The Registry of Toxic Effects of Chemical Substances

Propane, 2,2 - bis (p - (2,3 - epoxypropoxy) phenyl) -

RTECS #: TX3800000

CAS #: 1675-54-3

UPDATE: November 2004 MW: 340.45 MF: C21H24O4


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. TUMORIGENIC DATA:
  5. ACUTE TOXICITY DATA:
  6. OTHER MULTIPLE DOSE DATA:
  7. REVIEWS:
  8. STANDARDS AND REGULATIONS:
  9. NIOSH DOCUMENTATION AND SURVEILLANCE:
  10. STATUS IN FEDERAL AGENCIES:
  11. REFERENCES:

SYNONYMS:

  1. 2,2' - ( (1 - Methylethylidene) bis (4,1 - phenyleneoxymethylene) ) bisoxirane
  2. 2,2 - Bis (4 - (2,3 - epoxypropyloxy) phenyl) propane
  3. 2,2 - Bis (4 - hydroxyphenyl) propane, diglycidyl ether
  4. 2,2 - Bis (p - glycidyloxyphenyl) propane
  5. 2,2 - Bis (p - hydroxyphenyl) propane, diglycidyl ether
  6. 4,4' - Dihydroxydiphenyldimethylmethane diglycidyl ether
  7. 4,4' - Isopropylidenediphenol diglycidyl ether
  8. BADGE
  9. Bis (4 - glycidyloxyphenyl) dimethyamethane
  10. Bis (4 - hydroxyphenyl) dimethylmethane diglycidyl ether
  11. Bisphenol A diglycidyl ether
  12. Bpdge
  13. D.E.R. 332
  14. Dian diglycidyl ether
  15. Dian - bis - glycidylether (Czech)
  1. Diglycidyl bisphenol A ether
  2. Diglycidyl ether of 2,2 - bis (4 - hydroxyphenyl) propane
  3. Diglycidyl ether of 2,2 - bis (p - hydroxyphenyl) propane
  4. Diglycidyl ether of 4,4' - isopropylidenediphenol
  5. Diglycidyl ether of bisphenol A
  6. Diomethane diglycidyl ether
  7. ERL - 2774
  8. Epi - Rez 508
  9. Epi - Rez 510
  10. Epotuf 37 - 140
  11. Epoxide A
  12. GY 6010
  13. Oligomer 340
  14. p,p' - Dihydroxydiphenyldimethylmethane diglycidyl ether


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		2 mg/24 hour severe 85JCAE -,782,1986
skin
rabbit 		500 mg open irritation test mild UCDS** 4/21/1967


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct skin
mouse 		20 gm/L CRNGDP 13,969,1992
mutation in microorganisms Salmonella typhimurium 33 µg/plate (+enzymatic activation step) MUREAV 172,105,1986
mutation in microorganisms Salmonella typhimurium 50 µg/plate/72 hour (-enzymatic activation step) MUTAEX 16,303,2001
mutation in microorganisms Salmonella typhimurium 100 µg/plate/72 hour (+enzymatic activation step) MUTAEX 16,303,2001
mutation in microorganisms Salmonella typhimurium 0.1 mg/plate (-enzymatic activation step) MUREAV 536,39,2003
micronucleus test human lymphocyte 12.5 mg/L/3 hour (-enzymatic activation step) MUREAV 536,39,2003


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 166 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Endocrine: Thyroid tumors 		FCTOD7 26,611,1988
skin
mouse 		toxic dose : 312 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Liver: Tumors

Reproductive: Tumorigenic effects: Ovarian tumors 		CNREA8 39,1718,1979
skin
mouse 		toxic dose : 312 gm/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors 		NTIS** ORNL-5375


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lethal dose (50 percent kill): 4 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		38MKAJ 2A,2219,1981
intraperitoneal
rat 		lethal dose (50 percent kill): 2,200 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		38MKAJ 2A,2219,1981
oral
mouse 		lethal dose (50 percent kill): 15,600 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		38MKAJ 2A,2219,1981
oral
rat 		lethal dose (50 percent kill): 11,300 µL/kg N/R UCDS** 4/21/1967
oral
rabbit 		lethal dose (50 percent kill): 1,980 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		38MKAJ 2A,2219,1981
skin
rabbit 		lethal dose (50 percent kill): 20 gm/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		38MKAJ 2A,2219,1981


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 4,100 mg/kg/13 week- intermittent Skin: After systemic exposure: Dermatitis, other NTIS** OTS0558858
skin
rat 		lowest published toxic dose: 52 gm/kg/2 year- intermittent Liver: Other changes

Skin: After systemic exposure: Dermatitis, other 		NTIS** OTS0559600
skin
rat 		lowest published toxic dose: 68 gm/kg/13 week- intermittent Behavioral: Food intake (animal)

Skin: After systemic exposure: Dermatitis, other

Nutritional and Gross Metabolic: Weight loss or decreased weight gain 		NTIS** OTS0558862


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 47,237,1989
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1285,1999
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1285,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 47,237,1989


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 5 mg/m3 (respirable dust), 2003
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 10 mg/m3 (total dust), 2003


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: T0018;
Number of Industries 8;
Total Number of Facilities 163;
Number of Occupations 10;
Total Number of Employees Exposed 1,413
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83440;
Number of Industries 54;
Total Number of Facilities 2,505;
Number of Occupations 54;
Total Number of Employees Exposed 32,393
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83440;
Number of Industries 28;
Total Number of Facilities 1,109;
Number of Occupations 38;
Total Number of Employees Exposed 25,257;
Total Number of Female Employees Exposed 4,341


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: Histidine reversion-Ames test
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978


REFERENCES:

CODEN
REFERENCE
38MKAJ "Patty's Industrial Hygiene and Toxicology," 3rd rev. ed., Clayton, G.D., and F.E. Clayton, eds., New York, John Wiley & Sons, Inc., 1978-82. Vol. 3 originally pub. in 1979; pub. as 2nd rev. ed. in 1985.
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941-
CRNGDP Carcinogenesis (London). (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1980-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
MUTAEX Mutagenesis. (Oxford Univ. Press, Pinkhill House, Southfield Road, Eynsham, Oxford OX8 1JJ, UK) V.1- 1986-
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

RTECS Compound Description:
   Tumorigen
   Mutagen
   Human Data
   Primary Irritant

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