecticide
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZEAL "Pesticide Index," Frear, E.H., ed., State College, PA, College Science Pub., 1969
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973-
CHYCDW Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) Beginning history not known.
DEVEAA Defense des Vegetaux. (Federation Nationale des Groupements de Protection des Cultures, 149, rue de Bercy, 75595 Paris Cedex, 12, France) V.1- 1947-
ENVRAL Environmental Research. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1967-
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GUCHAZ Guide to the Chemicals Used in Crop Protection. (Information Canada, 171 Slater St., Ottawa, Ont., Canada)
HBPTO* Handbook of pesticide toxicology. Robert Krieger ed, Academic press, 2001
HOEKAN Hokkaidoritsu Eisei Kenkyushoho. Report of the Hokkaido Institute of Public Health. (Nishi- 12-chome, Kita-19-jo, Kita-ku, Sapporo 060, Japan) No.1- 1951-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JAPTO* Journal of Applied Toxicology (John Wiley & Sons, Ltd., Oldlands Way Bognor Regis West Sussex, PO22 9SA England) V.1- 1981-
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NRTXDN Neurotoxicology. (Intox Press, Inc., POB 34075, Little Rock, AR 72203) V.1- 1979-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
REPTED Reproductive Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1987-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TOXID9 Toxicologist. (Soc. of Toxicology, Inc., 475 Wolf Ledge Parkway, Akron, OH 44311) V.1- 1981-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as contact and systemic insecticide

RTECS Compound Description:
   Agricultural Chemical
   Drug
   Mutagen
   Reproductive Effector

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