The Registry of Toxic Effects of Chemical Substances

Phosphorochloridothioic acid, O,O - diethyl ester

RTECS #: TD1780000

CAS #: 2524-04-1

UPDATE: July 2000 MW: 188.62 MF: C4H10ClO2PS


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Diethylchlorothiophosphate
  2. Diethylchlorthiofosfat (Czech)
  3. O,O - Diethylphosphorochloridothioate
  1. Ethyl PCT
  2. Phosphonothioic acid, chloro - , O,O - diethyl ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 725 mg/m3/2 hour N/R 85GMAT -,51,1982
inhalation
rat 		lethal concentration (50 percent kill): 20 ppm/4 hour N/R 85JCAE -,1172,1986
oral
guinea pig 		lethal dose (50 percent kill): 810 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage 		HYSAAV 33(10-12),334,1968
oral
mouse 		lethal dose (50 percent kill): 800 mg/kg N/R 85GMAT -,51,1982
oral
rat 		lethal dose (50 percent kill): 1,340 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage 		HYSAAV 33(10-12),334,1968
oral
rabbit 		lethal dose (50 percent kill): 900 mg/kg Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Blood: Hemorrhage 		HYSAAV 33(10-12),334,1968
skin
rabbit 		lowest published lethal dose: 200 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Other changes

Blood: Other changes 		NTIS** OTS0536769
unreported route
mouse 		lethal dose (50 percent kill): 750 mg/kg N/R GISAAA 56(5),6,1991


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 1 mg/m3/24 hour/17 week- continuous Brain and Coverings: Recordings from specific areas of CNS

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 56(5),6,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X4068;
Number of Industries 2;
Total Number of Facilities 30;
Number of Occupations 4;
Total Number of Employees Exposed 1,088;
Total Number of Female Employees Exposed 187


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as intermediate for synthesis of agricultural chemicals and other products
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

Used as intermediate for synthesis of agricultural chemicals and other products

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