The Registry of Toxic Effects of Chemical Substances

Phosphorothioic acid, O,O - dimethyl O - (2 - (ethylthio) ethyl) ester, mixed with O,O - dimethyl S - (2 - (ethylthio) ethyl) ester (7:3)

RTECS #: TG1760000

CAS #: 8022-00-2

UPDATE: November 2004 MW: 230.30 MF: C6H15O3PS2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. REFERENCES:

SYNONYMS:

  1. Bayer 21/116
  2. Demeton methyl
  3. Duratox
  4. Metasystox
  5. Methyl demeton
  1. Methyl demeton (ACGIH)
  2. Methyl systox
  3. Methyl - mercaptophos
  4. Methylmerkaptofos (Czech)
  5. S (and O) - 2 - (Ethylthio) ethyl O,O - dimethyl phosphorothioate


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 200 ng/m3/24 hour (1-22 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Other developmental abnormalities

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		HYSAAV 36(1),34,1971
inhalation
rat 		lowest published toxic concentration: 700 ng/m3/24 hour (1-22 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) HYSAAV 36(1),34,1971
inhalation
rat 		lowest published toxic concentration: 100 µg/m3/24 hour (1-22 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) HYSAAV 36(1),34,1971
inhalation
rat 		lowest published toxic concentration: 500 µg/m3/24 hour (1-22 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Effects on newborn: Sex ratio 		HYSAAV 36(1),34,1971


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
cat 		lowest published lethal concentration: 20 mg/m3/4 hour N/R 85GMAT -,85,1982
intravenous
rat 		lethal dose (50 percent kill): 12 mg/kg N/R BJIMAG 15,158,1958
oral
cat 		lowest published lethal dose: 30 mg/kg N/R 85GMAT -,85,1982
oral
mouse 		lethal dose (50 percent kill): 26 mg/kg N/R 85JDAH -,197,1974
oral
rat 		lethal dose (50 percent kill): 75 mg/kg N/R FATOAO 22,259,1959
oral
rabbit 		lethal dose (50 percent kill): 46 mg/kg N/R GISAAA 27(8),97,1962
skin
rat 		lethal dose (50 percent kill): 300 mg/kg N/R WRPCA2 9,119,1970
skin
rabbit 		lowest published lethal dose: 75 mg/kg N/R GTPZAB 2(5),7,1958
unreported route
mammal (species unspecified) 		lethal dose (50 percent kill): 80 mg/kg N/R 30ZDA9 -,346,1971
unreported route
mouse 		lethal dose (50 percent kill): 3,500 µg/kg Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase PCJOAU 3,508,1969


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
cat 		lowest published toxic dose: 470 mg/kg/94 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FATOAO 22,559,1959
oral
rat 		lowest published toxic dose: 404 mg/kg/78 week- intermittent Brain and Coverings: Other degenerative changes

Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		FATOBP 8,122,1973
oral
rat 		lowest published toxic dose: 1,230 mg/kg/18 week- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		FATOAO 22,559,1959


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.5 mg/m3 (skin) DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.5 mg/m3 (skin) DTLVS* 3,165,1971
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.05 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.5 mg/m3, Skin, JAN1993
Occupational Exposure Limit - FRANCE VME 0.5 mg/m3, Skin, JAN1999
Occupational Exposure Limit - GERMANY MAK 0.5 ppm (0.5 mg/m3), Skin, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.1 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.05 ppm (0.5 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.5 mg/m3, Skin, 2003
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.5 mg/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.5 mg/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO METHYL DEMETON-air 10 hour time-weighted average 0.5 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 26540;
Number of Industries 1;
Total Number of Facilities 165;
Number of Occupations 2;
Total Number of Employees Exposed 331


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
N/R


REFERENCES:

CODEN
REFERENCE
30ZDA9 "Chemistry of Pesticides," Melnikov, N.N., New York, Springer-Verlag New York, Inc., 1971
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
85JDAH "Organophosphorus Pesticides: Organic and Biological Chemistry," Eto, M., Cleveland, OH, CRC Press, Inc., 1974
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939-
FATOBP Farmakologiya i Toksikologiya (Kiev). Pharmacology and Toxicology. (Kievskii Nauchno- Issledovatel'skii Institut Farmakologii i Toksikologii, Kiev, USSR) No.1- 1964-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967-
WRPCA2 World Review of Pest Control. (London, UK) V.1-10, 1962-71. Discontinued.

RTECS Compound Description:
   Agricultural Chemical
   Reproductive Effector

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