The Registry of Toxic Effects of Chemical Substances

Phthalic acid, dibutyl ester

RTECS #: TI0875000

CAS #: 84-74-2

UPDATE: May 2005 MW: 278.38 MF: C16H22O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. Dibutyl 1,2 - benzenedicarboxylate
  2. Di - n - butylester kyseliny ftalove (Czech)
  3. Dibutyl phthalate
  4. Di - n - butyl phthalate
  5. Dibutyl phthalate (ACGIH:OSHA)
  6. Palatinol C
  7. o - Benzenedicarboxylic acid, dibutyl ester
  8. Benzene - o - dicarboxylic acid di - n - butyl ester
  9. n - Butylphthalate
  10. Celluflex DPB
  11. DBP (ester)
  12. Dibutyl o - phthalate
  13. Elaol
  1. Ergoplast FOB
  2. Genoplast B
  3. Hatcol DBP
  4. Hexaplas M/B
  5. Kodaflex DBP
  6. Monocizer DBP
  7. Polycizer DBP
  8. PX 104
  9. RCRA waste number U069
  10. Staflex DBP
  11. Unimoll DB
  12. Vestinol C
  13. Witcizer 300


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis hamster fibroblast 30 mg/L/24 hour MUREAV 48,337,1977
DNA damage human lymphocyte 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 354 mmol/L MUREAV 467,21,2000
DNA damage human other cell types 216 µmol/L/60 minute EMMUEG 35,9,2000
DNA damage human lymphocyte 354 mmol/L/60 minute TCMUD8 21,189,2001
mutation in microorganisms Salmonella typhimurium 100 µg/plate (+enzymatic activation step) JTEHD6 16,61,1985


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
rat 		lowest published toxic dose: 1,017 mg/kg (5-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) JPMSAE 61,51,1972
intraperitoneal
rat 		lowest published toxic dose: 305 mg/kg (5-15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JPMSAE 61,51,1972
intraperitoneal
rat 		lowest published toxic dose: 6 gm/kg (3-9 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) EVHPAZ 3,91,1973
intraperitoneal
rat 		lowest published toxic dose: 6 mL/kg (3-9 day pregnant) Reproductive: Effects on newborn: Weaning or lactation index (e.g., # alive at weaning per # alive at day 4) EVHPAZ 3,91,1973
oral
guinea pig 		lowest published toxic dose: 14 gm/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 11,141,1982
oral
mouse 		lowest published toxic dose: 7,200 mg/kg (1-18 day pregnant) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth)

Reproductive: Specific developmental abnormalities: Central nervous system 		OEKSDJ 8,29,1977
oral
mouse 		lowest published toxic dose: 8,640 mg/kg (1-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) EVHPAZ 45,65,1982
oral
mouse 		lowest published toxic dose: 20 gm/kg (6-13 day pregnant) Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) TCMUD8 7,29,1987
oral
mouse 		lowest published toxic dose: 16,800 mg/kg (7 day male) Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Other effects on male 		TOLED5 5,413,1980
oral
mouse 		lowest published toxic dose: 46,200 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) ENVRAL 22,245,1980
oral
rat 		lowest published toxic dose: 24 gm/kg (20 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		WDZAEK 3,153,1989
oral
rat 		lowest published toxic dose: 6,750 mg/kg (0-8 day pregnant) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants) 		CGANE7 39,189,1999
oral
rat 		lowest published toxic dose: 2,250 mg/kg (7-9 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue) 		TXCYAC 86,163,1994
oral
rat 		lowest published toxic dose: 2,520 mg/kg (1-21 day pregnant) Reproductive: Effects on embryo or fetus: Extra embryonic structures (e.g., placenta, umbilical cord) TXAPA9 26,253,1973
oral
rat 		lowest published toxic dose: 8,820 mg/kg (7-15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Effects on embryo or fetus: Fetal death 		TOLED5 69,197,1993
oral
rat 		lowest published toxic dose: 19 gm/kg (3-22 day pregnant/3-20 day after birth) Reproductive: Maternal effects: Uterus, cervix, vagina

Reproductive: Effects on newborn: Physical

Reproductive: Effects on newborn: Delayed effects 		TOSCF2 43,47,1998
oral
rat 		lowest published toxic dose: 1,500 mg/kg (15 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus)

Reproductive: Specific developmental abnormalities: Craniofacial (including nose and tongue)

Reproductive: Specific developmental abnormalities: Musculoskeletal system 		JJATDK 17,223,1997
oral
rat 		lowest published toxic dose: 6,750 mg/kg (0-8 day pregnant) Reproductive: Other effects on female

Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on fertility: Litter size (e.g., # fetuses per litter; measured before birth) 		REPTED 14,13,2000
oral
rat 		lowest published toxic dose: 2 gm/kg (15 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Sex ratio 		TOSCF2 45,212,1998
oral
rat 		lowest published toxic dose: 1.5 gm/kg (15 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TOSCF2 45,212,1998
oral
rat 		lowest published toxic dose: 501 mg/kg (10 day pregnant) Reproductive: Other effects to embryo or fetus PHTOEH 89,104,2001
oral
rat 		lowest published toxic dose: 11.2 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 77.5 gm/kg (17 week prior to copulation) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 2.3 gm/kg (7 day male/7 day prior to copulation/21 day pregnant) Reproductive: Effects on newborn: Live birth index (Litter size (e.g., # fetuses per litter; measured after birth) NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 66 mg/kg (multigenerations) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 651 mg/kg (multigenerations) Reproductive: Effects on fertility: Mating performance (e.g., # sperm positive females per # females mated; # copulations per # estrus cycles)

Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) 		NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 651 mg/kg (multigenerations) Reproductive: Specific developmental abnormalities: Hepatobiliary system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) 		NTIS** #PB92111996
oral
rat 		lowest published toxic dose: 3,500 mg/kg (12-18 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system REPTED 16,10,2002
oral
rat 		lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Specific developmental abnormalities: Urogenital system 		REPTED 16,10,2002
oral
rat 		lowest published toxic dose: 16.5 gm/kg (7-22 day pregnant/17 day after birth) Reproductive: Effects on newborn: Other postnatal measures or effects JJTHEC 65(A),813,2002
oral
rat 		lowest published toxic dose: 5,500 mg/kg (7-17 day after birth) Reproductive: Effects on newborn: Behavioral REPTED 17,475,2003
oral
rat 		lowest published toxic dose: 5,000 mg/kg (14-18 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),272,2003
oral
rat 		lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) TOXID9 72(Suppl 1),273,2003
oral
rat 		lowest published toxic dose: 5,000 mg/kg (12-21 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 72(Suppl 1),275,2003
oral
rat 		lowest published toxic dose: 4,000 mg/kg (12-19 day pregnant) Reproductive: Effects on embryo or fetus: Cytological changes (including somatic cell genetic material) TOSCF2 73,431,2003
oral
rat 		lowest published toxic dose: 28 gm/kg (4 week male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) REPTED 18,35,2004
oral
rat 		lowest published toxic dose: 600 mg/kg (multigeneration) Reproductive: Specific developmental abnormalities: Endocrine system

Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Other developmental abnormalities 		REPTED 18,1,2004
oral
rabbit 		lowest published toxic dose: 5,600 mg/kg (15-29 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system

Reproductive: Effects on newborn: Delayed effects 		TOSCF2 72,301,2003
unreported route
rat 		lowest published toxic dose: 1,000 mg/kg (16-19 day pregnant) Reproductive: Specific developmental abnormalities: Urogenital system TOXID9 42,176,1998


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 25 gm/m3/2 hour N/R 85GMAT -,44,1982
inhalation
rat 		lethal concentration (50 percent kill): 4,250 mg/m3 N/R GTPZAB 17(8),26,1973
intramuscular
rat 		lethal dose (50 percent kill): >8 gm/kg N/R 14CYAT 2,1904,1963
intraperitoneal
mouse 		lethal dose (50 percent kill): 3,570 mg/kg N/R JSCCA5 28,667,1977
intraperitoneal
rat 		lethal dose (50 percent kill): 3,050 µL/kg N/R JPMSAE 61,51,1972
intravenous
mouse 		lethal dose (50 percent kill): 720 mg/kg N/R KEKHB8 (3),19,1973
oral
guinea pig 		lethal dose (50 percent kill): 10 gm/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Withdrawal

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 24(3),25,1980
oral
human 		lowest published toxic dose: 140 mg/kg Behavioral: Hallucinations, distorted perceptions

Gastrointestinal: Nausea or vomiting

Kidney, Ureter, and Bladder: Other changes 		SMWOAS 84,1243,1954
oral
mammal (species unspecified) 		lethal dose (50 percent kill): 5 gm/kg N/R GISAAA 39(4),86,1974
oral
mouse 		lethal dose (50 percent kill): 3,474 mg/kg N/R WDZAEK 5,264,1991
oral
rat 		lethal dose (50 percent kill): 7,499 mg/kg N/R WDZAEK 5,264,1991
oral
rat 		lowest published toxic dose: 2,394 mg/kg Reproductive: Paternal effects: Testes, epididymis, sperm duct TOLED5 138,215,2003
skin
rat 		lowest published lethal dose: 6 gm/kg N/R 85GMAT -,44,1982
skin
rabbit 		lethal dose (50 percent kill): >20 mL/kg N/R UCDS** 12/29/1971
unreported route
mouse 		lethal dose (50 percent kill): 8,140 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 55(6),86,1990
unreported route
rat 		lethal dose (50 percent kill): 9,410 mg/kg Behavioral: General anesthetic

Behavioral: Ataxia

Lung, Thorax, or Respiration: Dyspnea 		GISAAA 55(6),86,1990


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 900 mg/m3/6 hour/35 day- intermittent Brain and Coverings: Changes in brain weight

Blood: Normocytic anemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		GTPZAB 17(8),26,1973
intramuscular
mouse 		lowest published toxic dose: 151,200 mg/kg/18 week- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** #PB85144798
intramuscular
mouse 		lowest published toxic dose: 151,200 mg/kg/18 week- continuous Liver: Changes in liver weight

Related to Chronic Data: Changes in uterine weight 		NTIS** #PB85144798
intramuscular
rat 		lowest published toxic dose: 4,557 mg/kg/1 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain NTIS** #PB92111996
intramuscular
rat 		lowest published toxic dose: 77,469 mg/kg/17 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight 		NTIS** #PB92111996
intramuscular
rat 		lowest published toxic dose: 77,469 mg/kg/17 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in kidney weight

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		NTIS** #PB92111996
intraperitoneal
rat 		lowest published toxic dose: 12 mL/kg/7 day- intermittent Reproductive: Maternal effects: Parturition

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		EVHPAZ 3,91,1973
oral
mouse 		lowest published toxic dose: 54,600 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight 		NTPTR* NIH-95-3353
oral
rat 		lowest published toxic dose: 96,750 mg/kg/45 day- intermittent Endocrine: Other changes

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(6),102,1968
oral
rat 		lowest published toxic dose: 42 gm/kg/28 day- continuous Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		NTIS** OTS0530401
oral
rat 		lowest published toxic dose: 4 gm/kg/4 day- intermittent Related to Chronic Data: Changes in testicular weight TXAPA9 41,609,1977
oral
rat 		lowest published toxic dose: 27,300 mg/kg/13 week- continuous Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Blood: Normocytic anemia 		NTPTR* NIH-95-3353
oral
rat 		lowest published toxic dose: 22,750 mg/kg/1 year- continuous Behavioral: Food intake (animal)

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		TXAPA9 26,253,1973
oral
rat 		lowest published toxic dose: 11,250 mg/kg/9 day- intermittent Related to Chronic Data: Changes in ovarian weight REPTED 14,13,2000
oral
rat 		lowest published toxic dose: 13,500 mg/kg/9 day- intermittent Behavioral: Alteration of classical conditioning

Endocrine: Estrogenic 		REPTED 14,13,2000
oral
rat 		lowest published toxic dose: 4,500 mg/kg/9 day- intermittent Behavioral: Food intake (animal)

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 14,13,2000
oral
rat 		lowest published toxic dose: 6,750 mg/kg/9 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in uterine weight 		REPTED 14,13,2000
oral
rat 		lowest published toxic dose: 28,000 mg/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Reproductive: Paternal effects: Prostate, seminal vesicle, Cowper's gland, accessory glands 		ATSUDG 4,452,1980
oral
rat 		lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Related to Chronic Data: Changes in testicular weight 		ARTODN 64,148,1990
oral
rat 		lowest published toxic dose: 5 gm/kg/10 day- intermittent Reproductive: Paternal effects: Testes, epididymis, sperm duct

Related to Chronic Data: Changes in testicular weight 		JJTHEC 65,813,2002
oral
rat 		lowest published toxic dose: 20 gm/kg/10 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JJTHEC 65,813,2002
oral
rat 		lowest published toxic dose: 700 mg/kg/14 day- intermittent Endocrine: Changes in adrenal weight

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Hepatic microsomal mixed oxidase (dealkylation, hydroxylation, etc.) 		FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 2,800 mg/kg/14 day- intermittent Liver: Other changes

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other oxidoreductases

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Other transferases 		FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 14 gm/kg/14 day- intermittent Liver: Changes in liver weight FCTOD7 42,107,2004
oral
rat 		lowest published toxic dose: 8,000 mg/kg/8 day- intermittent Endocrine: Other changes

Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol) 		EVHPAZ 111,139,2003
oral
rat 		lowest published toxic dose: 3,750 mg/kg/15 day- intermittent Endocrine: Evidence of thyroid hypofunction TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 7,500 mg/kg/15 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction 		TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 15,000 mg/kg/15 day- intermittent Liver: Changes in liver weight

Endocrine: Evidence of thyroid hypofunction

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		TOSCF2 69,92,2002
oral
rat 		lowest published toxic dose: 28,000 mg/kg/4 week- intermittent Kidney, Ureter, and Bladder: Urine volume decreased or anuria

Kidney, Ureter, and Bladder: Changes in kidney weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		REPTED 18,35,2004
oral
rat 		lowest published toxic dose: 1,680 mg/kg/4 week- intermittent Nutritional and Gross Metabolic: Changes in: Metabolic alkalosis REPTED 18,35,2004
oral
rat 		lowest published toxic dose: 7,000 mg/kg/4 week- intermittent Liver: Changes in liver weight REPTED 18,35,2004
oral
rabbit 		lowest published toxic dose: 33,600 mg/kg/12 week- intermittent Endocrine: Androgenic

Endocrine: Changes in thyroid weight

Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count) 		TOSCF2 72,301,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 5 mg/m3 DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
RREVAH 54,1,1975
TOXICOLOGY REVIEW
EVHPAZ 4,3,1973
TOXICOLOGY REVIEW
CMTVAS 10(3),49,1973
TOXICOLOGY REVIEW
ESKHA5 (93),1,1975
TOXICOLOGY REVIEW
JACTDZ 4(3),267,1985
TOXICOLOGY REVIEW
FAATDF 13,747,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC 54,7740,1989
Environmental Protection Agency (EPA) Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) 1998 STATUS OF PESTICIDES: Cancelled RBREV* -,270,1998
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 5 mg/m3 DTLVS* 3,75,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 5 mg/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 5 mg/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 5 mg/m3, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 5 mg/m3, JAN1999
Occupational Exposure Limit - HUNGARY time-weighted average 2 mg/m3, short term exposure limit 4 mg/m3, Skin, JAN1993
Occupational Exposure Limit - INDIA time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - JAPAN Occupational Exposure Limit 5 mg/m3, JAN1999
Occupational Exposure Limit - NORWAY time-weighted average 3 mg/m3, JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 5 mg/m3, JAN1993
Occupational Exposure Limit - POLAND MAC(time-weighted average) 5 mg/m3, MAC(short term exposure limit) 10 mg/m3, JAN1999
Occupational Exposure Limit - RUSSIA short term exposure limit 0.5 mg/m3, JAN1993
Occupational Exposure Limit - SWEDEN NGV 3 mg/m3, KTV 5 mg/m3, JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 5 mg/m3, JAN1999
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 5 mg/m3, short term exposure limit 10 mg/m3, SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 5 mg/m3
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 5 mg/m3


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO DIBUTYL PHTHALATE-air 10 hour time-weighted average 5 mg/m3 NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 80248;
Number of Industries 192;
Total Number of Facilities 28,100;
Number of Occupations 114;
Total Number of Employees Exposed 258,823
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 80248;
Number of Industries 199;
Total Number of Facilities 31,502;
Number of Occupations 138;
Total Number of Employees Exposed 512,631;
Total Number of Female Employees Exposed 198,249


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
ATSDR TOXICOLOGY PROFILE (NTIS** PB/2001/109104/AS)
EPA GENETOX PROGRAM 1988, Negative: S cerevisiae-reversion
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as plasticizer, also used in specialized vinyl compounds and nail polish removers
EPA TSCA Section 8(d) unpublished health/safety studies
On EPA IRIS database
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Dibutyl phthalate, 5020
NTP Toxicity studies, RPT# TOX-30, October 2000
NTP Carcinogenesis studies; test completed (peer review), October 2000
OSHA ANALYTICAL METHOD #104


REFERENCES:

CODEN
REFERENCE
14CYAT "Industrial Hygiene and Toxicology," 2nd ed., Patty, F.A., ed., New York, John Wiley & Sons, Inc., 1958-63
85GMAT "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
ATSUDG Archives of Toxicology, Supplement. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) No.1- 1978-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
CGANE7 Congenital Anomalies. (Nippon Senten Ijo Gakkai, 377-2 Ono-higashi, Osakasayama, Osaka-Fu 589 Japan) V.27- 1987-
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Used as plasticizer, also used in specialized vinyl compounds and nail polish removers

NIOSH PROFILE (PHTHALATES), SRI, 2/77

NIOSH PROFILE (PHTHALATES), SRC, 3/82

RTECS Compound Description:
   Agricultural Chemical
   Tumorigen
   Mutagen
   Reproductive Effector
   Human Data

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