The Registry of Toxic Effects of Chemical Substances

Propane, 1,3 - dichloro -

RTECS #: TX9660000

CAS #: 142-28-9

UPDATE: December 1997 MW: 112.99 MF: C3H6Cl2


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. ACUTE TOXICITY DATA:
  4. OTHER MULTIPLE DOSE DATA:
  5. STATUS IN FEDERAL AGENCIES:
  6. REFERENCES:

SYNONYMS:

  1. 1,3 - Dichloropropane
  2. R 270fa
  1. Trimethylene dichloride


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA damage human lymphocyte 500 µmol/L MUREAV 371,185,1996
mutation in microorganisms Salmonella typhimurium 10 µmol/plate (+/-enzymatic activation step) ENMUDM 2,59,1980
micronucleus test human lymphocyte 500 µmol/L MUREAV 371,185,1996
sister chromatid exchange hamster lung 6,600 µmol/L ENMUDM 9,401,1987


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
dog 		lowest published lethal dose: 3 gm/kg Lung, Thorax, or Respiration: Chronic pulmonary edema or congestion

Liver: Other changes

Blood: Hemorrhage 		AJHYA2 16,325,1932
unreported route
mouse 		lethal dose (50 percent kill): 3,600 mg/kg Gastrointestinal: Ulceration or bleeding from stomach

Gastrointestinal: Ulceration or bleeding from small intestine 		ESKGA2 28,P31,1982


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
oral
rat 		lowest published toxic dose: 8,400 mg/kg/14 day- intermittent Liver: Changes in liver weight

Kidney, Ureter, and Bladder: Changes in bladder weight

Biochemical: Metabolism (intermediary): Other proteins 		JACTDZ 10(4),421,1991
oral
rat 		lowest published toxic dose: 72 gm/kg/90 day- intermittent Liver: Changes in liver weight

Nutritional and Gross Metabolic: Weight loss or decreased weight gain

Biochemical: Enzyme inhibition, induction, or change in blood or tissue levels: Phosphatases 		JACTDZ 10(4),421,1991


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
N/R N/R N/R


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
AJHYA2 American Journal of Hygiene. (Baltimore, MD) V.1-80, 1921-64. For publisher information, see AJEPAS.
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG.
ESKGA2 Eisei Kagaku. Hygienic Chemistry. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1953-
JACTDZ Journal of the American College of Toxicology. (Mary Ann Liebert, Inc., 1651 Third Ave., New York, NY 10128) V.1-12, 1982-1993. Discontinued.
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-

RTECS Compound Description:
   Mutagen

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