The Registry of Toxic Effects of Chemical Substances

Plumbane, tetramethyl -

RTECS #: TP4725000

CAS #: 75-74-1

UPDATE: May 2005 MW: 267.35 MF: C4H12Pb


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. REPRODUCTIVE EFFECTS DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Lead, tetramethyl -
  2. Piombo tetra - metile (Italian)
  3. TML
  4. Tetramethyl lead
  1. Tetramethyl lead (ACGIH:OSHA)
  2. Tetramethylolovo (Czech)
  3. Tetramethylplumbane


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 112 mg/kg (9-11 day pregnant) Reproductive: Effects on fertility: Post- implantation mortality (e.g., dead and/or resorbed implants per total number of implants)

Reproductive: Effects on embryo or fetus: Fetotoxicity (except death, e.g., stunted fetus) 		TXAPA9 21,265,1972
oral
rat 		lowest published toxic dose: 80 mg/kg (9-11 day pregnant) Reproductive: Specific developmental abnormalities: Musculoskeletal system TXAPA9 21,265,1972


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 8,500 mg/m3/30 minute N/R 85JCAE -,1258,1986
inhalation
rat 		lethal concentration : >9,840 mg/m3/1 hour N/R BJIMAG 18,277,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 90 mg/kg N/R MELAAD 54,486,1963
intravenous
rat 		lethal dose (50 percent kill): 88 mg/kg N/R MELAAD 54,486,1963
intravenous
rabbit 		lowest published lethal dose: 90 mg/kg Eye: Other eye effects

Behavioral: Muscle weakness

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		JPETAB 38,161,1930
oral
guinea pig 		lethal dose (50 percent kill): 109 mg/kg N/R YAKUD5 22,455,1980
oral
rat 		lethal dose (50 percent kill): 105 mg/kg N/R MELAAD 54,486,1963
oral
rabbit 		lowest published lethal dose: 24 mg/kg N/R SAIGBL 15,3,1973
parenteral
rat 		lethal dose (50 percent kill): 105 mg/kg N/R AOHYA3 3,226,1961
skin
rabbit 		lowest published lethal dose: 3,391 mg/kg N/R SAIGBL 15,3,1973


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 900 mg/m3/1 hour/5 day- intermittent Brain and Coverings: Other degenerative changes

Behavioral: Irritability

Lung, Thorax, or Respiration: Other changes 		NTIS** OTS0533656-1
intravenous
monkey 		lowest published toxic dose: 42 mg/kg/7 day- intermittent Kidney, Ureter, and Bladder: Other changes in urine composition TOLED5 2,187,1978


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.15 mg(Pb)/m3 (skin) DTLVS* TLV/BEI,2003
TOXICOLOGY REVIEW
85DHAX Pb,255,1972


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.15 mg(Pb)/m3 (skin) DTLVS* 3,253,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.075 mg(Pb)/m3 (skin) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.15 mg(Pb)/m3 (skin) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.15 mg(Pb)/m3 (skin) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.075 mg(Pb)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.05 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.075 mg/m3), Skin, JAN1993
Occupational Exposure Limit - AUSTRIA MAK 0.01 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.007 ppm (0.05 mg/m3), Skin, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.05 mg/m3, Skin, 2003
Occupational Exposure Limit - FINLAND time-weighted average 0.1 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - FRANCE VME 0.15 mg(Pb)/m3, Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 0.15 mg/m3, Skin, JAN1993
Occupational Exposure Limit - GERMANY MAK 0.01 ppm (0.075 mg(Pb)/m3), Skin, JAN1999
Occupational Exposure Limit - HUNGARY short term exposure limit 0.04 mg(Pb)/m3, Carcinogen, JAN1993
Occupational Exposure Limit - HUNGARY time-weighted average 0.005 mg/m3, short term exposure limit 0.01 mg/m3, Skin, JAN1993
Occupational Exposure Limit - NORWAY time-weighted average 0.01 ppm (0.075 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.07 mg/m3, Skin, JAN1993
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - RUSSIA short term exposure limit 0.005 ppm (0.01 mg(Pb)/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 0.05 mg(Pb)/m3, KTV 0.2 mg(Pb)/m3, Skin, JAN1999
Occupational Exposure Limit - SWEDEN NGV 0.05 mg/m3, short term exposure limit 0.2 mg/m3, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.01 ppm (0.075 mg/m3), KZG- week 0.02 ppm, Skin, JAN1999
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.01 ppm (0.075 mg/m3), short term exposure limit 0.02 ppm, Skin, JAN1993
Occupational Exposure Limit - SWITZERLAND time-weighted average 0.1 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 0.07 mg/m3, JAN1993
Occupational Exposure Limit - THAILAND time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - TURKEY time-weighted average 0.2 mg(Pb)/m3, JAN1993
Occupational Exposure Limit - UNITED KINGDOM LTEL 0.15 mg(Pb)/m3, JAN1993
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.15 mg(Pb)/m3 (skin)
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.15 mg(Pb)/m3 (skin)


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO TETRAMETHYLLEAD-air 10 hour time-weighted average 0.075 mg/m3 (Sk) NIOSH* DHHS #92-100,1992
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 71860;
Number of Industries 1;
Total Number of Facilities 7;
Number of Occupations 1;
Total Number of Employees Exposed 7


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as component of anti-knock mixes for gas
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH Analytical Method, 1994: Tetramethyl lead (as Pb), 2534
NTP 11th Report on Carcinogens,2004:Reasonably anticipated to be a human carcinogen


REFERENCES:

CODEN
REFERENCE
85DHAX "Medical and Biologic Effects of Environmental Pollutants Series," Washington, DC, National Academy of Sciences, 1972-77
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AOHYA3 Annals of Occupational Hygiene. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958-
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10-
MELAAD Medicina del Lavoro. Industrial Medicine. (Via S. Barnaba, 8, 20122 Milan, Italy) V.16- 1925-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
SAIGBL Sangyo Igaku. Japanese Journal of Industrial Health. (Nippon Sangyo Eisei Igakkai, Kosu Eisei Bldg., 1-29-8, Shinjuku, Shinjuku-ku, Tokyo 160, Japan) V.1- 1959-
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
YAKUD5 Gekkan Yakuji. Pharmaceuticals Monthly. (Yakugyo Jihosha, Inaoka Bldg., 2-36 Jinbo-cho, Kanda, Chiyoda-ku, Tokyo 101, Japan) V.1- 1959-

Used as component of anti-knock mixes for gas

NIOSH PROFILE (ORGANIC LEAD), SRC, 10/77

RTECS Compound Description:
   Organometallic
   Reproductive Effector

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