The Registry of Toxic Effects of Chemical Substances

2 - Propanol, 1 - amino -

RTECS #: UA5775000

CAS #: 78-96-6

UPDATE: July 2000 MW: 75.13 MF: C3H9NO


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. SKIN AND EYE IRRITATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. STANDARDS AND REGULATIONS:
  6. NIOSH DOCUMENTATION AND SURVEILLANCE:
  7. STATUS IN FEDERAL AGENCIES:
  8. REFERENCES:

SYNONYMS:

  1. alpha - Aminoisopropyl alcohol
  2. 1 - Aminopropan - 2 - ol
  3. 1 - Amino - 2 - propanol
  4. 2 - Hydroxypropylamine
  5. 2 - Hydroxy - 1 - propylamine
  1. Isopropanolamine
  2. 1 - Methyl - 2 - aminoethanol
  3. Mono - iso - propanolamine
  4. Threamine


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
eye
rabbit 		970 µg severe UCDS** 5/21/1971
eye
rabbit 		250 µg/24 hour severe 85JCAE -,683,1986
skin
rabbit 		485 mg open irritation test moderate UCDS** 5/21/1971
skin
rabbit 		500 mg/24 hour mild 85JCAE -,683,1986


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
N/R N/R N/R N/R


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
unreported route
rat 		lowest published toxic dose: 280 µg/kg (1 day male) Reproductive: Effects on fertility: Pre- implantation mortality (e.g., reduction in number of implants per female; total number of implants per corpora lutea) TLSMA6 140,79,1981


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intraperitoneal
mouse 		lowest published lethal dose: 250 mg/kg Behavioral: Excitement CBCCT* 4,232,1952
oral
rat 		lethal dose (50 percent kill): 1,715 mg/kg Behavioral: Somnolence (general depressed activity)

Gastrointestinal: Hypermotility, diarrhea

Nutritional and Gross Metabolic: Body temperature decrease 		GTPZAB 30(7),46,1986
skin
mammal (species unspecified) 		lethal dose (50 percent kill): >1 gm/kg N/R GTPZAB 30(7),46,1986
skin
rabbit 		lethal dose (50 percent kill): 1,640 µL/kg N/R UCDS** 5/21/1971


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
N/R N/R N/R


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Occupational Exposure Limit - RUSSIA short term exposure limit 1 mg/m3, Skin, JAN1993


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 83332;
Number of Industries 60;
Total Number of Facilities 3,204;
Number of Occupations 59;
Total Number of Employees Exposed 51,002
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 83332;
Number of Industries 79;
Total Number of Facilities 6,922;
Number of Occupations 80;
Total Number of Employees Exposed 132,873;
Total Number of Female Employees Exposed 13,538


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA TSCA Section 8(b) CHEMICAL INVENTORY
EPA TSCA Section 8(d) unpublished health/safety studies
EPA TSCA TEST SUBMISSION (TSCATS) DATA BASE, JANUARY 2001


REFERENCES:

CODEN
REFERENCE
85JCAE "Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418)
GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI
TLSMA6 Trudy Leningradskogo Sanitarno-Gigienicheskogo Meditsinskogo Instituta. (Leningrad, Russia) V.1-145, 1949-82. Discontinued.
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817)

NIOSH PROFILE (ALKANOLAMINES), SRC, 5/81

RTECS Compound Description:
   Reproductive Effector
   Primary Irritant

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