The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, O,O - diethyl S - (ethylthio) methyl ester

RTECS #: TD9450000

CAS #: 298-02-2

UPDATE: November 2004 MW: 260.39 MF: C7H17O2PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. AC 3911
  2. Agrimet
  3. American cyanamid 3,911
  4. Dithiophosphate de O,O - diethyle et d'ethylthiomethyle (French)
  5. EI3911
  6. ENT 24,042
  7. Experimental insecticide 3911
  8. Foraat (Dutch)
  9. Geomet
  10. Granutox
  11. L 11/6
  12. Methanethiol, (ethylthio) - , S - ester with O,O - diethyl phosphorodithioate
  13. O,O - Diaethyl - S - (aethylthio - methyl) - dithiophosphat (German)
  14. O,O - Diethyl S - (ethylthio) methyl phosphorodithioate
  15. O,O - Diethyl S - ethylmercaptomethyl dithiophosphonate
  16. O,O - Diethyl S - ethylthiomethyl dithiophosphonate
  1. O,O - Diethyl S - ethylthiomethyl thiothionophosphate
  2. O,O - Diethyl ethylthiomethyl phosphorodithioate
  3. O,O - Diethyl - S - (ethylthio - methyl) - dithiofosfaat (Dutch)
  4. O,O - Dietil - S - (etiltio - metil) - ditiofosfato (Italian)
  5. Phorat (German)
  6. Phorate
  7. Phorate (ACGIH)
  8. Phorate - 10G
  9. RCRA waste number P094
  10. Rampart
  11. Thimenox
  12. Thimet
  13. Timet
  14. VUAgT 182
  15. Vegfru
  16. Vergfru foratox


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
human 		1%/48 hour CODEDG 17,212,1987


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster ovary 40 mg/L MUREAV 188,241,1987
cytogenetic analysis intraperitoneal
rat 		180 µg/kg NULSAK 33,14,1990
micronucleus test intraperitoneal
mouse 		750 µg/kg MUREAV 155,131,1985
micronucleus test intraperitoneal
rat 		750 µg/kg/5 day- continuous MUREAV 188,45,1987
sister chromatid exchange hamster ovary 40 mg/L MUREAV 188,311,1987
sister chromatid exchange human lymphocyte 2 mg/L MUREAV 102,89,1982
sister chromatid exchange rat other cell types 50 mg/L MUREAV 188,311,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
gerbil 		lowest published toxic dose: 2,500 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		IJEBA6 18,1001,1980


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 11 mg/m3/1 hour N/R NTIS** PB277-077
intraperitoneal
gerbil 		lethal dose (50 percent kill): 1,866 µg/kg Behavioral: Convulsions or effect on seizure threshold

Lung, Thorax, or Respiration: Bronchiolar constriction, including asthma

Gastrointestinal: Hypermotility, diarrhea 		JAMPA2 28,234,1981
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,100 µg/kg N/R AEPPAE 236,202,1959
intraperitoneal
rat 		lethal dose (50 percent kill): 1,980 µg/kg N/R AEPPAE 236,202,1959
intravenous
rat 		lethal dose (50 percent kill): 1,200 µg/kg N/R NTIS** PB277-077
oral
wild bird 		lethal dose (50 percent kill): 1 mg/kg N/R TXAPA9 21,315,1972
oral
duck 		lethal dose (50 percent kill): 600 µg/kg N/R DOEAAH 35,25,1979
oral
mouse 		lethal dose (50 percent kill): 2,250 µg/kg N/R AEPPAE 236,202,1959
oral
quail 		lethal dose (50 percent kill): 7 mg/kg Behavioral: Convulsions or effect on seizure threshold

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		EESADV 8,551,1984
oral
rat 		lethal dose (50 percent kill): 1 mg/kg N/R DOEAAH 35,25,1979
skin
duck 		lethal dose (50 percent kill): 203 mg/kg N/R TXAPA9 47,451,1979
skin
guinea pig 		lethal dose (50 percent kill): 20 mg/kg N/R PCOC** -,895,1966
skin
rat 		lethal dose (50 percent kill): 2,500 µg/kg Behavioral: Tremor

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		TXAPA9 2,88,1960
skin
rat 		lethal dose (50 percent kill): 2.5 mg/kg N/R USXXAM #5643590
skin
rabbit 		lethal dose (50 percent kill): 3.1 mg/kg N/R USXXAM #5643590


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin) DTLVS* TLV/BEI,2002
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin);short term exposure limit 0.2 mg/m3 (sk DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value short term exposure limit 0.2 mg/m3 (skin) DTLVS* TLV/BEI,2002
TOXICOLOGY REVIEW
RREVAH 46,1,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Supported RBREV* -,142,1998
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 0.05 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 mg/m3, Skin, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, SEP2000
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

short term exposure limit 0.2 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
short term exposure limit 0.2 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHORATE-air 10 hour time-weighted average 0.05 mg/m3;
short term exposure limit 0.2 mg/m3 (Sk) 		NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Negative: D melanogaster Sex-linked lethal
EPA GENETOX PROGRAM 1988, Negative: In vitro UDS-human fibroblast; TRP reversion
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-homozygosis
EPA GENETOX PROGRAM 1988, Inconclusive: B subtilis rec assay; E coli polA without S9
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as systemic and contact insecticide and acaracide and as a soil insecticide
On EPA IRIS database
NIOSH Analytical Method, 1994: Organophosphorus pesticides, 5600


REFERENCES:

CODEN
REFERENCE
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
CODEDG Contact Dermatitis. Environmental and Occupational Dermatitis. (Munksgaard International Pub., c/o Publications Expediting Inc., 200 Meacham Ave., Elmont, NY 11003) V.1- 1975-
DOEAAH Down to Earth. (Dow Chemical USA, Agricultural Products Dept., Midland, MI 48640) V.1- 1945-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963-
JAMPA2 Journal of Animal Morphology and Physiology. (Soc. of Animal Morphologists and Physiologists, Dept. of Zoology, Faculty of Science, M.S. Univ. of Baroda, Baroda 2, India) V.1- 1954-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
NULSAK Nucleus (Calcutta). (Dr. A.K. Sharma, Centre of Advanced Studies in Cell and Chromosome Research, Calcutta, 35 Baliygunge Circular Rd., Calcutta 700 019, India) V.1- 1958-
PCOC** Pesticide Chemicals Official Compendium, Association of the American Pesticide Control Officials, Inc., 1966. (Topeka, KS)
RBREV* Status of Pesticides in Registration, Reregistration, and Special Review (Rainbow Report), Special Review and Reregistration Division Office of Pesticide Programs U.S. Environmental Protection Agency, 401 M. Street, S.W., Washington, D.C. 20460, Spring 1998
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231)

Used as systemic and contact insecticide and acaracide and as a soil insecticide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Reproductive Effector
   Hormone
   Primary Irritant

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