The Registry of Toxic Effects of Chemical Substances

Propanedial

RTECS #: TX6475000

CAS #: 542-78-9

UPDATE: February 2005 MW: 72.07 MF: C3H4O2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. TUMORIGENIC DATA:
  4. ACUTE TOXICITY DATA:
  5. OTHER MULTIPLE DOSE DATA:
  6. REVIEWS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Malonaldehyde
  2. Malondialdehyde
  3. Malonic aldehyde
  4. Malonic dialdehyde
  5. Malonodialdehyde
  1. Malonyldialdehyde
  2. NCI - C54842
  3. 1,3 - Propanedial
  4. 1,3 - Propanedialdehyde
  5. 1,3 - Propanedione


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA adduct Escherichia coli 20 mmol/L MUREAV 88,23,1981
DNA adduct mammal (species unspecified) lymphocyte 250 mg/L/5 hour EJBCAI 5,178,1968
DNA adduct intraperitoneal
mouse 		3,000 nmol/L/1 week- intermittent CALEDQ 185,13,2002
DNA damage human leukocyte 1 mmol/L CLREAS 23(5),595A,1975
DNA damage human fibroblast 10 µmol/L CLREAS 23(5),595A,1975
DNA inhibition human fibroblast 25 mg/L EJBCAI 5,178,1968
DNA inhibition rat fibroblast 1 mmol/L JTEHD6 6,811,1980
DNA repair Escherichia coli 20 mmol/L MUREAV 88,23,1981
mutation in microorganisms Escherichia coli 2 mmol/L (-enzymatic activation step) MUREAV 88,23,1981
mutation in microorganisms Salmonella typhimurium 13,850 nmol/plate (+enzymatic activation step) BTERDG 2,81,1980
mutation in microorganisms Salmonella typhimurium 1 nmol/plate (-enzymatic activation step) MUREAV 78,113,1980
mutation in mammalian somatic cells mouse lymphocyte 10 µmol/L MAGDA3 11,137,1979
morphological transform rat fibroblast 1 mmol/L JTEHD6 6,811,1980
other mutation test systems rat fibroblast 100 µmol/L JTEHD6 6,811,1980


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
skin
mouse 		lowest published toxic dose: 7,488 mg/kg/2 year- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Lung, Thorax, or Respiration: Tumors

Blood: Lymphoma including Hodgkin's disease 		AUODDK 55,3,1980
skin
mouse 		toxic dose : 30 gm/kg/9 week- intermittent Tumorigenic: Carcinogenic by RTECS criteria

Skin and Appendages: Tumors

Tumorigenic: Tumors at site of application 		JNCIAM 53,1771,1974


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lethal dose (50 percent kill): 606 mg/kg N/R AUODDK 55,3,1980
oral
rat 		lethal dose (50 percent kill): 632 mg/kg Behavioral: Muscle weakness

Lung, Thorax, or Respiration: Dyspnea

Lung, Thorax, or Respiration: Cyanosis 		TXAPA9 7,826,1965


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
mouse 		lowest published toxic dose: 45,000 mg/kg/90 day- continuous Nutritional and Gross Metabolic: Weight loss or decreased weight gain VCVGK* -,403,1994
oral
mouse 		lowest published toxic dose: 22,500 mg/kg/90 day- continuous Gastrointestinal: Other changes

Liver: Other changes

Kidney, Ureter, and Bladder: Inflammation, necrosis or scarring of bladder 		VCVGK* -,403,1994
oral
rat 		lowest published toxic dose: 36.5 mg/kg/1 year- continuous Liver: Tumors

Related to Chronic Data: Death in the "MULTIPLE DOSE" data type field 		VCVGK* -,403,1994


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
International Agency for Research on Cancer (IARC) Cancer Review Animal Limited Evidence IMEMDT 71,1037,1999
International Agency for Research on Cancer (IARC) Cancer Review Animal Inadequate Evidence IMEMDT 36,163,1985
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 36,163,1985
International Agency for Research on Cancer (IARC) Cancer Review Human No Adequate Data IMEMDT 71,1037,1999
International Agency for Research on Cancer (IARC) Cancer Review Group 3 IMEMDT 71,1037,1999
TOXICOLOGY REVIEW
TOLED5 134,51,2002
TOXICOLOGY REVIEW
MUREAV 5441152003


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO MALONALDEHYDE-air Carcinogen lowest feasible concentration NIOSH* DHHS #92-100,1992


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Inconclusive: Histidine reversion-Ames test
Used as a food and feed additive, flavor and packaging material
NIOSH CURRENT INTELLIGENCE BULLETIN #55, September 1991


REFERENCES:

CODEN
REFERENCE
AUODDK Acta Universitatis Ouluensis, Series D: Medica. (Oulu Univ. Library, Box 186, SF-90101 Oulu 10, Finland) No.1- 1972-
BTERDG Biological Trace Element Research. (Humana Press Inc., POB 2148, Clifton, NJ 07015) V.1- 1979-
CALEDQ Cancer Letters (Shannon, Ireland). (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1975-
CLREAS Clinical Research. (Slack Inc., 6900 Grove Rd., Thorofare, NJ 08086) V.6- 1958-
EJBCAI European Journal of Biochemistry. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1967-
IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972-
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8.
JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76-
MAGDA3 Mechanisms of Ageing and Development. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) V.1- 1972-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
TOLED5 Toxicology Letters. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1977-
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959-
VCVGK* "Vrednie chemichescie veshestva, galogen I kislorod sodergashie organicheskie soedinenia". (Hazardous substances. Galogen and oxygen containing substances), Bandman A.L. et al., Chimia, 1994.

Used as a food and feed additive, flavor and packaging material

RTECS Compound Description:
   Tumorigen
   Mutagen

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