The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, S - (2 - (ethylthio) ethyl) O,O - dimethyl ester

RTECS #: TG1750000

CAS #: 919-86-8

UPDATE: May 2004 MW: 230.30 MF: C6H15O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. REVIEWS:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. BAY 18436
  2. Bayer 25/154
  3. O,O - Dimethyl - S - (2 - aethylthio - aethyl) - monothiophosphat (German)
  4. O,O - Dimethyl S - (2 - eththioethyl) phosphorothioate
  5. Dimethyl S - (2 - eththioethyl) thiophosphate
  6. O,O - Dimethyl S - ethylmercaptoethyl thiophosphate
  7. O,O - Dimethyl 2 - ethylmercaptoethyl thiophosphate, thiolo isomer
  8. O,O - Dimethyl - S - (2 - ethylthio - ethyl) - monothiofosfaat (Dutch)
  9. O,O - Dimethyl S - (2 - (ethylthio) ethyl) phosphorothioate
  10. O,O - Dimethyl - S - (3 - thia - pentyl) - monothiophosphat (German)
  11. O,O - Dimetil - S - (2 - etiltio - etil) - monotiofosfato (Italian)
  12. S - (2 - (Ethylthio) ethyl) dimethyl phosphorothiolate
  13. S - (2 - (Ethylthio) ethyl) O,O - dimethyl phosphorothioate
  14. S - (2 - (Ethylthio) ethyl) O,O - dimethyl thiophosphate
  15. Phosphorothioic acid, O,O - dimethyl S - (2 - (ethylthio) ethyl) ester
  1. Demeton - S - methyl
  2. Demeton - S - metile (Italian)
  3. Ethanethiol, 2 - (ethylthio) - , S - ester with O,O - dimethyl phosphorothioate
  4. Isometasystox
  5. Metaisoseptox
  6. Metaisosystox
  7. Metasystox forte
  8. Metasystox (I)
  9. Metasystox J
  10. Methyl demeton thioester
  11. Methyl isosystox
  12. Methyl - mercaptofos teolery
  13. Methyl thionodemeton
  14. Thiophosphate de O,O - dimethyle et de S - 2 - ethylthio - ethyle (French)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Escherichia coli 5 mg/plate (-enzymatic activation step) MUREAV 28,405,1975
mutation in microorganisms Salmonella typhimurium 5 mg/plate (+enzymatic activation step) MUREAV 28,405,1975
sex chromosome loss and nondisjunction oral
Drosophila melanogaster 		80 ppm MUREAV 28,405,1975


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lethal concentration (50 percent kill): 500 mg/m3/4 hour N/R 85DPAN -,-,1971/1976
intraperitoneal
guinea pig 		lethal dose (50 percent kill): 12,500 µg/kg N/R TXAPA9 4,621,1962
intraperitoneal
rat 		lethal dose (50 percent kill): 7,500 µg/kg N/R TXAPA9 4,621,1962
intravenous
rat 		lethal dose (50 percent kill): 65 mg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other esterases BIJOAK 67,187,1957
oral
guinea pig 		lethal dose (50 percent kill): 110 mg/kg N/R TXAPA9 4,621,1962
oral
rat 		lethal dose (50 percent kill): 30 mg/kg N/R FMCHA2 -,C197,1991
skin
rat 		lethal dose (50 percent kill): 85 mg/kg N/R PHJOAV 185,361,1960
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 40 mg/kg N/R 30ZDA9 -,346,1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.05 mg/m3 (skin, sen) ( intermittent,V) DTLVS* TLV/BEI,2003
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value Not Classifiable as a Human Carcinogen DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
DTTIAF 80,485,1973
TOXICOLOGY REVIEW
RREVAH 63,1,1976


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85DPAN "Wirksubstanzen der Pflanzenschutz und Schadlingsbekampfungsmittel," Perkow, W., Berlin, Verlag Paul Parey, 1971-1976
BIJOAK Biochemical Journal. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1906-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
DTTIAF Deutsche Tieraerztliche Wochenschrift. (Hanover, Fed. Rep. Ger.) V.1-77, 1893-1970.
FMCHA2 Farm Chemicals Handbook. (Meister Pub., 37841 Euclid Ave., Willoughy, OH 44094)
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
PHJOAV Pharmaceutical Journal. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London, SE1 7JN, UK) V.131- 1933-
RREVAH Residue Reviews. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1962-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used to control aphid vectors of virus diseases, whiteflies, leafhoppers and sawflies

RTECS Compound Description:
   Agricultural Chemical
   Mutagen

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