The Registry of Toxic Effects of Chemical Substances

2 - Picoline

RTECS #: TJ4900000

CAS #: 109-06-8

UPDATE: June 1998 MW: 93.14 MF: C6H7N


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. alpha - Methylpyridine
  2. 2 - Methylpyridine
  3. Picoline
  1. alpha - Picoline
  2. Pyridine, 2 - methyl -
  3. RCRA waste number U191


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
rabbit 		470 mg open irritation test mild UCDS** 2/21/1958


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
sex chromosome loss and nondisjunction Saccharomyes cerevisiae 7,400 ppm MUREAV 163,23,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 9 gm/m3 N/R GISAAA 57(9-10),64,1992
inhalation
rat 		lowest published lethal concentration: 4,000 ppm/4 hour N/R AMIHBC 4,119,1951
intraperitoneal
mouse 		lethal dose (50 percent kill): 529 mg/kg N/R TOXIA6 23,815,1985
intraperitoneal
rat 		lethal dose (50 percent kill): 200 mg/kg Behavioral: Somnolence (general depressed activity) FAATDF 5,920,1985
oral
guinea pig 		lethal dose (50 percent kill): 900 mg/kg N/R HYSAAV 33(10-12),341,1968
oral
mouse 		lethal dose (50 percent kill): 674 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		GISAAA 45(12),62,1980
oral
rat 		lethal dose (50 percent kill): 790 mg/kg Behavioral: Somnolence (general depressed activity)

Behavioral: Convulsions or effect on seizure threshold

Behavioral: Excitement 		GISAAA 45(12),62,1980
skin
rabbit 		lethal dose (50 percent kill): 410 µL/kg N/R AMIHBC 4,119,1951


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 1,072 mg/kg/9 week- intermittent Blood: Change in clotting factors

Blood: Thrombocytopenia

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(12),18,1968
oral
rat 		lowest published toxic dose: 1,810 µg/kg/26 week- intermittent Blood: Change in clotting factors

Blood: Changes in other cell count (unspecified)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: True cholinesterase 		GISAAA 33(12),18,1968


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X3811;
Number of Industries 6;
Total Number of Facilities 132;
Number of Occupations 8;
Total Number of Employees Exposed 11,240;
Total Number of Female Employees Exposed 1,234


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0892-9267
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AMIHBC AMA Archives of Industrial Hygiene and Occupational Medicine. (Chicago, IL) V.2-10, 1950-54. For publisher information, see AEHLAU.
FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1-40, 1981-97. For publisher information, see TOSCF2
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
HYSAAV Hygiene and Sanitation (USSR). English translation of GISAAA. (Springfield, VA) 1964-71. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
TOXIA6 Toxicon. (Pergamon Press Ltd., Headington Hill Hall, Oxford OX3 OBW, UK) V.1- 1962-
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Mutagen
   Primary Irritant

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