The Registry of Toxic Effects of Chemical Substances

Phosphoryl chloride

RTECS #: TH4897000

CAS #: 10025-87-3

UPDATE: November 2004 MW: 153.32 MF: Cl3OP


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. ACUTE TOXICITY DATA:
  3. OTHER MULTIPLE DOSE DATA:
  4. REVIEWS:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Fosforoxychlorid (Czech)
  2. Oxychlorid fosforecny (Czech)
  3. Phosphorus oxychloride
  4. Phosphorus oxychloride (ACGIH)
  1. Phosphorus oxytrichloride
  2. Phosphoryl trichloride
  3. Trichlorophosphine oxide
  4. Trichlorophosphorus oxide


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
guinea pig 		lethal concentration (50 percent kill): 53 ppm/4 hour Eye: Other eye effects

Behavioral: Irritability

Lung, Thorax, or Respiration: Dyspnea 		AIHAAP 25,470,1964
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 0.48 mg/m3 Lung, Thorax, or Respiration: Cough VCVN5* -,72,1993
inhalation
mouse 		lethal concentration (50 percent kill): 404 mg/m3/2 hour N/R WDZAEK 6,98,1992
inhalation
mouse 		lowest published lethal concentration: 48 mg/m3/36 minute N/R VCVN5* -,72,1993
inhalation
mouse 		lowest published lethal concentration: 5.7 mg/m3/4 hour N/R VCVN5* -,72,1993
inhalation
rat 		lethal concentration (50 percent kill): 32 ppm/4 hour N/R 28ZPAK -,17,1972
inhalation
rat 		lowest published lethal concentration: 48 mg/m3/36 minute N/R VCVN5* -,72,1993
inhalation
rat 		lowest published lethal concentration: 5.7 mg/m3/4 hour N/R VCVN5* -,72,1993
oral
mouse 		lethal dose (50 percent kill): 327 mg/kg N/R WDZAEK 6,98,1992
oral
rat 		lethal dose (50 percent kill): 36 mg/kg Gastrointestinal: Other changes

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0534840
oral
rat 		lethal dose (50 percent kill): 380 mg/kg N/R VCVN5* -,72,1993
skin
rabbit 		lowest published lethal dose: 1 gm/kg Behavioral: Muscle weakness

Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0534840


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mammal (species unspecified) 		lowest published toxic concentration: 1,340 µg/m3/17 week- intermittent Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi

Musculoskeletal: Osteoporosis

Immunological Including Allergic: Other immediate (humoral): uticaria, allergic rhinitis, serum sickness (multiple organ involvement) 		JHEMA2 21,387,1977
inhalation
rat 		lowest published toxic concentration: 4 mg/m3/50 day- intermittent Lung, Thorax, or Respiration: Other changes WDZAEK 6,98,1992
oral
mouse 		lowest published toxic dose: 480 mg/kg/60 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes 		WDZAEK 6,98,1992
oral
rat 		lowest published toxic dose: 480 mg/kg/60 day- intermittent Liver: Other changes

Kidney, Ureter, and Bladder: Other changes

Blood: Other changes 		WDZAEK 6,98,1992


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.1 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.1 ppm (0.6 mg/m3), short term exposure limit 0.5 ppm, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.2 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.1 ppm (0.63 mg/m3), short term exposure limit 0.5 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.1 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 0.5 ppm (3 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.1 ppm (0.6 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY MAK 0.2 ppm (1 mg/m3), JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.6 mg/m3, 2003
Occupational Exposure Limit - RUSSIA short term exposure limit 0.05 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.1 ppm (0.6 mg/m3), KZG- week 0.2 ppm (1.2 mg/m3), JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 0.5 ppm (3 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.2 ppm (1.3 mg/m3), short term exposure limit 0.6 ppm, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.1 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.1 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO PHOSPHORUS OXYCHLORIDE-air 10 hour time-weighted average 0.1 ppm;
short term exposure limit 0.5 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81931;
Number of Industries 7;
Total Number of Facilities 155;
Number of Occupations 22;
Total Number of Employees Exposed 7,258
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 81931;
Number of Industries 9;
Total Number of Facilities 165;
Number of Occupations 29;
Total Number of Employees Exposed 12,587;
Total Number of Female Employees Exposed 2,945


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used in the manufacture of plasticizers, hydraulic fluids and gasoline additives
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
28ZPAK "Sbornik Vysledku Toxixologickeho Vysetreni Latek A Pripravku," Marhold, J.V., Institut Pro Vychovu Vedoucicn Pracovniku Chemickeho Prumyclu Praha, Czechoslovakia, 1972
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JHEMA2 Journal of Hygiene, Epidemiology, Microbiology, and Immunology. (Avicenum, Malostranske namesti 28, 11802 Prague 1, Czechoslovakia) V.1- 1957-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.
WDZAEK Weisheng Dulixue Zazhi. Journal of Health Toxicology. (Weisheng Dulixue Zazhi Bianjibu, Dongdaqiao, Chaoyang Menwai, Beijing, Peop. Rep. China) V.1- 1987

Used in the manufacture of plasticizers, hydraulic fluids and gasoline additives

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