The Registry of Toxic Effects of Chemical Substances

Propane, 1 - butoxy - 2,3 - epoxy -

RTECS #: TX4200000

CAS #: 2426-08-6

UPDATE: November 2004 MW: 130.21 MF: C7H14O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. MUTATION DATA:
  4. REPRODUCTIVE EFFECTS DATA:
  5. ACUTE TOXICITY DATA:
  6. REVIEWS:
  7. STANDARDS AND REGULATIONS:
  8. NIOSH DOCUMENTATION AND SURVEILLANCE:
  9. STATUS IN FEDERAL AGENCIES:
  10. REFERENCES:

SYNONYMS:

  1. 2,3 - Epoxypropyl butyl ether
  2. Ageflex BGE
  3. BGE (OSHA)
  4. Butyl glycidyl ether
  5. Ether, butyl 2,3 - epoxypropyl
  6. Ether, butyl glycidyl
  1. Glycidyl butyl ether
  2. Oxirane, (butoxymethyl) - (9CI)
  3. TK 10408
  4. n - Butyl glycidyl ether
  5. n - Butyl glycidyl ether (ACGIH:OSHA)


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		91 mg mild AMIHAB 14,250,1956
eye
rabbit 		750 µg/24 hour severe 85JCAE -,774,1986
skin
rabbit 		454 mg/3 day mild AMIHAB 14,250,1956
skin
rabbit 		20 mg/24 hour moderate 85JCAE -,774,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage Escherichia coli 1 µmol/L ARTODN 46,277,1980
mutation in microorganisms Escherichia coli 20 µmol/L (-enzymatic activation step) ARTODN 46,277,1980
mutation in microorganisms Salmonella typhimurium 10 mg/plate (+/-enzymatic activation step) MUREAV 66,367,1979
micronucleus test intraperitoneal
mouse 		675 mg/kg ENMUDM 2,521,1980
other mutation test systems Escherichia coli 1 mmol/L MUREAV 231,205,1990
sister chromatid exchange hamster lung 2,500 µmol/L MUREAV 249,55,1991


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 36 gm/kg (24 day male) Reproductive: Effects on embryo or fetus: Fetal death MUREAV 124,225,1983


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
mouse 		lethal concentration (50 percent kill): 260 mg/m3 Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression 		GISAAA 51(8),91,1986
inhalation
rat 		lethal concentration (50 percent kill): 1,030 ppm/8 hour Eye: Lacrimation

Gastrointestinal: Changes in structure or function of salivary glands

Lung, Thorax, or Respiration: Dyspnea 		AMIHAB 14,250,1956
intraperitoneal
mouse 		lethal dose (50 percent kill): 700 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
intraperitoneal
rat 		lethal dose (50 percent kill): 1,140 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
mouse 		lethal dose (50 percent kill): 1,530 mg/kg Brain and Coverings: Recordings from specific areas of CNS

Behavioral: Somnolence (general depressed activity)

Behavioral: Ataxia 		AMIHAB 14,250,1956
oral
rat 		lethal dose (50 percent kill): 1,660 mg/kg Behavioral: Somnolence (general depressed activity)

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Respiratory depression 		GISAAA 51(8),91,1986
skin
rat 		lethal dose (50 percent kill): >2,150 mg/kg N/R TSCAT* OTS0515483
skin
rabbit 		lethal dose (50 percent kill): 2,520 µL/kg N/R AIHAAP 23,95,1962


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 25 ppm DTLVS* TLV/BEI,2003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 50 ppm (270 mg/m3) DTLVS* 3,33,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 50 ppm (270 mg/m3) CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - AUSTRALIA time-weighted average 25 ppm (135 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRIA Suspected Carcinogen, JAN1999
Occupational Exposure Limit - BELGIUM time-weighted average 25 ppm (133 mg/m3), JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 6 ppm (30 mg/m3), JAN1999
Occupational Exposure Limit - FINLAND short term exposure limit 25 ppm (135 mg/m3), Skin, JAN1999
Occupational Exposure Limit - FRANCE VME 25 ppm (135 mg/m3), JAN1999
Occupational Exposure Limit - GERMANY Skin, Carcinogen, JAN1999
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 135 mg/m3, 2003
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Exposure Limit - SWEDEN NGV 10 ppm (50 mg/m3), TKV 15 ppm (80 mg/m3), JAN1999
Occupational Exposure Limit - SWITZERLAND MAK- week 25 ppm (135 mg/m3), KZG- week 50 ppm (270 mg/m3), Skin, JAN1999
Occupational Exposure Limit - TURKEY time-weighted average 50 ppm (270 mg/m3), JAN1993
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 25 ppm (135 mg/m3), SEP2000
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN, KOREA American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 25 ppm
Occupational Exposure Limit IN NEW ZEALAND, SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 25 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO BUTYL GLYCIDYL ETHER-air ceiling concentration 5.6 ppm/15 minute NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 14720;
Number of Industries 37;
Total Number of Facilities 1,596;
Number of Occupations 45;
Total Number of Employees Exposed 19,839
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 14720;
Number of Industries 56;
Total Number of Facilities 2,593;
Number of Occupations 57;
Total Number of Employees Exposed 60,217;
Total Number of Female Employees Exposed 14,929


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA 8(a) PRELIMINARY ASSESSMENT INFORMATION, FINAL RULE FEREAC 47,26992,82
Used as reactive diluent for epoxy resins, flooring, laminating, and electrical
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA Section 8(e) Risk Notification, 8EHQ-0293-8718;8EHQ-0892-9000
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001
NIOSH CURRENT INTELLIGENCE BULLETIN 29, 1978
NIOSH Analytical Method, 1994: n-Butyl glycidyl ether, 1616


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
AIHAAP American Industrial Hygiene Association Journal. (AIHA, 475 Wolf Ledges Pkwy., Akron, OH 44311) V.19- 1958-
AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU.
ARTODN Archives of Toxicology. (Springer-Verlag, Heidelberger Pl. 3, D-1000 Berlin 33, Fed. Rep. Ger.) V.32- 1974-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936-
GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460)

Used as reactive diluent for epoxy resins, flooring, laminating, and electrical

NIOSH PROFILE (EPOXY COMPOUNDS), SRC, 2/82

NIOSH PROFILE (ETHERS, GLYCIDYL), SRC, 10/77

RTECS Compound Description:
   Mutagen
   Reproductive Effector
   Primary Irritant

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