The Registry of Toxic Effects of Chemical Substances

Propane, 1,3 - bis (2,3 - epoxypropoxy) - 2,2 - dimethyl -

RTECS #: TX3760000

CAS #: 17557-23-2

UPDATE: October 1997 MW: 216.31 MF: C11H20O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. NIOSH DOCUMENTATION AND SURVEILLANCE:
  6. STATUS IN FEDERAL AGENCIES:
  7. REFERENCES:

SYNONYMS:

  1. Diglycidyl ether of neopentyl gylcol
  2. 2,2' - ( (2,2 - Dimethyl - 1,3 - propanediyl) bis (oxymethylene) ) bisoxirane
  3. Oxirane, 2,2' - ( (2,2 - dimethyl - 1,3 - propanediyl) bis (oxymethylene) ) bis - (9CI)
  1. 1,3 - Bis (2,3 - epoxypropoxy) - 2,2 - dimethylpropane
  2. Heloxy WC68
  3. Neopentyl glycol diglycidyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
mutation in microorganisms Salmonella typhimurium 1 mg/plate (+/-enzymatic activation step) MUREAV 172,105,1986


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 9,393 mg/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		NTIS** ORNL-5762
skin
mouse 		toxic dose : 11 gm/kg/3 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		NTIS** ORNL-5762
skin
mouse 		toxic dose : 17 gm/kg/2 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		NTIS** ORNL-5762
skin
mouse 		toxic dose : 25 gm/kg/3 year- intermittent Tumorigenic: Equivocal tumorigenic agent by RTECS criteria

Skin and Appendages: Tumors 		NTIS** ORNL-5762


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lethal dose (50 percent kill): 4,500 mg/kg N/R 38MKAJ 2A,2212,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: X1484;
Number of Industries 6;
Total Number of Facilities 77;
Number of Occupations 7;
Total Number of Employees Exposed 2,838;
Total Number of Female Employees Exposed 44


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.

RTECS Compound Description:
   Tumorigen
   Mutagen

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