The Registry of Toxic Effects of Chemical Substances

Phthalic acid, benzyl butyl ester

RTECS #: TH9990000

CAS #: 85-68-7

UPDATE: May 2005 MW: 312.39 MF: C19H20O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. AI3 - 14777
  2. BBP
  3. Palatinol BB
  4. 1,2 - Benzenedicarboxylic acid, butyl phenylmethyl ester
  5. Benzyl - butylester kyseliny ftalove (Czech)
  6. Benzyl butyl phthalate
  7. Benzyl n - butyl phthalate
  1. Butyl benzyl phthalate
  2. n - Butyl benzyl phthalate
  3. Butyl phenylmethyl 1,2 - benzenedicarboxylate
  4. NCI - C54375
  5. Santicizer 160
  6. Sicol 160
  7. Unimoll BB


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
morphological transform hamster embryo 2 mg/L MUREAV 356,85,1996


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 9,100 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Other effects to embryo or fetus 		NTIS** PB91-129999
oral
mouse 		lowest published toxic dose: 23,300 mg/kg (6-15 day pregnant) Reproductive: Other effects on female NTIS** PB91-129999
oral
mouse 		lowest published toxic dose: 9.1 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Other developmental abnormalities 		NTIS** #PB91-129999
oral
mouse 		lowest published toxic dose: 23.3 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) NTIS** #PB91-129999
oral
mouse 		lowest published toxic dose: 562 mg/kg (8 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) REPTED 17,575,2003
oral
mouse 		lowest published toxic dose: 1.12 gm/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death REPTED 17,575,2003
oral
mouse 		lowest published toxic dose: 1,686 mg/kg (8 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 17,575,2003
oral
rat 		lowest published toxic dose: 21 gm/kg (14 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		TOXID9 4,136,1984
oral
rat 		lowest published toxic dose: 16,400 mg/kg (6-15 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** PB90-115346
oral
rat 		lowest published toxic dose: 16,400 mg/kg (6-15 day pregnant) Reproductive: Other effects to embryo or fetus

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		NTIS** PB90-115346
oral
rat 		lowest published toxic dose: 4,900 mg/kg (1-7 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJATDK 12,57,1992
oral
rat 		lowest published toxic dose: 154 gm/kg (10 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Effects on fertility: Male fertility index (e.g., # males impregnating females per # males exposed to fertile nonpregnant females) 		NTPTR* NTP-TR-458,1997
oral
rat 		lowest published toxic dose: 4,500 mg/kg (0-8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 12,127,1998
oral
rat 		lowest published toxic dose: 1,500 mg/kg (6 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		JJATDK 19,357,1999
oral
rat 		lowest published toxic dose: 11,600 mg/kg (2 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system EVHPAZ 103,1136,1995
oral
rat 		lowest published toxic dose: 369.8 mg/kg (1-22 day pregnant/21 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		RTOPDW 26,330,1997
oral
rat 		lowest published toxic dose: 119 gm/kg (14 week male/14 week prior to copulation-3 week after birth) Reproductive: Specific developmental abnormalities: Respiratory system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 24 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 24 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Cardiovascular (circulatory) system

Reproductive: Effects on newborn: Behavioral 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 5 gm/kg (14 week male/14 week prior to copulation-21 day after birth) Reproductive: Effects on newborn: Physical REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 2,700 mg/kg (6-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Specific developmental abnormalities: Musculoskeletal system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 5,800 mg/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 7,500 mg/kg (6-15 day pregnant) Reproductive: Specific developmental abnormalities: Eye, ear REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 11,250 mg/kg (6-20 day pregnant) Reproductive: Specific developmental abnormalities: Central nervous system

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 5,700 µg/kg (2 week prior to copulation-22 week after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		EVHPAZ 103,1136,1995
oral
rat 		lowest published toxic dose: 11.3 mg/kg (10 week prior to copulation-22 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain)

Reproductive: Effects on newborn: Delayed effects 		EVHPAZ 103,1136,1995
oral
rat 		lowest published toxic dose: 1,100 mg/kg (1-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetal death 		REPTED 8,231,1994
oral
rat 		lowest published toxic dose: 12.8 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Other developmental abnormalities 		TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 43 gm/kg (1-29 day male/14 day prior to copulation-6 day after birth) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 85 gm/kg (1-29 day male/14 day prior to copulation-6 day after birth) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on newborn: Viability index (e.g., # alive at day 4 per # born alive) 		TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 20,000 mg/kg (1-20 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 8,000 mg/kg (6-13 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 11 gm/kg (6-15 day pregnant) Reproductive: Other developmental abnormalities NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 16.4 gm/kg (6-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 3,000 mg/kg (15-17 day pregnant) Reproductive: Effects on embryo or fetus: Fetal death

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 16,71,2002
oral
rat 		lowest published toxic dose: 1,500 mg/kg (15-17 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,71,2002
oral
rat 		lowest published toxic dose: 5,000 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat 		lowest published toxic dose: 1,687 mg/kg (10 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		REPTED 17,575,2003
oral
rat 		lowest published toxic dose: 42.8 gm/kg (7 day male/7 day prior to copulation-21 day after birth) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 18,1,2004
oral
rat 		lowest published toxic dose: 750 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Blood and lymphatic systems (including spleen and marrow)

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities 		REPTED 18,1,2004
oral
rat 		lowest published toxic dose: 750 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Central nervous system REPTED 18,1,2004
oral
rat 		lowest published toxic dose: 9,000 mg/kg (7 day male/7 day prior to copulation/22 day pregnant) Reproductive: Other developmental abnormalities REPTED 18,1,2004
oral
rat 		lowest published toxic dose: 9,000 mg/kg (14-22 day pregnant/3 day after birth) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		REPTED 18,1,2004


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 433 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia

Blood: Lymphoma including Hodgkin's disease 		NTPTR* NTP-TR-213,1982
oral
rat 		toxic dose : 437 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		EVHPAZ 65,271,1986
oral
rat 		lowest published toxic dose: 364 gm/kg/2 year- continuous Tumorigenic: Carcinogenic by RTECS criteria

Gastrointestinal: Tumors 		NTPTR* NTP-TR-458,1997
oral
rat 		lowest published toxic dose: 117,600 mg/kg/28 week- continuous Tumorigenic: Carcinogenic by RTECS criteria

Blood: Leukemia 		NTIS** PB83-118398
oral
rat 		lowest published toxic dose: 360,500 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB98-131089
oral
rat 		lowest published toxic dose: 865,200 mg/kg/103 week- continuous Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Kidney, Ureter, and Bladder: Bladder tumors 		NTIS** PB98-131089
oral
rat 		lowest published toxic dose: 524,160 mg/kg/104 week- continuous Tumorigenic: Neoplastic by RTECS criteria

Gastrointestinal: Tumors 		NTIS** PB98-131014


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,160 mg/kg N/R EVHPAZ 4,3,1973
oral
guinea pig 		lethal dose (50 percent kill): 13,750 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 24(3),25,1980
oral
mouse 		lethal dose (50 percent kill): 4,170 mg/kg N/R IMEMDT 29,193,1982
oral
mouse 		lethal dose : 2.3 gm/kg N/R REPTED 17,575,2003
oral
mouse 		lowest published toxic dose: 1,124 mg/kg Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 17,575,2003
oral
rat 		lethal dose (50 percent kill): 2,330 mg/kg N/R IMEMDT 29,193,1982
skin
mouse 		lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA 39(6),25,1974
skin
rat 		lethal dose (50 percent kill): 6,700 mg/kg N/R GISAAA 39(6),25,1974
skin
rabbit 		lethal dose (50 percent kill): >10 gm/kg N/R TIHEEC 3,79,1987
unreported route
mouse 		lethal dose (50 percent kill): 13,700 µg/kg N/R GTPZAB 32(7),52,1988


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 2,100 mg/m3/6 hour/4 week- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TIHEEC 3,79,1987
inhalation
rat 		lowest published toxic concentration: 789 mg/m3/6 hour/13 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		TIHEEC 3,79,1987
oral
mouse 		lowest published toxic dose: 273 gm/kg/13 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTPTR* NTP-TR-213,1982
oral
mouse 		lowest published toxic dose: 9.1 gm/kg/10 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB91-129999
oral
mouse 		lowest published toxic dose: 23.3 gm/kg/10 day- continuous Behavioral: Food intake (animal)

Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB91-129999
oral
mouse 		lowest published toxic dose: 23.3 gm/kg/10 day- continuous Behavioral: Fluid intake NTIS** #PB91-129999
oral
rat 		lowest published toxic dose: 56 gm/kg/4 week- continuous Behavioral: Food intake (animal)

Blood: Hemorrhage

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TIHEEC 3,79,1987
oral
rat 		lowest published toxic dose: 68,250 mg/kg/91 day- continuous Liver: Changes in liver weight JACTDZ 11,1,1992
oral
rat 		lowest published toxic dose: 38,402 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		TIHEEC 3,79,1987
oral
rat 		lowest published toxic dose: 21 gm/kg/14 day- continuous Kidney, Ureter, and Bladder: Changes in bladder weight

Related to Chronic Data: Changes in prostate weight

Related to Chronic Data: Changes in testicular weight 		TXCYAC 35,189,1985
oral
rat 		lowest published toxic dose: 51,450 mg/kg/21 day- continuous Liver: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		NTIS** OTS0536510
oral
rat 		lowest published toxic dose: 14,100 mg/kg/141 day- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Kidney, Ureter, and Bladder: Changes in kidney weight 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 70,500 mg/kg/141 day- intermittent Endocrine: Evidence of thyroid hypofunction

Related to Chronic Data: Changes in ovarian weight 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 9,800 mg/kg/14 week- intermittent Gastrointestinal: Changes in structure or function of salivary glands

Endocrine: Other changes 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 49,000 mg/kg/14 week- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 10,500 mg/kg/21 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 32,000 mg/kg/64 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Endocrine: Changes in thyroid weight 		REPTED 14,513,2000
oral
rat 		lowest published toxic dose: 16,000 mg/kg/10 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 7,500 mg/kg/10 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases 		REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 2,700 mg/kg/10 day- intermittent Blood: Changes in spleen REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 8,700 mg/kg/15 day- intermittent Blood: Changes in spleen

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Transaminases

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 18,750 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 5,250 mg/kg/15 day- intermittent Liver: Changes in liver weight REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 4,050 mg/kg/15 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 6,750 mg/kg/15 day- intermittent Kidney, Ureter, and Bladder: Changes in kidney weight REPTED 14,417,2000
oral
rat 		lowest published toxic dose: 117,600 mg/kg/28 week- continuous Liver: Changes in liver weight

Blood: Changes in spleen 		NTIS** PB83-118398
oral
rat 		lowest published toxic dose: 700 mg/kg/7 day- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Changes in ovarian weight

Related to Chronic Data: Changes in uterine weight 		REPTED 8,231,1994
oral
rat 		lowest published toxic dose: 8,000 mg/kg/8 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 13,000 mg/kg/20 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 29,000 mg/kg/29 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 7,000 mg/kg/7 day- intermittent Behavioral: Food intake (animal) TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 7,000 mg/kg/14 day- intermittent Behavioral: Food intake (animal) TXCYAC 99,191,1995
oral
rat 		lowest published toxic dose: 4.2 gm/kg/10 day- continuous Behavioral: Fluid intake NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 11 gm/kg/10 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 7.7 gm/kg/7 day- continuous Behavioral: Food intake (animal) NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 4.4 gm/kg/4 day- continuous Behavioral: Fluid intake NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 16.4 gm/kg/10 day- continuous Kidney, Ureter, and Bladder: Changes in kidney weight NTIS** #PB90-115346/AS
oral
rat 		lowest published toxic dose: 1,500 mg/kg/3 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 16,71,2002
oral
rat 		lowest published toxic dose: 700 mg/kg/14 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Liver: Other changes 		FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Changes in liver weight FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 42,750 mg/kg/57 day- intermittent Liver: Changes in liver weight REPTED 18,1,2004


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 73,115,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 29,193,1982
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 29, 193,1982
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 73,115,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 73,115,1999
TOXICOLOGY REVIEW
JACTDZ 11,1,1992
TOXICOLOGY REVIEW
MUREAV 543,201,2003
TOXICOLOGY REVIEW
MUREAV 5432012003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3, KTV 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80249;
Number of Industries 93;
Total Number of Facilities 9,594;
Number of Occupations 74;
Total Number of Employees Exposed 66,289
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80249;
Number of Industries 158;
Total Number of Facilities 27,154;
Number of Occupations 119;
Total Number of Employees Exposed 331,841;
Total Number of Female Employees Exposed 59,743


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9016;8EHQ-0892-9174
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-8845
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (feed);clear evidence:rat
NTP Carcinogenesis Studies (feed);some evidence:rat NTPTR* NTP-TR-458,1997
NCI Carcinogenesis Studies (feed);equivocal evidence:rat
NCI Carcinogenesis Studies (feed);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
JJATDK JAT, Journal of Applied Toxicology. (John Wiley & Sons Ltd., Baffins Lane, Chichester, W. Sussex PO19 1UD, UK) V.1- 1981-
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Used as plasticizer

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

ALT CAS #: 58128-78-2
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