The Registry of Toxic Effects of Chemical Substances

Phosphorodithioic acid, S - (2 - (ethylthio) ethyl) O,O - dimethyl ester

RTECS #: TE4375000

CAS #: 640-15-3

UPDATE: July 2000 MW: 246.36 MF: C6H15O2PS3


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. REFERENCES:

SYNONYMS:

  1. BAY 23129
  2. Bayer 23129
  3. Compound M - 81
  4. O,O - Dimethyl - S - (2 - aethylthio - aethyl) - dithio phosphat (German)
  5. O,O - Dimethyl - S - (2 - ethylmercaptoethyl) dithiophosphate
  6. O,O - Dimethyl - S - 2 - ethylmerkaptoethylester kyseliny dithiofosforecne (Czech)
  7. O,O - Dimethyl - S - (2 - ethylthio - ethyl) - dithiofosfaat (Dutch)
  8. O,O - Dimethyl S - (2 - (ethylthio) ethyl) phosphorodithioate
  9. O,O - Dimetil - S - (etiltio - etil) - ditiofosfato (Italian)
  10. Dithiometasystox
  11. Dithiomethon
  12. Dithiometon (French)
  13. Dithiophosphate de O,O - dimethyle et de S - (2 - ethylthio - ethyle) (French)
  14. Ebicid
  15. Ekatin
  1. Ekatin aerosol
  2. Ekatine - 25
  3. Ekatin ULV
  4. Ethanethiol, 2 - (ethylthio) - , S - ester with O,O - dimethyl phosphorodithioate
  5. 2 - Ethylthioethyl O,O - dimethyl phosphorodithioate
  6. S - (2 - (Ethylthio) ethyl) O,O - dimethylphosphorodithionate
  7. S - (2 - (Ethylthio) ethyl) dimethyl phosphorothiolothionate
  8. Luxistelm
  9. M 81
  10. Intrathion
  11. Intration
  12. Phosphorodithioic acid, O,O - dimethyl S - (2 - ethylthio) ethyl ester
  13. SAN 230
  14. Thiometon
  15. Veltin


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		750 µg/24 hour severe 85JCAE -,1176,1986
skin
rabbit 		500 mg/24 hour mild 85JCAE -,1176,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 5 mg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 1 mg/plate (-enzymatic activation step) MUREAV 116,185,1983
micronucleus test intraperitoneal
mouse 		100 mg/kg MUREAV 155,131,1985
micronucleus test intraperitoneal
rat 		75 mg/kg/5 day- continuous MUREAV 188,45,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 20 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 4(9),21,1960
inhalation
rat 		lowest published lethal concentration: 20 mg/m3/4 hour Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 4(9),21,1960
intraperitoneal
mouse 		lethal dose (50 percent kill): 34 mg/kg N/R AEPPAE 236,202,1959
intraperitoneal
rat 		lethal dose (50 percent kill): 30 mg/kg N/R AEPPAE 236,202,1959
intravenous
rat 		lethal dose (50 percent kill): 38,500 µg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		13ZGAF -,206,1962
oral
mouse 		lethal dose (50 percent kill): 37 mg/kg Behavioral: Tremor

Behavioral: Muscle contraction or spasticity

Lung, Thorax, or Respiration: Dyspnea 		GTPZAB 4(9),21,1960
oral
rat 		lethal dose (50 percent kill): 40 mg/kg N/R ARZNAD 5,584,1955
skin
rat 		lethal dose (50 percent kill): 179 mg/kg Eye: Lacrimation

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		13ZGAF -,206,1962
skin
rabbit 		lowest published lethal dose: 100 mg/kg N/R 85GMAT -,57,1982
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 70 mg/kg N/R 30ZDA9 -,368,1971
unreported route
mouse 		lethal dose (50 percent kill): 36 mg/kg N/R GTPZAB 7(5),38,1963


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 442 mg/kg/78 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FATOBP 8,122,1973
oral
rat 		lowest published toxic dose: 305 mg/kg/9 week- intermittent Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field GTPZAB 4(9),21,1960


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
TOXICOLOGY REVIEW
MZUZA8 (8),90,1973


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
13ZGAF "Gigiena i Toksikologiya Novykh Pestitsidov i Klinika Otravlenii, Doklady Vsesoyuznoi Konferentsii, 2nd, 1962," Hygiene and Toxicology of New Pesticides and Clinical Aspects of Poisoning, Medved, L.I., et al., eds., Komiteta Po Izucheniiu i Reglamenta-tsii Indokhimikatov Glavnoi Gosudarstvennoi Sanitarnoi Inspectsii USSR, 1962
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC.
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MZUZA8 Meditsinskii Zhurnal Uzbekistana. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1957-

Used as a systemic insecticide and acaricide

RTECS Compound Description:
   Agricultural Chemical
   Mutagen
   Primary Irritant

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