The Registry of Toxic Effects of Chemical Substances

Phthalic acid, diisooctyl ester

RTECS #: TI1300000

CAS #: 27554-26-3

UPDATE: December 2000 MW: 390.62 MF: C24H38O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. ACUTE TOXICITY DATA:
  4. STANDARDS AND REGULATIONS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Corflex 880
  2. Diisooctyl phthalate
  3. Flexol Plasticizer DIOP
  4. 1,2 - Benzenedicarboxylic acid, diisooctyl ester
  1. Hexaplas M/O
  2. Isooctyl phthalate
  3. Phthalic acid, bis (6 - methylheptyl) ester


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		500 mg open irritation test mild UCDS** 6/11/1965


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 2,769 mg/kg N/R GTPZAB 17(11),51,1973
oral
rat 		lethal dose (50 percent kill): 22 gm/kg N/R EVHPAZ 3,61,1973
skin
rabbit 		lethal dose (50 percent kill): 12,600 µL/kg N/R UCDS** 6/11/1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - DENMARK time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3, KTV 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, SEP2000


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83445;
Number of Industries 8;
Total Number of Facilities 253;
Number of Occupations 19;
Total Number of Employees Exposed 4,770
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83445;
Number of Industries 3;
Total Number of Facilities 387;
Number of Occupations 5;
Total Number of Employees Exposed 5,416;
Total Number of Female Employees Exposed 158


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used for PVC and its copolymers, providing good performance and heat and light stability
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
EVHPAZ EHP, Environmental Health Perspectives. (U.S. Government Printing Office, Supt of Documents, Washington, DC 20402) No.1- 1972-
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

Used for PVC and its copolymers, providing good performance and heat and light stability

RTECS Compound Description:
   Primary Irritant

ALT CAS #: 1330-91-2
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