The Registry of Toxic Effects of Chemical Substances

Phosphoric acid, 2 - chloro - 1 - (2,4 - dichlorophenyl) vinyl diethyl ester

RTECS #: TB8750000

CAS #: 470-90-6

UPDATE: August 2004 MW: 359.58 MF: C12H14Cl3O4P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Apachlor
  2. Benzyl alcohol, 2,4 - dichloro - alpha - (chloromethylene) - , diethyl phosphate
  3. Birlane
  4. Birlane 10G
  5. CGA 26351
  6. O - 2 - Chlor - 1 - (2,4 - dichlor - phenyl) - vinyl - O,O - diaethylphosphat (German)
  7. O - 2 - Chloor - 1 - (2,4 - dichloor - fenyl) - vinyl - O,O - diethylfosfaat (Dutch)
  8. Chlorfehwinfos (Polish)
  9. Chlorfenvinfos
  10. Chlorfenvinphos
  11. 2 - Chloro - 1 - (2,4 - dichlorophenyl) vinyl diethyl phosphate
  12. beta - 2 - Chloro - 1 - (2',4' - dichlorophenyl) vinyl diethylphosphate
  13. Chlorphenvinfos
  14. Chlorphenvinphos
  15. O - 2 - Cloro - 1 - (2,4 - dicloro - fenil) - vinil - O,O - dietilfosfato (Italian)
  16. Compound 4072
  17. CVP (pesticide)
  18. Dermaton
  19. O,O - Diaethyl - O - 1 - (4,5 - dichlorphenyl) - 2 - chlor - vinyl - phosphat (German)
  1. O,O - Diethyl O - (2 - chloro - 1 - (2',4' - dichlorophenyl) vinyl) phosphate
  2. Diethyl 1 - (2,4 - dichlorophenyl) - 2 - chlorovinyl phosphate
  3. O,O - Dwuetylo - O - 1 - (2,4 - dwuchlorofenylo) - 2 - chlorowinylofosforan (Polish)
  4. Enolofos
  5. ENT 24969
  6. GC 4072
  7. OMS 1328
  8. Phosphate de O,O - diethyle et de O - 2 - chloro - 1 - (2,4 - dichlorophenyl) vinyle (French)
  9. Phosphoric acid, 2 - chloro - 1 - (2,4 - dichlorophenyl) ethenyl diethyl ester (9CI)
  10. C8949
  11. Haptasol
  12. Steladone
  13. Sapecron
  14. SD 7859
  15. Supona
  16. Tarene
  17. Unitox
  18. Vinyphate
  19. Zaprawa enolofos


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 500 µg/plate (+enzymatic activation step) MUREAV 116,185,1983


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 50 mg/m3/4 hour N/R PEMNDP 9,142,1991
intraperitoneal
chicken 		lethal dose (50 percent kill): 23,100 µg/kg N/R VETRAX 77,1140,1965
intraperitoneal
mouse 		lethal dose (50 percent kill): 87 mg/kg N/R JPPMAB 19,612,1967
intraperitoneal
rat 		lethal dose (50 percent kill): 8,500 µg/kg N/R VETRAX 77,1140,1965
intraperitoneal
rat 		lowest published toxic dose: 0.5 mg/kg Behavioral: Change in motor activity (specific assay) ANBEX* 62,75,2002
intravenous
dog 		lethal dose (50 percent kill): 51 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 17,323,1970
intravenous
mouse 		lethal dose (50 percent kill): 87 mg/kg N/R JPPMAB 19,612,1967
intravenous
rat 		lethal dose (50 percent kill): 6,600 µg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 17,323,1970
oral
wild bird 		lethal dose (50 percent kill): 13 mg/kg N/R JTCEEM 6(3),175,1986
oral
chicken 		lethal dose (50 percent kill): 29,100 µg/kg Peripheral Nerve and Sensation: Flaccid paralysis without anesthesia (usually neuromuscular blockage)

Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold 		TXAPA9 11,49,1967
oral
cattle 		lethal dose (50 percent kill): 20 mg/kg N/R VETRAX 77,1140,1965
oral
dog 		lethal dose (50 percent kill): 1,200 mg/kg N/R 85GYAV -,18,1971
oral
domestic animal 		lethal dose (50 percent kill): 71,250 µg/kg N/R VETRAX 77,1140,1965
oral
guinea pig 		lethal dose (50 percent kill): 125 mg/kg N/R BCPCA6 16,949,1967
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 10 mg/kg N/R HPBIA9 21,53,1975
oral
mouse 		lethal dose (50 percent kill): 65 mg/kg N/R OYYAA2 1,78,1967
oral
pigeon 		lethal dose (50 percent kill): 13,300 µg/kg N/R ASTTA8 (680),157,1979
oral
quail 		lethal dose (50 percent kill): 148 mg/kg Peripheral Nerve and Sensation: Fasciculations

Gastrointestinal: Hypermotility, diarrhea 		PSSCBG 2,148,1971
oral
rat 		lethal dose (50 percent kill): 10 mg/kg N/R FMCHA2 -,C69,1991
oral
rabbit 		lethal dose (50 percent kill): 300 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 17,323,1970
subcutaneous
mouse 		lethal dose (50 percent kill): 339 mg/kg N/R JPPMAB 19,612,1967
subcutaneous
rat 		lethal dose (50 percent kill): 7 mg/kg N/R APYPAY 32,507,1981
skin
human 		lowest published toxic dose: 10 mg/kg Blood: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		IMSUAI 38,25,1969
skin
mouse 		lethal dose (50 percent kill): 336 mg/kg N/R OYYAA2 1,78,1967
skin
rat 		lethal dose (50 percent kill): 26,400 µg/kg N/R APYPAY 32,507,1981
skin
rabbit 		lethal dose (50 percent kill): 400 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Gastrointestinal: Hypermotility, diarrhea 		TXAPA9 17,323,1970


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 2 mg/kg/3 week- intermittent Brain and Coverings: Changes in surface EEG

Brain and Coverings: Recordings from specific areas of CNS 		TOLED5 135,S49,2002
intraperitoneal
rat 		lowest published toxic dose: 2.5 mg/kg/5 day- intermittent Behavioral: Change in motor activity (specific assay)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		ANBEX* 62,75,2002
oral
dog 		lowest published toxic dose: 2,100 µg/kg/12 week- continuous Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase TXAPA9 17,323,1970
oral
mouse 		lowest published toxic dose: 697 mg/kg/7 day- continuous Brain and Coverings: Other degenerative changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases 		PCBPBS 18,49,1982
oral
rat 		lowest published toxic dose: 420 mg/kg/12 week- continuous Endocrine: Changes in spleen weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		TXAPA9 17,323,1970
oral
rat 		lowest published toxic dose: 49 mg/kg/35 week- intermittent Cardiac: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Other changes 		BCTKAG 10,243,1977
oral
rat 		lowest published toxic dose: 182 mg/kg/26 week- intermittent Blood: Changes in leukocyte (WBC) count BCTKAG 9,267,1976
subcutaneous
rat 		lowest published toxic dose: 50,400 mg/kg/28 day- intermittent Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		APYPAY 31,575,1980
subcutaneous
rat 		lowest published toxic dose: 14 mg/kg/17 week- intermittent Kidney, Ureter, and Bladder: Changes in tubules (including acute renal failure, acute tubular necrosis)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		APYPAY 32,507,1981


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
RREVAH 46,1,1973
TOXICOLOGY REVIEW
CNDQA8 10(3),43,1975
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,167,1998
Occupational Exposure Limit - POLAND MAC(time-weighted average) 0.01 mg/m3, MAC(short term exposure limit) 0.1 mg/m3, JAN1999


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/98/101116/AS)


REFERENCES:

CODEN
REFERENCE
85GYAV "Pflanzenschutz-und Schaedlingsbekaempfungsmittel: Abriss einer Toxikologie und Therapie von Vergiftungen," 2nd ed., Klimmer, O.R., Hattingen, Fed. Rep. Ger., Hundt-Verlag, 1971
ANBEX* Acta neurobiologiae experimentalis (Warszawa : Nencki Institute of Experimental Biology) V. 30- 1970
APYPAY Acta Physiologica Polonica. (Karger-Libri, POB CH-4009, Warszawa, Switzerland) V.1-41, 1950-90.
ASTTA8 ASTM Special Technical Publication. (American Soc. for Testing Materials, 1916 Race St., Philadelphia, PA 19103) No.1- 1911-
BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971-
CNDQA8 Cahiers de Nutrition et de Dietetique. (Editions Meteore, 42, rue du Louvre, 75001 Paris, France) V.1- 1966-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
HPBIA9 Herba Polonica. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.11- 1965-
IMSUAI Industrial Medicine and Surgery. (Northbrook, IL) V.18-42, 1949-73. For publisher information, see IOHSA5.
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949-
JTCEEM Journal de Toxicologie Clinique et Experimentale. (SPPIF, B.P.22, F-41353 Vineuil, France) V.5- 1985-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967-
PCBPBS Pesticide Biochemistry and Physiology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1971-
PEMNDP Pesticide Manual. (The British Crop Protection Council, 20 Bridport Rd., Thornton Heath CR4 7QG, UK) V.1- 1968-
PSSCBG Pesticide Science. (Blackwell Scientific Pub. Ltd., POB 88, Oxford, UK) V.1- 1970-
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VETRAX Veterinary Record. (7 Mansfield St., London W1M 0AT, UK) V.1- 1888-

Used as a soil insecticide for root maggots, rootworms and cutworms

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Human Data

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