The Registry of Toxic Effects of Chemical Substances

Potassium nitrite (1:1)

RTECS #: TT3750000

CAS #: 7758-09-0

UPDATE: January 1997 MW: 85.11 MF: NO2•K


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. Nitrous acid, potassium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA inhibition other microorganisms 20 mmol/L JMOBAK 5,442,1962
mutation in microorganisms other microorganisms 500 mmol/L (-enzymatic activation step) JMOBAK 9,352,1964
mutation in microorganisms other microorganisms 500 mmol/L (-enzymatic activation step) JOVIAM 7,673,1971
mutation in microorganisms other microorganisms 20 mmol/L (-enzymatic activation step) JMOBAK 5,442,1962
mutation in microorganisms Salmonella typhimurium 3,300 µg/plate (+/-enzymatic activation step) MUREAV 260,321,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
guinea pig 		lowest published toxic dose: 137 gm/kg (18 week prior to copulation) Reproductive: Effects on newborn: Stillbirth TXAPA9 12,179,1968
oral
guinea pig 		lowest published toxic dose: 201 gm/kg (19 week prior to copulation) Reproductive: Effects on fertility: Abortion

Reproductive: Other effects to embryo or fetus 		TXAPA9 12,179,1968
oral
rat 		lowest published toxic dose: 30 gm/kg (60 day male/60 day prior to copulation) Reproductive: Effects on fertility: Female fertility index (e.g., # females pregnant per # sperm positive females; # females pregnant per # females mated) DABSAQ 28,3815,1968


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 85 gm/m3/2 hour Behavioral: Sleep

Behavioral: Excitement

Behavioral: Muscle contraction or spasticity 		GISAAA 48(1),62,1983
oral
human 		lowest published toxic dose: 1,428 µg/kg Ear: Tinnitus

Cardiac: Pulse rate increased without fall in BP

Vascular: BP lowering not characterized in autonomic section 		GISAAA 48(1),62,1983
oral
rabbit 		lethal dose (50 percent kill): 200 mg/kg N/R SOVEA7 27,246,1974


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 18 gm/kg/13 week- continuous Blood: Pigmented or nucleated red blood cells

Blood: Methemoglobinemia- Carboxhemoglobinemia

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		FCTOD7 26,851,1988


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83413;
Number of Industries 11;
Total Number of Facilities 205;
Number of Occupations 7;
Total Number of Employees Exposed 1,353
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83413;
Number of Industries 22;
Total Number of Facilities 788;
Number of Occupations 34;
Total Number of Employees Exposed 27,303;
Total Number of Female Employees Exposed 2,845


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
DABSAQ Dissertation Abstracts B: The Sciences and Engineering. (Ann Arbor, MI) V.27-29, 1966-69. For publisher information, see DABBBA.
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
JMOBAK Journal of Molecular Biology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
JOVIAM Journal of Virology. (American Soc. for Microbiology, 1913 I St., NW, Washington, DC 20006) V.1- 1967-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
SOVEA7 Southwestern Veterinarian. (College of Veterinary Medicine, Texas A & M Univ., College Station, TX 77843) V.1- 1948-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-

Used in analytical chemistry, as a vasodilator and as antidote for cyanide poisoning

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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