The Registry of Toxic Effects of Chemical Substances

Potassium pyrosulfite

RTECS #: TT4920000

CAS #: 16731-55-8

UPDATE: June 1999 MW: 222.32 MF: O5S2•K2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. REVIEWS:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Potassium metabisulfite
  2. Potassium disulfite
  3. Dipotassium disulfite
  1. Dipotassium metabisulfite
  2. Disulfurous acid, dipotassium salt (9CI)
  3. Pyrosulfurous acid, dipotassium salt


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
unscheduled DNA synthesis oral
rat 		400 mg/kg JJCREP 80,424,1989


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 35 gm/kg (49 day prior to copulation/1-21 day pregnant) Reproductive: Effects on newborn: Growth statistics (e.g., reduced weight gain) CRSBAW 172,470,1978


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Human Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 54,131,1992
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 54,131,1992


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 82177;
Number of Industries 17;
Total Number of Facilities 1,935;
Number of Occupations 13;
Total Number of Employees Exposed 5,348
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 82177;
Number of Industries 34;
Total Number of Facilities 4,265;
Number of Occupations 45;
Total Number of Employees Exposed 33,335;
Total Number of Female Employees Exposed 10,193


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: In vitro SCE-nonhuman
EPA TSCA Section 8(b) CHEMICAL INVENTORY


REFERENCES:

CODEN
REFERENCE
CRSBAW Comptes Rendus des Seances de la Societe de Biologie et de Ses Filiales. (SPPIF, B.P.22, F-41353 Vineuil, France) V.1- 1849-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985-

Used as an industrial chemical, food and feed additive, flavor, packaging material

NIOSH PROFILE (PHOTOGRAPHIC PROCESSING), FIRL, 4/78

RTECS Compound Description:
   Tumorigen
   Mutagen
   Reproductive Effector

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