The Registry of Toxic Effects of Chemical Substances

Phosphorous acid, triethyl ester

RTECS #: TH1130000

CAS #: 122-52-1

UPDATE: January 1997 MW: 166.18 MF: C6H15O3P


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. NIOSH DOCUMENTATION AND SURVEILLANCE:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. Fosforyn trojetylowy (Czech)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
mammal (species unspecified) 		100 mg mild MEPAAX 29,393,1978
eye
rabbit 		100 mg moderate ATDAEI 1,218,1992
skin
mammal (species unspecified) 		500 mg mild MEPAAX 29,393,1978
skin
rabbit 		500 mg mild ATDAEI 1,218,1992


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 6,203 mg/m3/6 hour Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands 		ATDAEI 1,218,1992
inhalation
rat 		lethal concentration (50 percent kill): 11,063 mg/m3/6 hour Lung, Thorax, or Respiration: Respiratory depression

Lung, Thorax, or Respiration: Other changes

Gastrointestinal: Changes in structure or function of salivary glands 		ATDAEI 1,218,1992
intraperitoneal
mouse 		lethal dose : >500 mg/kg N/R CBCCT* 5,286,1953
oral
mouse 		lethal dose (50 percent kill): 3,720 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		ATDAEI 1,218,1992
oral
rat 		lethal dose (50 percent kill): 1,840 mg/kg Behavioral: Ataxia

Lung, Thorax, or Respiration: Respiratory stimulation 		ATDAEI 1,218,1992
skin
rabbit 		lethal dose (50 percent kill): 2,800 mg/kg N/R ATDAEI 1,218,1992


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 84307;
Number of Industries 3;
Total Number of Facilities 38;
Number of Occupations 18;
Total Number of Employees Exposed 5,414


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
ATDAEI Acute Toxicity Data. Journal of the American College of Toxicology, Part B. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1- 1990-
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
MEPAAX Medycyna Pracy. Industrial Medicine. (Ars-Polona, POB 1001, 00-068 Warsaw 1, Poland) V.1- 1950-

RTECS Compound Description:
   Primary Irritant

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