The Registry of Toxic Effects of Chemical Substances

Polyvinyl alcohol

RTECS #: TR8100000

CAS #: 9002-89-5

UPDATE: August 2004 MW: N/R MF: (C2H4O)x


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Alcotex 88/05
  2. Alcotex 88/10
  3. Alkotex
  4. Alvyl
  5. Aracet APV
  6. Cipoviol W 72
  7. Covol
  8. Covol 971
  9. Ethenol homopolymer (9CI)
  10. Mowiol
  11. Sumitex H 10
  12. Vibatex S
  13. Vinacol MH
  14. Vinalak
  15. Vinarol
  16. Vinarol DT
  17. Vinarole
  18. Vinarol ST
  19. Vinavilol 2 - 98
  20. Vinnarol
  21. Mowiol N 30 - 88
  22. Vinol
  23. Vinol 125
  24. Vinol 205
  25. Vinol 351
  26. Vinol 523
  27. Vinol unisize
  28. Vinyl alcohol polymer
  29. Vinylon film 2000
  30. Mowiol N 50 - 98
  31. Mowiol N 70 - 98
  32. NM 11
  33. NM 14
  34. Polydesis
  35. Polyvinol
  36. Elvanol
  37. Elvanol 50 - 42
  38. Elvanol 52 - 22
  39. Elvanol 70 - 05
  40. Elvanol 71 - 30
  41. Elvanol 90 - 50
  42. Elvanol 522 - 22
  43. Elvanol 73125G
  44. EP 160
  45. Polysizer 173
  46. Galvatol 1 - 60
  47. Gelvatol
  48. Gelvatol 1 - 30
  49. Gelvatol 1 - 90
  50. Gelvatol 3 - 91
  51. Gelvatol 20 - 30
  52. Gelvatol 2090
  53. GH 20
  54. GL 02
  55. GL 03
  56. GLO 5
  57. GM 14
  58. Gohsenol
  59. Gohsenol AH 22
  1. Gohsenol GH
  2. Gohsenol GH 17
  3. Gohsenol GH 20
  4. Gohsenol GH 23
  5. Gohsenol GL 03
  6. Gohsenol GL 05
  7. Gohsenol GL 08
  8. Gohsenol GM 14
  9. Gohsenol GM 94
  10. Gohsenol GM 14L
  11. Gohsenol KH 17
  12. Gohsenol NH 05
  13. Gohsenol NH 17
  14. Gohsenol NH 18
  15. Gohsenol NH 20
  16. Gohsenol NH 26
  17. Gohsenol NK 114
  18. Gohsenol NL 05
  19. Gohsenol NM 14
  20. Ivalon
  21. Kuralon VP
  22. Kurare poval 1700
  23. Kurare PVA 205
  24. Kurate poval 120
  25. Lemol
  26. Lemol 5 - 88
  27. Lemol 5 - 98
  28. Lemol 12 - 88
  29. Lemol 16 - 98
  30. Lemol 24 - 98
  31. Lemol 30 - 98
  32. Lemol 51 - 98
  33. Lemol 60 - 98
  34. Lemol 75 - 98
  35. Lemol GF - 60
  36. M 13/20
  37. NH 18
  38. PVA 008
  39. PVS 4
  40. Resistoflex
  41. Rhodoviol
  42. Rhodoviol 4/125
  43. Rhodoviol 16/200
  44. Rhodoviol 4 - 125P
  45. Rhodoviol R 16/20
  46. Solvar
  47. Polyviol
  48. Polyviol M 13/140
  49. Polyviol MO 5/140
  50. Polyviol W 25/140
  51. Polyviol W 40/140
  52. Poval 117
  53. Poval 120
  54. Poval 203
  55. Poval 205
  56. Poval 217
  57. Poval 1700
  58. Poval C 17


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
cytogenetic analysis intravaginal
mouse 		0.5 ppb EMMUEG 39,69,2002
specific locus test intravaginal
mouse 		0.5 ppb EMMUEG 39,69,2002


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
implant
rat 		lowest published toxic dose: 10 gm/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Immunological Including Allergic: Increase in cellular immune response 		BJSUAM 52,49,1965
implant
rat 		toxic dose : 3,768 mg/kg Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Tumorigenic: Tumors at site of application 		EXPEAM 19,424,1963
subcutaneous
rat 		lowest published toxic dose: 2,500 mg/kg Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Skin and Appendages: Tumors 		AMPLAO 67,589,1959


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 2,000 mg/kg N/R FCTOD7 41,405,2003
oral
mouse 		lethal dose (50 percent kill): 14,700 mg/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		GISAAA 51(10),75,1986
oral
mouse 		lethal dose (50 percent kill): >4,000 mg/kg N/R FCTOD7 41,405,2003
oral
rat 		lethal dose (50 percent kill): >20 gm/kg Behavioral: Altered sleep time (including change in righting reflex)

Behavioral: Somnolence (general depressed activity)

Behavioral: Muscle weakness 		GISAAA 51(10),75,1986
rectal
mouse 		lethal dose (50 percent kill): >1,000 mg/kg N/R FCTOD7 41,405,2003


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
rat 		lowest published toxic concentration: 45 mg/m3/2 hour/15 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Blood: Changes in erythrocyte (RBC) count

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		TPKVAL 5,136,1963
oral
rat 		lowest published toxic dose: 22,500 mg/kg/45 day- intermittent Blood: Changes in serum composition (e.g. TP, bilirubin, cholesterol)

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		GISAAA 51(10),75,1986
oral
rat 		lowest published toxic dose: 315 gm/kg/90 day- continuous Gastrointestinal: Hypermotility, diarrhea FCTOD7 41,719,2003
oral
rat 		lowest published toxic dose: 315 gm/kg/90 day- continuous Liver: Changes in liver weight FCTOD7 41,719,2003
oral
rat 		lowest published toxic dose: 70 gm/kg/5 week- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain FCTOD7 41,729,2003


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 19,341,1979
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 19,341,1979
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMSUDL 7,56,1987
TOXICOLOGY REVIEW
AJMEAZ 38,409,1965


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 81944;
Number of Industries 159;
Total Number of Facilities 17,615;
Number of Occupations 98;
Total Number of Employees Exposed 124,708
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X8571;
Number of Industries 181;
Total Number of Facilities 25,435;
Number of Occupations 133;
Total Number of Employees Exposed 500,947;
Total Number of Female Employees Exposed 183,064


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as a textile warp sizing and finishing agent, and a component of adhesives
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NCI Carcinogenesis Studies (intravaginal);no evidence:mouse


REFERENCES:

CODEN
REFERENCE
AJMEAZ American Journal of Medicine. (Technical Pub., 875 Third Ave., New York, NY 10022) V.1- 1946-
AMPLAO AMA Archives of Pathology. (Chicago, IL) V.50(4)-69, 1950-60. For publisher information, see APLMAS.
BJSUAM British Journal of Surgery. (Quadrant Subscription Services Ltd., Oakfield House, Perrymount Rd., Haywards Heath, W. Sussex RH16 3DH, UK) V.1- 1913-
EMMUEG Environmental and Molecular Mutagenesis. (Alan R. Liss, Inc., 41 E. 11th St., New York, NY 10003) V.10- 1987-
EXPEAM Experientia. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1945-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979-
TPKVAL Toksikologiya Novykh Promyshlennykh Khimicheskikh Veshchestv. Toxicology of New Industrial Chemical Substances. For English translation, see TNICS*. (Izdatel'stvo Meditsina, Moscow, USSR) No.1- 1961-

Used as a textile warp sizing and finishing agent, and a component of adhesives

FDA-over the counter drug

RTECS Compound Description:
   Tumorigen

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